Detailed information NTG0109012

Bioinformatically predicted

Overview

• Name: comE
• Type: Regulator
• Locus tag: ACAM23_RS11200
• Genome accession: NZ_AP031394
• Coordinates: 2139320..2140072 (-)
• Length: 250 a.a.
• NCBI ID: WP_000866065.1
• Uniprot ID: -
• Organism: Streptococcus pneumoniae strain 16P28
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2134320..2145072

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ACAM23_RS11175 (SPNE16P28_21520)	-	2134669..2137221 (+)	2553	WP_000834682.1	YfhO family protein	-
ACAM23_RS11180	-	2137251..2138428 (-)	1178	Protein_2165	YhgE/Pip family protein	-
ACAM23_RS11185 (SPNE16P28_21550)	-	2138535..2139077 (+)	543	WP_001158266.1	TetR/AcrR family transcriptional regulator	-
ACAM23_RS11200 (SPNE16P28_21560)	comE	2139320..2140072 (-)	753	WP_000866065.1	competence system response regulator transcription factor ComE	Regulator
ACAM23_RS11205 (SPNE16P28_21570)	comD/comD1	2140069..2141394 (-)	1326	WP_000362880.1	competence system sensor histidine kinase ComD	Regulator
ACAM23_RS11210 (SPNE16P28_21580)	comC/comC1	2141415..2141540 (-)	126	WP_000799689.1	competence-stimulating peptide ComC	Regulator
ACAM23_RS11220 (SPNE16P28_21590)	rlmH	2141822..2142301 (-)	480	WP_000695929.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
ACAM23_RS11225 (SPNE16P28_21600)	htrA	2142484..2143665 (+)	1182	WP_000681601.1	S1C family serine protease	Regulator
ACAM23_RS11230 (SPNE16P28_21610)	spo0J	2143723..2144481 (+)	759	WP_000410383.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 250 a.a.
• Molecular weight: 29958.31 Da
• Isoelectric Point: 6.5073

>NTDB_id=109012 ACAM23_RS11200 WP_000866065.1 2139320..2140072(-) (comE) [Streptococcus pneumoniae strain 16P28]
MKVLILEDVIEHQVRLERILDEISKESNIPISYKTTGKVREFEEYIENDEVNQLYFLDIDIHGIEKKGFEVAQLIRHYNP
YAIIVFITSRSEFATLTYKYQVSALDFVDKDINDEMFKKRIEQNIFYTKSMLLENEDVVDYFDYNYKGNDLKIPYHDILY
IETTGVSHKLRIIGKNFAKEFYGTMTDIQEKDKHTQRFYSPHKSFLVNIGNIREIDRKNLEIVFYEDHRCPISRLKIRKL
KDILEKKSQK

Nucleotide

• Length: 753 bp

>NTDB_id=109012 ACAM23_RS11200 WP_000866065.1 2139320..2140072(-) (comE) [Streptococcus pneumoniae strain 16P28]
ATGAAAGTTTTAATTTTAGAAGATGTTATTGAACATCAAGTGAGACTAGAGAGAATATTGGATGAAATTTCGAAAGAATC
GAATATTCCAATATCATACAAGACAACGGGAAAAGTCCGTGAATTTGAAGAATACATTGAAAATGATGAAGTAAATCAGC
TTTATTTCCTAGATATCGATATTCATGGAATTGAGAAAAAGGGATTTGAAGTGGCTCAGCTCATTCGTCATTACAATCCT
TACGCTATTATCGTCTTTATCACTAGTCGATCAGAGTTTGCGACTCTAACCTATAAATATCAGGTATCAGCCCTAGATTT
TGTTGATAAGGATATCAATGATGAGATGTTTAAGAAGAGAATTGAGCAAAATATCTTCTACACGAAGAGTATGTTACTTG
AAAATGAAGATGTTGTAGATTATTTCGACTACAATTACAAGGGAAATGATTTAAAAATTCCTTACCATGATATTTTGTAT
ATTGAAACAACAGGGGTATCTCATAAATTGCGCATTATTGGTAAGAATTTTGCAAAAGAGTTTTATGGTACCATGACAGA
TATTCAGGAAAAGGACAAACATACTCAGCGATTTTATTCTCCTCACAAGTCATTTTTGGTAAATATAGGCAATATCAGAG
AAATTGATCGAAAAAACTTAGAAATTGTTTTCTATGAAGACCATCGTTGTCCTATTTCAAGATTAAAAATTAGAAAATTA
AAAGATATTTTAGAGAAAAAATCTCAAAAGTGA

Domains

Predicted by InterproScan.

• LytTr DNA-binding domain (LytTR) (151-244)

• Response regulator receiver domain (Response_reg) (3-121)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE	Streptococcus pneumoniae Rx1	100	100	1
comE	Streptococcus pneumoniae D39	100	100	1
comE	Streptococcus pneumoniae R6	100	100	1
comE	Streptococcus pneumoniae TIGR4	100	100	1
comE	Streptococcus mitis SK321	99.2	100	0.992
comE	Streptococcus mitis NCTC 12261	98.4	100	0.984
comE	Streptococcus infantis strain Atu-4	91.2	100	0.912
comE/comE2	Streptococcus gordonii strain NCTC7865	62.8	100	0.628
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	62.8	100	0.628
comE/blpR	Streptococcus mutans UA159	41.296	98.8	0.408