Detailed information    

insolico Bioinformatically predicted

Overview

Name   covS   Type   Regulator
Locus tag   ACLFAM_RS02195 Genome accession   NZ_CP178226
Coordinates   457450..458925 (-) Length   491 a.a.
NCBI ID   WP_010906048.1    Uniprot ID   A0A2A9ICZ0
Organism   Lactococcus lactis strain L-WY410     
Function   repress the expression of comX (predicted from homology)   
Competence regulation

Genomic Context

Location: 452450..463925
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ACLFAM_RS02180 (ACLFAM_02180) murD 453709..455061 (-) 1353 WP_039115692.1 UDP-N-acetylmuramoyl-L-alanine--D-glutamate ligase -
  ACLFAM_RS02185 (ACLFAM_02185) - 455553..455894 (-) 342 WP_010906046.1 P-II family nitrogen regulator -
  ACLFAM_RS02190 (ACLFAM_02190) - 456026..457267 (-) 1242 WP_039115695.1 ammonium transporter -
  ACLFAM_RS02195 (ACLFAM_02195) covS 457450..458925 (-) 1476 WP_010906048.1 HAMP domain-containing histidine kinase Regulator
  ACLFAM_RS02200 (ACLFAM_02200) covR 458934..459626 (-) 693 WP_012898209.1 response regulator transcription factor Regulator
  ACLFAM_RS02205 (ACLFAM_02205) - 459782..460312 (-) 531 WP_012898210.1 YceD family protein -
  ACLFAM_RS02210 (ACLFAM_02210) - 460443..460688 (-) 246 WP_003130760.1 type B 50S ribosomal protein L31 -
  ACLFAM_RS02215 (ACLFAM_02215) - 460844..461308 (-) 465 WP_023188701.1 hypothetical protein -
  ACLFAM_RS02220 (ACLFAM_02220) - 461390..461752 (-) 363 WP_023188700.1 TIGR02328 family protein -
  ACLFAM_RS02225 (ACLFAM_02225) - 461978..462889 (-) 912 WP_023188699.1 CHAP domain-containing protein -
  ACLFAM_RS02230 (ACLFAM_02230) - 463002..463838 (-) 837 WP_039115700.1 metallophosphoesterase -

Sequence

Protein


Download         Length: 491 a.a.        Molecular weight: 56195.08 Da        Isoelectric Point: 4.8253

>NTDB_id=1088536 ACLFAM_RS02195 WP_010906048.1 457450..458925(-) (covS) [Lactococcus lactis strain L-WY410]
MKKLFTFNKKKETVEESSAKRSIMLRWAFANTVFCFITFTLFATLTYQLTISSFIKEEQQLLTRSMDSVEEVLEKADAPL
NSSNLNTYIEATSKIQNGESEGMSLGSIIGTRKAFYIYDLNHKLLYSTNRHTFGFQNQANNEMKEIRGENPGYLVQRKII
SKSTGQVVGYLQAFYDTTTYHRISNLLLIVLLILEIVALIVAQLIGYFMANYFMKPLEKLYQGMQEMANDPTNDFEPIEI
QSGDEIEELAHVYNDMMLKMKAYLEQQNRFVSDVSHELRTPLAVLDGHINLLNRWGKNDPEVLDESLQASLDEVDRMKKM
LEEMLALARLENVDLSSEELDCDVGKVCNRALKNFQLLHDDFEIVLDNRLIYPTHARISENHFEQGLRILLDNAAKYSPD
DRKEIVITVSEDEQFVITSVSDKGIGISEEDINHLFERFFRADKARNREIGGTGLGLSILARLAENYQGEIEVNSELGLG
STFTLKFPKIK

Nucleotide


Download         Length: 1476 bp        

>NTDB_id=1088536 ACLFAM_RS02195 WP_010906048.1 457450..458925(-) (covS) [Lactococcus lactis strain L-WY410]
ATGAAAAAATTATTTACTTTCAATAAGAAAAAAGAGACGGTAGAGGAAAGTTCGGCTAAGCGGTCTATCATGCTTAGGTG
GGCTTTTGCTAACACCGTTTTTTGTTTTATTACTTTTACTTTGTTTGCTACTTTGACTTATCAATTGACAATCAGTTCTT
TTATTAAAGAAGAACAACAATTATTAACTCGCTCTATGGATAGTGTTGAGGAAGTCTTAGAAAAAGCAGATGCTCCTTTG
AATTCATCGAATTTGAACACATATATTGAAGCGACATCAAAGATTCAAAATGGTGAGTCTGAAGGAATGAGTTTGGGTAG
TATCATTGGGACACGGAAAGCATTTTATATTTATGACTTAAATCATAAATTATTGTATTCAACGAATCGACATACTTTTG
GTTTTCAGAATCAGGCTAATAATGAAATGAAAGAGATTCGGGGAGAAAATCCAGGTTATTTAGTTCAGAGAAAAATTATT
TCTAAGTCAACAGGACAAGTTGTGGGATACTTACAGGCTTTTTATGATACGACGACTTATCATCGAATTTCTAATCTTCT
TTTGATTGTCTTGTTAATTTTAGAAATTGTTGCCTTGATTGTCGCTCAGTTGATTGGTTATTTCATGGCTAATTACTTTA
TGAAACCATTGGAAAAACTTTATCAGGGCATGCAAGAAATGGCAAATGATCCAACAAATGATTTTGAACCGATTGAAATT
CAAAGTGGAGATGAAATCGAAGAGTTGGCTCATGTTTACAATGATATGATGTTGAAGATGAAGGCATATCTTGAACAGCA
AAATCGCTTTGTTTCTGATGTTTCTCATGAATTAAGAACACCTTTAGCTGTCTTGGATGGACATATTAACTTGTTGAATC
GATGGGGGAAAAATGATCCAGAAGTATTAGATGAATCTTTGCAGGCAAGTTTAGATGAAGTTGATCGAATGAAGAAAATG
CTTGAGGAGATGTTGGCTCTTGCTCGTCTTGAAAATGTTGACTTATCAAGTGAAGAACTGGATTGTGATGTTGGAAAAGT
TTGTAATCGGGCCCTTAAGAATTTTCAGCTTTTGCATGATGATTTTGAAATAGTGCTTGATAACCGGCTTATTTATCCCA
CTCATGCGCGAATTTCAGAAAATCATTTTGAACAAGGTTTACGAATTCTGTTAGATAATGCTGCTAAATACTCTCCTGAT
GATCGTAAAGAAATCGTGATTACTGTTTCTGAGGATGAACAGTTTGTGATTACGAGTGTATCTGACAAAGGAATTGGAAT
TTCAGAAGAAGATATTAATCATCTTTTTGAGCGTTTCTTTAGAGCGGACAAGGCTCGCAATCGAGAAATTGGTGGAACTG
GTTTAGGTTTATCAATTTTAGCTCGATTGGCAGAAAATTATCAAGGGGAAATTGAGGTAAATTCAGAACTGGGTCTTGGT
TCAACTTTTACACTAAAATTCCCGAAAATAAAATAA

Domains

Predicted by InterproScan.

ArlS sensor domain (ArlS_N)

(54-185)

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c)

(380-489)

HAMP domain (HAMP)

(208-258)

His Kinase A (phospho-acceptor) domain (HisKA)

(267-332)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A2A9ICZ0

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  covS Lactococcus lactis subsp. lactis strain DGCC12653

100

100

1

Multiple sequence alignment