Detailed information NTG1117850

Bioinformatically predicted

Overview

• Name: comE
• Type: Regulator
• Locus tag: ELZ47_RS11810
• Genome accession: NZ_LR134002
• Coordinates: 2354794..2355558 (-)
• Length: 254 a.a.
• NCBI ID: WP_002899424.1
• Uniprot ID: A0A0B7GUD9
• Organism: Streptococcus sanguinis strain NCTC 10904
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type	MGE coordinates	Gene coordinates	Relative position	Distance (bp)
IS/Tn	2353437..2354180	2354794..2355558	flank	614

Gene organization within MGE regions

Location: 2353437..2355558

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ELZ47_RS11795 (NCTC10904_02323)	-	2353437..2354484 (-)	1048	Protein_2233	IS3 family transposase	-
ELZ47_RS11810 (NCTC10904_02327)	comE	2354794..2355558 (-)	765	WP_002899424.1	competence system response regulator transcription factor ComE	Regulator

Sequence

Protein

• Length: 254 a.a.
• Molecular weight: 29851.13 Da
• Isoelectric Point: 8.0162

>NTDB_id=1117850 ELZ47_RS11810 WP_002899424.1 2354794..2355558(-) (comE) [Streptococcus sanguinis strain NCTC 10904]
MKVLVLEDTVSHQVRMETTLAEIAEELGIDIQVQVTGKIKEFKKYIENGDVNQLYFLDIDIKGEETKGLEVAQFIRHHNP
YAIIVFVTSKSEFATMTFKYKVSALDFIDKDINNDAFKNRIKDSILYTKSTLIENTNMVDYFEYSYRGNDVRMPYNDILY
IETTGSSHKLRIVGKNFLKEFYGTITDIQEKDQQSKRFFSPHKSYLVNIGNIVDYDKKNREIIFYENHRCPVTRLRVKYL
KDIFENKGKRVDKA

Nucleotide

• Length: 765 bp

>NTDB_id=1117850 ELZ47_RS11810 WP_002899424.1 2354794..2355558(-) (comE) [Streptococcus sanguinis strain NCTC 10904]
ATGAAAGTGTTAGTTTTAGAGGATACCGTATCTCATCAAGTCAGGATGGAAACGACATTAGCAGAAATTGCTGAGGAACT
TGGAATTGACATCCAGGTTCAGGTTACAGGAAAAATCAAAGAATTCAAAAAATATATTGAAAATGGAGACGTTAACCAGC
TTTATTTTTTGGATATTGACATTAAGGGGGAGGAAACAAAGGGGCTGGAAGTAGCTCAATTTATCCGTCATCATAATCCT
TATGCCATTATAGTTTTTGTAACCTCAAAATCTGAATTTGCTACTATGACTTTTAAATATAAAGTATCAGCACTTGATTT
TATTGATAAAGATATCAACAATGATGCTTTTAAAAATAGAATCAAAGACAGTATTCTTTACACTAAGAGTACACTAATTG
AAAATACCAATATGGTAGATTATTTTGAATATAGTTATCGTGGCAATGATGTTCGAATGCCTTATAACGATATTTTGTAT
ATCGAAACGACAGGGAGCTCTCATAAACTTCGGATTGTCGGTAAAAATTTTCTCAAGGAGTTTTATGGAACGATAACAGA
TATTCAAGAAAAAGATCAGCAATCTAAACGATTTTTTTCACCACATAAATCTTATCTGGTTAATATTGGCAACATTGTTG
ATTATGACAAGAAAAATCGAGAAATTATTTTTTACGAAAATCATCGCTGTCCGGTCACTCGTTTAAGAGTGAAATATCTG
AAAGATATTTTCGAAAATAAAGGGAAAAGAGTTGACAAAGCTTAA

Domains

Predicted by InterproScan.

• LytTr DNA-binding domain (LytTR) (152-244)

• Response regulator receiver domain (Response_reg) (4-121)

3D structure

• AlphaFold DB: A0A0B7GUD9

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE	Streptococcus infantis strain Atu-4	68.4	98.425	0.673
comE/comE2	Streptococcus gordonii strain NCTC7865	68.4	98.425	0.673
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	68.4	98.425	0.673
comE	Streptococcus mitis NCTC 12261	68	98.425	0.669
comE	Streptococcus mitis SK321	67.2	98.425	0.661
comE	Streptococcus pneumoniae Rx1	66.8	98.425	0.657
comE	Streptococcus pneumoniae D39	66.8	98.425	0.657
comE	Streptococcus pneumoniae R6	66.8	98.425	0.657
comE	Streptococcus pneumoniae TIGR4	66.8	98.425	0.657
comE/blpR	Streptococcus mutans UA159	38.8	98.425	0.382