Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaH   Type   Regulator
Locus tag   EL092_RS05375 Genome accession   NZ_LR134291
Coordinates   1116551..1117951 (+) Length   466 a.a.
NCBI ID   WP_012000485.1    Uniprot ID   A8AX52
Organism   Streptococcus gordonii strain NCTC7868     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 1111551..1122951
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  EL092_RS05355 (NCTC7868_01067) - 1111947..1114490 (+) 2544 WP_012000481.1 M1 family metallopeptidase -
  EL092_RS05360 (NCTC7868_01068) - 1114547..1115089 (-) 543 WP_012000482.1 biotin transporter BioY -
  EL092_RS05365 (NCTC7868_01069) - 1115301..1115756 (+) 456 WP_012000483.1 hypothetical protein -
  EL092_RS05370 (NCTC7868_01070) ciaR 1115887..1116561 (+) 675 WP_048774883.1 response regulator transcription factor Regulator
  EL092_RS05375 (NCTC7868_01071) ciaH 1116551..1117951 (+) 1401 WP_012000485.1 sensor histidine kinase Regulator
  EL092_RS05380 (NCTC7868_01072) - 1117953..1118879 (+) 927 WP_012000486.1 ketopantoate reductase family protein -
  EL092_RS05385 (NCTC7868_01073) - 1118903..1120354 (-) 1452 WP_012000487.1 alpha-amylase -
  EL092_RS05390 (NCTC7868_01074) rpsT 1120581..1120829 (-) 249 WP_008808726.1 30S ribosomal protein S20 -
  EL092_RS05395 (NCTC7868_01075) coaA 1120926..1121846 (-) 921 WP_012000489.1 type I pantothenate kinase -
  EL092_RS05400 (NCTC7868_01076) - 1121951..1122544 (+) 594 WP_012000490.1 class I SAM-dependent methyltransferase -

Sequence

Protein


Download         Length: 466 a.a.        Molecular weight: 52969.99 Da        Isoelectric Point: 9.4441

>NTDB_id=1120360 EL092_RS05375 WP_012000485.1 1116551..1117951(+) (ciaH) [Streptococcus gordonii strain NCTC7868]
MLNKLRRTLYADDFSYFIRYFGVFTLIFSAMTLLIIQIMRSGLYTTVDDNLKSLSQNPRSVLHLALARAANMQPTIDEGQ
PSDDESGPQNAPDPGPMDNLKVNSNTEAVLFDEGLKPLTTADHFLSLKTISIKKKDVGKIIQINLKNNYGQEELYRMLVF
EINPSEFLSGNLLNKVKYAAVLINVNQLEQTSQNHEQIIVIVMISFWLISIIASIYLARVSVKPLIDSMQKQKSFVENAS
HELRTPLAVLQNRLETLFRKPEATIMESSENIASSLEEVRNMRMLTTNLLNLARRDDGIKPEIADVEPEFFTTTFANYEI
IADENEKAFVYENHINHNIKTDRTLLKQLMTILFDNAVKYTEEDGVIKFIVWSKDRSLYLRVSDNGPGINNEDKKKIFDR
FYRVDKARTRQKGGFGLGLSLAKQIADALKGTITVKDNRPKGTIFEVKISIKSESKKKSTKLIGNK

Nucleotide


Download         Length: 1401 bp        

>NTDB_id=1120360 EL092_RS05375 WP_012000485.1 1116551..1117951(+) (ciaH) [Streptococcus gordonii strain NCTC7868]
ATGCTGAATAAACTTAGACGAACTTTATATGCGGATGATTTTTCATATTTCATTCGCTATTTTGGTGTATTCACACTTAT
TTTCTCGGCTATGACTCTTTTAATCATTCAAATTATGCGCTCAGGGCTCTATACAACCGTTGACGATAATTTAAAAAGTT
TAAGTCAGAATCCCAGATCTGTTCTCCACCTTGCTTTGGCTCGTGCAGCCAATATGCAACCGACGATTGATGAAGGCCAG
CCATCCGATGATGAATCTGGACCACAAAACGCACCAGATCCTGGACCAATGGATAATCTGAAGGTGAATTCGAACACTGA
AGCAGTCTTGTTTGATGAAGGATTGAAACCATTGACTACTGCAGATCATTTTCTTAGTTTAAAAACGATTTCAATCAAGA
AAAAGGATGTTGGTAAAATTATTCAGATTAATTTGAAAAACAACTATGGACAAGAAGAACTCTATCGTATGTTGGTTTTT
GAAATTAATCCAAGTGAATTCTTATCTGGGAATCTTTTGAACAAAGTAAAATATGCAGCTGTTCTGATTAATGTCAATCA
ATTGGAGCAAACCAGTCAGAATCATGAACAAATCATTGTCATTGTTATGATTAGCTTCTGGTTAATCTCAATCATTGCCA
GTATCTATTTGGCTCGGGTCAGTGTGAAGCCTCTAATAGACAGTATGCAGAAGCAAAAATCCTTTGTTGAAAACGCCAGC
CATGAGTTGCGTACTCCTTTAGCTGTTTTGCAAAACCGTTTGGAAACTCTTTTCCGAAAACCGGAAGCTACTATTATGGA
ATCTAGCGAAAATATTGCCTCCAGCCTGGAAGAAGTTCGGAATATGCGGATGCTAACAACTAATCTATTGAATCTAGCAA
GAAGAGATGATGGCATTAAGCCTGAAATTGCTGATGTTGAACCAGAATTTTTCACTACAACATTTGCCAACTATGAAATC
ATTGCTGATGAAAACGAGAAAGCATTTGTCTACGAAAATCATATTAACCACAATATCAAGACAGACAGAACACTTTTAAA
ACAGCTAATGACCATTCTATTTGATAATGCTGTAAAATATACGGAAGAAGATGGGGTTATTAAGTTTATAGTATGGTCAA
AAGACCGTTCTCTTTACTTACGAGTGTCCGATAACGGTCCTGGAATCAATAATGAAGATAAGAAGAAAATATTTGATCGC
TTTTATCGGGTTGATAAGGCCAGAACAAGACAAAAGGGTGGTTTTGGCTTAGGCCTATCTCTTGCAAAACAAATAGCCGA
TGCTCTAAAGGGGACAATTACTGTTAAAGATAATAGACCGAAAGGTACCATTTTTGAAGTCAAAATTTCCATTAAATCAG
AAAGCAAGAAAAAATCAACTAAGCTAATAGGAAATAAATGA

Domains

Predicted by InterproScan.

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c)

(342-449)

His Kinase A (phospho-acceptor) domain (HisKA)

(233-298)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A8AX52

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaH Streptococcus pneumoniae Rx1

65.939

98.283

0.648
  ciaH Streptococcus pneumoniae D39

65.939

98.283

0.648
  ciaH Streptococcus pneumoniae R6

65.939

98.283

0.648
  ciaH Streptococcus pneumoniae TIGR4

65.939

98.283

0.648
  ciaH Streptococcus mutans UA159

54.343

96.352

0.524

Multiple sequence alignment