Detailed information    

insolico Bioinformatically predicted

Overview

Name   comEA/celA/cilE   Type   Machinery gene
Locus tag   EL087_RS04080 Genome accession   NZ_LR134288
Coordinates   825491..826195 (+) Length   234 a.a.
NCBI ID   WP_126406982.1    Uniprot ID   A0A4U9YWJ0
Organism   Streptococcus milleri strain NCTC11169     
Function   dsDNA binding to the cell surface (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 820491..831195
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  EL087_RS04055 (NCTC11169_00806) - 820844..822049 (+) 1206 WP_185952264.1 multidrug efflux MFS transporter -
  EL087_RS04060 rpmG 822033..822182 (+) 150 WP_003024746.1 50S ribosomal protein L33 -
  EL087_RS04065 (NCTC11169_00807) secG 822222..822455 (+) 234 WP_003024744.1 preprotein translocase subunit SecG -
  EL087_RS04070 (NCTC11169_00808) rnr 822547..824880 (+) 2334 WP_126406980.1 ribonuclease R -
  EL087_RS04075 (NCTC11169_00809) smpB 824843..825310 (+) 468 WP_022526922.1 SsrA-binding protein SmpB -
  EL087_RS04080 (NCTC11169_00810) comEA/celA/cilE 825491..826195 (+) 705 WP_126406982.1 helix-hairpin-helix domain-containing protein Machinery gene
  EL087_RS04085 (NCTC11169_00811) comEC/celB 826179..828407 (+) 2229 WP_126406984.1 DNA internalization-related competence protein ComEC/Rec2 Machinery gene
  EL087_RS04090 (NCTC11169_00812) - 828488..829174 (+) 687 WP_232008265.1 DUF805 domain-containing protein -
  EL087_RS04095 (NCTC11169_00814) - 829708..830694 (+) 987 WP_126406988.1 Gfo/Idh/MocA family protein -

Sequence

Protein


Download         Length: 234 a.a.        Molecular weight: 25099.08 Da        Isoelectric Point: 5.0127

>NTDB_id=1120262 EL087_RS04080 WP_126406982.1 825491..826195(+) (comEA/celA/cilE) [Streptococcus milleri strain NCTC11169]
MLETIIEKMKEYKILIGLSLIGLIIAGFFMINGQSSRQSNVAELAQETVTSSEAESKEISTRTKKNSQKEKAETQTSSSE
ESEFLTVDVKGAVKNPGIYQLKKTSRINDAIQKAGGLTTDADSKSINLAQKLTDEAVVYVATMGENAASVSSNTGQSSTS
GTSEVASQKGNKVNLNTADLSELQTISGIGQKRAQDILDYREANGKFNSVDDLKNVSGVGAKTLEKLKEYVTVD

Nucleotide


Download         Length: 705 bp        

>NTDB_id=1120262 EL087_RS04080 WP_126406982.1 825491..826195(+) (comEA/celA/cilE) [Streptococcus milleri strain NCTC11169]
ATGTTAGAGACAATCATTGAAAAGATGAAAGAGTATAAAATTTTGATTGGTTTAAGTTTGATTGGTTTGATAATAGCAGG
ATTTTTTATGATAAATGGTCAATCTAGTAGACAATCAAATGTAGCAGAGCTCGCACAGGAAACAGTTACGAGTTCGGAGG
CAGAATCAAAAGAAATTTCAACTAGAACGAAGAAAAACTCACAGAAAGAAAAAGCAGAGACTCAAACGAGTTCAAGTGAA
GAATCAGAATTTTTAACCGTAGATGTCAAGGGTGCAGTCAAAAATCCAGGTATTTATCAACTGAAAAAGACTAGCCGTAT
CAATGATGCGATTCAAAAAGCAGGTGGTTTAACGACAGACGCTGACAGCAAGTCTATCAATTTGGCGCAGAAACTAACGG
ATGAAGCTGTTGTTTATGTGGCAACTATGGGTGAGAATGCGGCGAGTGTTTCAAGCAATACAGGACAATCTTCAACATCA
GGAACTAGTGAAGTCGCATCGCAAAAAGGGAATAAGGTCAATCTAAATACAGCTGATTTATCTGAGTTGCAGACCATTTC
TGGTATTGGTCAAAAACGCGCGCAAGATATTTTAGATTATCGGGAGGCAAACGGGAAATTTAATTCCGTTGATGACCTGA
AAAATGTATCAGGAGTAGGTGCTAAAACACTAGAGAAATTGAAAGAATATGTCACAGTGGATTAA

Domains

Predicted by InterproScan.

SLBB domain (SLBB)

(87-140)

Helix-hairpin-helix motif (HHH_3)

(169-232)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A4U9YWJ0

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comEA/celA/cilE Streptococcus pneumoniae TIGR4

53.219

99.573

0.53
  comEA/celA/cilE Streptococcus pneumoniae Rx1

53.219

99.573

0.53
  comEA/celA/cilE Streptococcus pneumoniae D39

53.219

99.573

0.53
  comEA/celA/cilE Streptococcus pneumoniae R6

53.219

99.573

0.53
  comEA/celA/cilE Streptococcus mitis NCTC 12261

52.361

99.573

0.521
  comEA/celA/cilE Streptococcus mitis SK321

52.361

99.573

0.521
  comEA Streptococcus thermophilus LMD-9

44.255

100

0.444
  comEA Lactococcus lactis subsp. cremoris KW2

42.06

99.573

0.419

Multiple sequence alignment