Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   HMPREF9319_RS04885 Genome accession   NZ_GL397128
Coordinates   1019899..1020573 (-) Length   224 a.a.
NCBI ID   WP_003064882.1    Uniprot ID   E0PDT5
Organism   Streptococcus equinus ATCC 700338     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 1014899..1025573
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  HMPREF9319_RS04860 (HMPREF9319_1003) deoC 1015380..1016042 (-) 663 WP_003064871.1 deoxyribose-phosphate aldolase -
  HMPREF9319_RS04865 (HMPREF9319_1004) - 1016498..1017091 (-) 594 WP_003064873.1 class I SAM-dependent methyltransferase -
  HMPREF9319_RS04870 (HMPREF9319_1005) coaA 1017207..1018127 (+) 921 WP_003064875.1 type I pantothenate kinase -
  HMPREF9319_RS04875 (HMPREF9319_1006) rpsT 1018202..1018453 (+) 252 WP_003064878.1 30S ribosomal protein S20 -
  HMPREF9319_RS04880 (HMPREF9319_1007) ciaH 1018569..1019909 (-) 1341 WP_003064880.1 sensor histidine kinase Regulator
  HMPREF9319_RS04885 (HMPREF9319_1008) ciaR 1019899..1020573 (-) 675 WP_003064882.1 response regulator transcription factor Regulator
  HMPREF9319_RS04890 (HMPREF9319_1009) - 1020766..1023309 (-) 2544 WP_003064884.1 M1 family metallopeptidase -
  HMPREF9319_RS04895 (HMPREF9319_1010) phoU 1023532..1024185 (-) 654 WP_003064885.1 phosphate signaling complex protein PhoU -
  HMPREF9319_RS04900 (HMPREF9319_1011) pstB 1024217..1024975 (-) 759 WP_003064887.1 phosphate ABC transporter ATP-binding protein PstB -

Sequence

Protein


Download         Length: 224 a.a.        Molecular weight: 25441.17 Da        Isoelectric Point: 4.3831

>NTDB_id=1111689 HMPREF9319_RS04885 WP_003064882.1 1019899..1020573(-) (ciaR) [Streptococcus equinus ATCC 700338]
MIKILLVEDDLSLSNSIFDFLDDFADVMQVFDGEEGLYEAESGVYDLILLDLMLPEKDGFQVLKELREKSVTTPVLIMTA
KESLDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRSGKFSDNNLSYGELTVTTSTNTTTINGKEVEMLGKEFDLLVY
FLQNQNVILPKSQIFDRIWGFDSDTTISVVEVYVSKIRKKLKGTTFAKNLQTLRSVGYILKNAE

Nucleotide


Download         Length: 675 bp        

>NTDB_id=1111689 HMPREF9319_RS04885 WP_003064882.1 1019899..1020573(-) (ciaR) [Streptococcus equinus ATCC 700338]
ATGATTAAAATATTATTAGTAGAAGACGATTTGAGTTTATCTAATTCCATTTTTGATTTTTTAGACGATTTTGCTGATGT
AATGCAAGTGTTTGATGGCGAGGAAGGTTTGTATGAAGCAGAGAGTGGTGTATATGACCTTATTCTACTTGACCTAATGT
TACCTGAGAAAGATGGCTTCCAGGTTCTAAAAGAATTACGAGAAAAGTCTGTAACAACACCTGTACTTATTATGACTGCG
AAAGAAAGCCTCGACGATAAAGGACATGGATTTGAGTTGGGAGCTGATGATTATTTAACTAAACCCTTTTACCTTGAGGA
ATTAAAAATGCGTATCCAAGCTCTTTTGAAACGTTCTGGTAAGTTTAGTGATAATAATTTGTCTTATGGAGAGCTAACTG
TTACTACTTCTACTAATACAACAACTATTAATGGTAAAGAAGTGGAAATGCTTGGTAAAGAATTTGACTTGTTGGTTTAT
TTCTTACAAAATCAAAATGTTATTTTACCAAAATCACAAATTTTTGATCGTATTTGGGGCTTTGATAGTGATACAACGAT
TTCGGTTGTTGAGGTTTACGTTTCAAAAATTCGAAAAAAACTTAAAGGCACTACTTTTGCTAAAAACCTTCAGACCCTAC
GGAGTGTAGGTTATATTCTGAAAAATGCTGAATAA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(4-112)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(145-220)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB E0PDT5

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus mutans UA159

92.825

99.554

0.924
  ciaR Streptococcus pneumoniae Rx1

86.607

100

0.866
  ciaR Streptococcus pneumoniae D39

86.607

100

0.866
  ciaR Streptococcus pneumoniae R6

86.607

100

0.866
  ciaR Streptococcus pneumoniae TIGR4

86.607

100

0.866
  covR Lactococcus lactis subsp. lactis strain DGCC12653

38.667

100

0.388
  vicR Streptococcus mutans UA159

35.47

100

0.371
  micA Streptococcus pneumoniae Cp1015

35.193

100

0.366

Multiple sequence alignment