Detailed information    

insolico Bioinformatically predicted

Overview

Name   htrA   Type   Regulator
Locus tag   FOA32_RS07435 Genome accession   NZ_JABTYC020000010
Coordinates   56294..57472 (+) Length   392 a.a.
NCBI ID   WP_037615063.1    Uniprot ID   A0A0A0DIF9
Organism   Streptococcus sinensis strain Forsyth1A     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 51294..62472
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  FOA32_RS07405 - 52031..52954 (+) 924 Protein_48 IS481 family transposase -
  FOA32_RS07410 (FOA32_001480) comE 53050..53796 (-) 747 Protein_49 competence system response regulator transcription factor ComE -
  FOA32_RS07415 (FOA32_001481) comD/comD1 53793..55139 (-) 1347 WP_217473256.1 ATP-binding protein Regulator
  FOA32_RS07420 (FOA32_001482) comC 55179..55313 (-) 135 WP_148881652.1 bacteriocin Regulator
  FOA32_RS07430 (FOA32_001483) rlmH 55611..56090 (-) 480 WP_037615060.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  FOA32_RS07435 (FOA32_001484) htrA 56294..57472 (+) 1179 WP_037615063.1 S1C family serine protease Regulator
  FOA32_RS07440 (FOA32_001485) spo0J 57536..58297 (+) 762 WP_217473257.1 ParB/RepB/Spo0J family partition protein Regulator
  FOA32_RS07445 (FOA32_001486) dnaA 58510..59865 (+) 1356 WP_037615069.1 chromosomal replication initiator protein DnaA -
  FOA32_RS07450 (FOA32_001487) dnaN 60023..61159 (+) 1137 WP_217473258.1 DNA polymerase III subunit beta -
  FOA32_RS07455 (FOA32_001488) - 61332..61526 (+) 195 WP_062201624.1 DUF951 domain-containing protein -

Sequence

Protein


Download         Length: 392 a.a.        Molecular weight: 41297.36 Da        Isoelectric Point: 4.7587

>NTDB_id=1112708 FOA32_RS07435 WP_037615063.1 56294..57472(+) (htrA) [Streptococcus sinensis strain Forsyth1A]
MKNASNFFKKFLLLFIVLVVGFIGGSLGNLATTFFTAKLASISSSNSKTTISTAYKNSTDTTKAVKKVQNAVVSVITYAD
SNKQEIINNESNDEPQVASEGSGVIYKKEGKYAYLVTNTHVLNGATNVDILLADGSKVPGEVVGSDVYSDISVVKISSEK
VTDVAEFGDSSSLTVGETAIAIGSPLGTEYANSVTQGIISSLGRNVTLQSEDGQNISTTALQTDAAINPGNSGGPLINIQ
GQVIGITSSKISNNGQTSVEGMGFAIPSNDVVNIINQLEQSGTVTRPALGIQMLDLANITTTDLAKLNLPSSVKSGVLVR
SVQEGMPAENKLQKYDIITKIDDKEVESTSDLQSALYKHAIGDEIKVTYYRDGKEATTTIKLTKSTQDLGGN

Nucleotide


Download         Length: 1179 bp        

>NTDB_id=1112708 FOA32_RS07435 WP_037615063.1 56294..57472(+) (htrA) [Streptococcus sinensis strain Forsyth1A]
ATGAAAAACGCTTCAAACTTCTTCAAAAAGTTTTTGTTGCTTTTTATTGTTTTAGTTGTGGGCTTTATTGGCGGAAGCCT
AGGAAATTTAGCTACTACATTTTTTACTGCTAAATTGGCTAGTATCAGCTCTTCTAATTCTAAAACCACAATATCAACTG
CTTATAAAAACTCAACTGACACCACAAAGGCCGTTAAAAAGGTCCAAAATGCAGTTGTATCGGTTATCACTTACGCAGAT
TCCAATAAACAAGAAATTATCAATAATGAATCAAATGATGAGCCTCAGGTAGCTAGTGAAGGATCCGGAGTGATTTATAA
GAAGGAAGGAAAATATGCCTACCTTGTTACTAATACTCATGTACTGAATGGTGCAACAAATGTTGATATACTTTTAGCAG
ATGGCAGCAAGGTTCCAGGAGAAGTTGTTGGTTCAGATGTTTATTCTGATATTTCTGTAGTAAAGATTAGCTCTGAAAAA
GTAACTGATGTAGCTGAATTCGGGGATTCTAGCTCCCTGACAGTAGGAGAAACTGCTATTGCCATCGGAAGCCCTCTTGG
AACAGAATATGCCAACTCTGTAACACAAGGAATCATTTCCAGTCTGGGTAGAAATGTGACACTTCAATCTGAAGACGGTC
AAAATATTTCAACAACTGCACTTCAAACAGATGCTGCTATCAACCCTGGTAACTCTGGTGGCCCACTCATCAACATTCAA
GGACAAGTAATTGGTATTACATCTAGTAAAATCTCAAACAATGGCCAAACCTCTGTAGAAGGTATGGGATTTGCGATTCC
ATCTAATGACGTTGTCAATATCATCAATCAATTGGAACAAAGTGGTACAGTTACACGCCCTGCTCTAGGAATCCAGATGC
TAGATTTAGCTAATATTACCACCACTGACTTAGCAAAATTGAATCTTCCTTCATCTGTAAAATCAGGTGTCCTTGTTCGC
TCTGTTCAAGAAGGTATGCCTGCTGAAAATAAGCTTCAGAAATACGATATCATCACAAAAATTGACGATAAAGAAGTTGA
ATCAACCAGTGATTTACAATCTGCACTCTACAAGCATGCTATCGGAGATGAGATAAAAGTTACTTACTATCGTGATGGTA
AAGAAGCAACAACAACCATTAAACTGACTAAATCAACTCAAGATTTGGGCGGCAATTAA

Domains

Predicted by InterproScan.

Trypsin-like peptidase domain (Trypsin_2)

(101-246)

Peptidase family M50 (Peptidase_M50)

(233-387)

PDZ domain (PDZ_2)

(287-382)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A0A0DIF9

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  htrA Streptococcus gordonii str. Challis substr. CH1

69.289

100

0.696
  htrA Streptococcus mitis NCTC 12261

65.729

99.745

0.656
  htrA Streptococcus pneumoniae Rx1

65.473

99.745

0.653
  htrA Streptococcus pneumoniae D39

65.473

99.745

0.653
  htrA Streptococcus pneumoniae R6

65.473

99.745

0.653
  htrA Streptococcus pneumoniae TIGR4

65.473

99.745

0.653
  htrA Streptococcus mutans UA159

56.642

100

0.577

Multiple sequence alignment