Detailed information
Bioinformatically predicted
Overview
| Name | prx | Type | Regulator |
| Locus tag | EL070_RS05320 | Genome accession | NZ_LR134284 |
| Coordinates | 1018705..1018887 (-) | Length | 60 a.a. |
| NCBI ID | WP_011017399.1 | Uniprot ID | - |
| Organism | Streptococcus pyogenes strain NCTC8232 | ||
| Function | Inhibit ComR activation (predicted from homology) Competence regulation |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| Prophage | 1014999..1058691 | 1018705..1018887 | within | 0 |
Gene organization within MGE regions
Location: 1014999..1058691
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| EL070_RS05300 (NCTC8232_01061) | - | 1014999..1015730 (-) | 732 | WP_232013145.1 | LPXTG cell wall anchor domain-containing protein | - |
| EL070_RS05305 (NCTC8232_01062) | lepA | 1016054..1017886 (-) | 1833 | WP_010922253.1 | translation elongation factor 4 | - |
| EL070_RS10025 | - | 1018010..1018416 (-) | 407 | Protein_967 | nucleoside-diphosphate kinase | - |
| EL070_RS05320 (NCTC8232_01065) | prx | 1018705..1018887 (-) | 183 | WP_011017399.1 | hypothetical protein | Regulator |
| EL070_RS05325 (NCTC8232_01066) | speA | 1019108..1019863 (+) | 756 | WP_009880239.1 | streptococcal pyrogenic exotoxin SpeA | - |
| EL070_RS05330 (NCTC8232_01067) | - | 1019985..1021202 (-) | 1218 | WP_023611377.1 | peptidoglycan amidohydrolase family protein | - |
| EL070_RS05335 (NCTC8232_01069) | - | 1021321..1021548 (-) | 228 | WP_003058873.1 | phage holin | - |
| EL070_RS05340 (NCTC8232_01070) | - | 1021545..1021817 (-) | 273 | WP_011017397.1 | hypothetical protein | - |
| EL070_RS05345 (NCTC8232_01071) | - | 1021829..1022461 (-) | 633 | WP_023611372.1 | hypothetical protein | - |
| EL070_RS05350 (NCTC8232_01072) | - | 1022464..1022892 (-) | 429 | WP_002988448.1 | DUF1617 family protein | - |
| EL070_RS05355 (NCTC8232_01073) | - | 1022904..1024808 (-) | 1905 | WP_011017395.1 | gp58-like family protein | - |
| EL070_RS05360 (NCTC8232_01074) | - | 1024818..1025825 (-) | 1008 | WP_011017394.1 | hyaluronoglucosaminidase | - |
| EL070_RS05365 (NCTC8232_01075) | - | 1025822..1027873 (-) | 2052 | WP_038432431.1 | phage tail spike protein | - |
| EL070_RS05370 (NCTC8232_01076) | - | 1027870..1028640 (-) | 771 | WP_011017392.1 | distal tail protein Dit | - |
| EL070_RS05375 (NCTC8232_01077) | - | 1028653..1032753 (-) | 4101 | WP_023611657.1 | phage tail tape measure protein | - |
| EL070_RS05385 (NCTC8232_01078) | gpG | 1032979..1033281 (-) | 303 | WP_011017390.1 | phage tail assembly chaperone G | - |
| EL070_RS05390 (NCTC8232_01079) | - | 1033374..1033958 (-) | 585 | WP_011017389.1 | major tail protein | - |
| EL070_RS05395 (NCTC8232_01080) | - | 1033970..1034350 (-) | 381 | WP_011017388.1 | hypothetical protein | - |
| EL070_RS05400 (NCTC8232_01081) | - | 1034343..1034741 (-) | 399 | WP_011017387.1 | HK97 gp10 family phage protein | - |
| EL070_RS05405 (NCTC8232_01082) | - | 1034743..1035105 (-) | 363 | WP_011017386.1 | hypothetical protein | - |
| EL070_RS05410 (NCTC8232_01083) | - | 1035098..1035406 (-) | 309 | WP_011017385.1 | hypothetical protein | - |
| EL070_RS10030 (NCTC8232_01084) | - | 1035406..1035579 (-) | 174 | WP_011017384.1 | hypothetical protein | - |
| EL070_RS05415 (NCTC8232_01085) | - | 1035593..1036726 (-) | 1134 | WP_011017383.1 | phage major capsid protein | - |
| EL070_RS05420 (NCTC8232_01086) | - | 1036743..1037549 (-) | 807 | WP_023611660.1 | head maturation protease, ClpP-related | - |
| EL070_RS05425 (NCTC8232_01087) | - | 1037530..1038717 (-) | 1188 | WP_011017381.1 | phage portal protein | - |
| EL070_RS05430 (NCTC8232_01088) | - | 1038870..1039082 (-) | 213 | WP_136260634.1 | hypothetical protein | - |
| EL070_RS05435 (NCTC8232_01089) | - | 1039085..1040815 (-) | 1731 | WP_011017380.1 | terminase large subunit domain-containing protein | - |
| EL070_RS05440 (NCTC8232_01090) | - | 1040828..1041145 (-) | 318 | WP_011017379.1 | P27 family phage terminase small subunit | - |
| EL070_RS05445 (NCTC8232_01091) | - | 1041286..1041591 (-) | 306 | WP_011017378.1 | HNH endonuclease | - |
| EL070_RS05450 (NCTC8232_01092) | - | 1041584..1041970 (-) | 387 | WP_011017377.1 | hypothetical protein | - |
| EL070_RS05455 (NCTC8232_01093) | - | 1041996..1042199 (-) | 204 | WP_011017376.1 | hypothetical protein | - |
| EL070_RS05460 (NCTC8232_01094) | - | 1042257..1042550 (-) | 294 | WP_011017375.1 | hypothetical protein | - |
| EL070_RS05465 (NCTC8232_01095) | - | 1042704..1043279 (-) | 576 | WP_011054435.1 | site-specific integrase | - |
| EL070_RS05470 (NCTC8232_01096) | - | 1043439..1043840 (-) | 402 | WP_011017373.1 | hypothetical protein | - |
| EL070_RS05475 (NCTC8232_01097) | - | 1043855..1044682 (-) | 828 | WP_011017372.1 | prohibitin family protein | - |
| EL070_RS05480 (NCTC8232_01098) | - | 1044685..1045023 (-) | 339 | WP_011017371.1 | helix-turn-helix domain-containing protein | - |
| EL070_RS05485 (NCTC8232_01099) | - | 1045020..1045301 (-) | 282 | WP_011054431.1 | hypothetical protein | - |
| EL070_RS05490 (NCTC8232_01100) | ssbA | 1045316..1045708 (-) | 393 | WP_011017370.1 | single-stranded DNA-binding protein | Machinery gene |
| EL070_RS05495 (NCTC8232_01101) | - | 1045705..1045926 (-) | 222 | WP_011017369.1 | hypothetical protein | - |
| EL070_RS05500 (NCTC8232_01102) | - | 1045923..1046408 (-) | 486 | WP_011017368.1 | DUF1642 domain-containing protein | - |
| EL070_RS05505 (NCTC8232_01103) | - | 1046413..1047045 (-) | 633 | WP_023611652.1 | N-6 DNA methylase | - |
| EL070_RS05510 (NCTC8232_01104) | - | 1047047..1047316 (-) | 270 | WP_011017366.1 | hypothetical protein | - |
| EL070_RS10035 (NCTC8232_01105) | - | 1047313..1047483 (-) | 171 | WP_023611649.1 | hypothetical protein | - |
| EL070_RS05515 (NCTC8232_01106) | - | 1047480..1047923 (-) | 444 | WP_011017365.1 | YopX family protein | - |
| EL070_RS10340 (NCTC8232_01107) | - | 1047940..1048065 (-) | 126 | WP_257000584.1 | hypothetical protein | - |
| EL070_RS05520 (NCTC8232_01108) | - | 1048079..1048306 (-) | 228 | WP_032467212.1 | hypothetical protein | - |
| EL070_RS05525 (NCTC8232_01109) | - | 1048306..1049118 (-) | 813 | WP_023611651.1 | ATP-binding protein | - |
| EL070_RS05530 (NCTC8232_01110) | - | 1049118..1049879 (-) | 762 | WP_011017361.1 | conserved phage C-terminal domain-containing protein | - |
| EL070_RS05535 (NCTC8232_01111) | dnaB | 1049872..1051212 (-) | 1341 | WP_011017360.1 | replicative DNA helicase | - |
| EL070_RS05540 (NCTC8232_01112) | - | 1051199..1051387 (-) | 189 | WP_032461348.1 | hypothetical protein | - |
| EL070_RS05545 (NCTC8232_01113) | - | 1051508..1051699 (-) | 192 | WP_011017359.1 | hypothetical protein | - |
| EL070_RS05550 (NCTC8232_01114) | - | 1051792..1052049 (-) | 258 | WP_011054421.1 | hypothetical protein | - |
| EL070_RS05555 (NCTC8232_01115) | - | 1052123..1052842 (-) | 720 | WP_011017357.1 | ORF6C domain-containing protein | - |
| EL070_RS05560 (NCTC8232_01116) | - | 1052894..1053394 (+) | 501 | WP_032464978.1 | hypothetical protein | - |
| EL070_RS10345 (NCTC8232_01117) | - | 1053514..1053648 (-) | 135 | WP_011017356.1 | hypothetical protein | - |
| EL070_RS05565 (NCTC8232_01118) | - | 1053722..1053934 (-) | 213 | WP_011054420.1 | helix-turn-helix domain-containing protein | - |
| EL070_RS05570 (NCTC8232_01119) | - | 1053969..1054244 (-) | 276 | WP_011017354.1 | hypothetical protein | - |
| EL070_RS05575 (NCTC8232_01120) | - | 1054533..1054883 (+) | 351 | WP_011017353.1 | helix-turn-helix domain-containing protein | - |
| EL070_RS05580 (NCTC8232_01121) | - | 1054887..1055279 (+) | 393 | WP_011017352.1 | ImmA/IrrE family metallo-endopeptidase | - |
| EL070_RS05585 (NCTC8232_01122) | - | 1055290..1056030 (+) | 741 | WP_011017351.1 | type II toxin-antitoxin system PemK/MazF family toxin | - |
| EL070_RS05590 (NCTC8232_01123) | - | 1056341..1057537 (+) | 1197 | WP_011017350.1 | tyrosine-type recombinase/integrase | - |
| EL070_RS05595 (NCTC8232_01128) | - | 1058059..1058691 (-) | 633 | WP_014635437.1 | TIGR01906 family membrane protein | - |
Sequence
Protein
Download Length: 60 a.a. Molecular weight: 6989.07 Da Isoelectric Point: 4.3094
>NTDB_id=1120111 EL070_RS05320 WP_011017399.1 1018705..1018887(-) (prx) [Streptococcus pyogenes strain NCTC8232]
MLYIDEFKEAIDKGYILGDTVAIVRKNGKIFDYVLPGEGVRPWEVLTEEKVEEVMRELDK
MLYIDEFKEAIDKGYILGDTVAIVRKNGKIFDYVLPGEGVRPWEVLTEEKVEEVMRELDK
Nucleotide
Download Length: 183 bp
>NTDB_id=1120111 EL070_RS05320 WP_011017399.1 1018705..1018887(-) (prx) [Streptococcus pyogenes strain NCTC8232]
ATGTTATATATAGATGAGTTTAAAGAAGCGATTGATAAGGGGTATATTTTAGGTGACACAGTAGCGATAGTGCGTAAAAA
CGGAAAGATATTTGATTATGTGTTACCAGGAGAGGGAGTCAGGCCATGGGAGGTGTTGACAGAGGAAAAAGTGGAAGAAG
TGATGAGGGAATTAGACAAATAA
ATGTTATATATAGATGAGTTTAAAGAAGCGATTGATAAGGGGTATATTTTAGGTGACACAGTAGCGATAGTGCGTAAAAA
CGGAAAGATATTTGATTATGTGTTACCAGGAGAGGGAGTCAGGCCATGGGAGGTGTTGACAGAGGAAAAAGTGGAAGAAG
TGATGAGGGAATTAGACAAATAA
Domains
No domain identified.
3D structure
| Source | ID | Structure |
|---|
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| prx | Streptococcus pyogenes MGAS315 |
78.333 |
100 |
0.783 |
| prx | Streptococcus pyogenes MGAS315 |
75 |
100 |
0.75 |
| prx | Streptococcus pyogenes MGAS315 |
71.667 |
100 |
0.717 |
| prx | Streptococcus pyogenes MGAS8232 |
70 |
100 |
0.7 |
| prx | Streptococcus pyogenes MGAS315 |
95.122 |
68.333 |
0.65 |
| prx | Streptococcus pyogenes MGAS315 |
65 |
100 |
0.65 |
| prx | Streptococcus pyogenes MGAS315 |
75.61 |
68.333 |
0.517 |