Detailed information    

insolico Bioinformatically predicted

Overview

Name   covR   Type   Regulator
Locus tag   ACLFAM_RS02200 Genome accession   NZ_CP178226
Coordinates   458934..459626 (-) Length   230 a.a.
NCBI ID   WP_012898209.1    Uniprot ID   A0AAW7IPJ0
Organism   Lactococcus lactis strain L-WY410     
Function   repress the expression of comX (predicted from homology)   
Competence regulation

Genomic Context

Location: 453934..464626
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ACLFAM_RS02185 (ACLFAM_02185) - 455553..455894 (-) 342 WP_010906046.1 P-II family nitrogen regulator -
  ACLFAM_RS02190 (ACLFAM_02190) - 456026..457267 (-) 1242 WP_039115695.1 ammonium transporter -
  ACLFAM_RS02195 (ACLFAM_02195) covS 457450..458925 (-) 1476 WP_010906048.1 HAMP domain-containing histidine kinase Regulator
  ACLFAM_RS02200 (ACLFAM_02200) covR 458934..459626 (-) 693 WP_012898209.1 response regulator transcription factor Regulator
  ACLFAM_RS02205 (ACLFAM_02205) - 459782..460312 (-) 531 WP_012898210.1 YceD family protein -
  ACLFAM_RS02210 (ACLFAM_02210) - 460443..460688 (-) 246 WP_003130760.1 type B 50S ribosomal protein L31 -
  ACLFAM_RS02215 (ACLFAM_02215) - 460844..461308 (-) 465 WP_023188701.1 hypothetical protein -
  ACLFAM_RS02220 (ACLFAM_02220) - 461390..461752 (-) 363 WP_023188700.1 TIGR02328 family protein -
  ACLFAM_RS02225 (ACLFAM_02225) - 461978..462889 (-) 912 WP_023188699.1 CHAP domain-containing protein -
  ACLFAM_RS02230 (ACLFAM_02230) - 463002..463838 (-) 837 WP_039115700.1 metallophosphoesterase -

Sequence

Protein


Download         Length: 230 a.a.        Molecular weight: 26670.33 Da        Isoelectric Point: 5.1273

>NTDB_id=1088537 ACLFAM_RS02200 WP_012898209.1 458934..459626(-) (covR) [Lactococcus lactis strain L-WY410]
MTSKKILIIEDEKNLARFVSLELEHEGYATEIKDNGRSGLEEASSKDYDLILLDLMLPELDGFEVARRLRKEKDTPIIMM
TARDSTMDRVAGLDIGADDYITKPFAIEELLARVRAFFRREEHGHAVERAENTSFRDLVIDKTNRTVHRGKKVIDLTRRE
YDLLLTLMQNVGDVVTREHLVSQVWGYEEGTETNVVDVYIRYLRNKIDVEGQDSYIQTVRGLGYVMRERK

Nucleotide


Download         Length: 693 bp        

>NTDB_id=1088537 ACLFAM_RS02200 WP_012898209.1 458934..459626(-) (covR) [Lactococcus lactis strain L-WY410]
ATGACTTCAAAGAAAATTTTGATTATTGAGGATGAAAAGAATTTAGCGCGATTCGTCTCATTAGAATTAGAACATGAAGG
CTATGCGACTGAGATTAAAGATAATGGTCGTTCTGGTCTTGAAGAAGCAAGTTCAAAAGATTATGATTTAATCTTGCTTG
ATTTGATGCTTCCTGAACTTGACGGTTTTGAGGTAGCTCGTCGTTTACGAAAAGAAAAAGATACACCAATCATTATGATG
ACGGCACGTGATTCAACGATGGACCGTGTTGCTGGTCTTGATATTGGGGCTGATGATTATATCACTAAACCTTTTGCGAT
TGAGGAACTTTTGGCGCGTGTTCGTGCTTTCTTCCGTCGTGAAGAGCATGGTCATGCCGTTGAACGTGCTGAAAATACTT
CTTTCCGTGATCTTGTGATTGACAAAACGAATCGCACCGTTCATCGTGGTAAAAAAGTAATTGATTTAACACGTCGTGAG
TATGACCTCCTTTTGACATTGATGCAAAATGTTGGCGATGTTGTGACTCGTGAACATTTAGTTTCACAAGTTTGGGGATA
TGAAGAAGGAACAGAAACAAATGTTGTGGATGTTTATATTCGTTATCTTAGAAATAAAATTGATGTTGAAGGTCAAGATA
GCTATATTCAAACTGTTCGTGGCTTAGGTTATGTAATGCGTGAACGCAAATAA

Domains

Predicted by InterproScan.

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(153-226)

Response regulator receiver domain (Response_reg)

(6-115)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  covR Lactococcus lactis subsp. lactis strain DGCC12653

99.565

100

0.996
  covR Streptococcus salivarius strain HSISS4

68.421

99.13

0.678
  vicR Streptococcus mutans UA159

45.887

100

0.461
  micA Streptococcus pneumoniae Cp1015

43.478

100

0.435
  ciaR Streptococcus mutans UA159

37.611

98.261

0.37
  ciaR Streptococcus pneumoniae Rx1

36.726

98.261

0.361
  ciaR Streptococcus pneumoniae D39

36.726

98.261

0.361
  ciaR Streptococcus pneumoniae R6

36.726

98.261

0.361
  ciaR Streptococcus pneumoniae TIGR4

36.726

98.261

0.361

Multiple sequence alignment