Detailed information NTG0107335

Bioinformatically predicted

Overview

• Name: comEA/celA/cilE
• Type: Machinery gene
• Locus tag: ACAM22_RS06145
• Genome accession: NZ_AP028929
• Coordinates: 1361841..1362491 (-)
• Length: 216 a.a.
• NCBI ID: WP_265471425.1
• Uniprot ID: -
• Organism: Streptococcus sp. SN-1
• Function: dsDNA binding to the cell surface (predicted from homology) DNA binding and uptake

Genomic Context

Location: 1356841..1367491

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ACAM22_RS06120 (MASAN616_12020)	-	1357784..1358164 (-)	381	WP_153226519.1	VOC family protein	-
ACAM22_RS06125 (MASAN616_12030)	rplT	1358223..1358582 (-)	360	WP_000124834.1	50S ribosomal protein L20	-
ACAM22_RS06130 (MASAN616_12040)	rpmI	1358634..1358834 (-)	201	WP_001125943.1	50S ribosomal protein L35	-
ACAM22_RS06135 (MASAN616_12050)	infC	1358867..1359397 (-)	531	WP_000848180.1	translation initiation factor IF-3	-
ACAM22_RS06140 (MASAN616_12060)	-	1359617..1361857 (-)	2241	Protein_1216	DNA internalization-related competence protein ComEC/Rec2	-
ACAM22_RS06145 (MASAN616_12070)	comEA/celA/cilE	1361841..1362491 (-)	651	WP_265471425.1	helix-hairpin-helix domain-containing protein	Machinery gene
ACAM22_RS06150 (MASAN616_12080)	-	1362558..1363127 (-)	570	WP_261050264.1	GNAT family N-acetyltransferase	-
ACAM22_RS06155 (MASAN616_12090)	-	1363243..1364217 (-)	975	WP_261050265.1	PhoH family protein	-
ACAM22_RS06160 (MASAN616_12100)	-	1364302..1364517 (-)	216	WP_261050267.1	YozE family protein	-
ACAM22_RS06165 (MASAN616_12110)	cvfB	1364526..1365380 (-)	855	WP_369606517.1	RNA-binding virulence regulatory protein CvfB	-
ACAM22_RS06170 (MASAN616_12120)	frr	1365440..1365997 (-)	558	WP_175913643.1	ribosome recycling factor	-
ACAM22_RS06175 (MASAN616_12130)	pyrH	1366006..1366743 (-)	738	WP_000002996.1	UMP kinase	-

Sequence

Protein

• Length: 216 a.a.
• Molecular weight: 23176.59 Da
• Isoelectric Point: 7.9589

>NTDB_id=107335 ACAM22_RS06145 WP_265471425.1 1361841..1362491(-) (comEA/celA/cilE) [Streptococcus sp. SN-1]
MEAIIEKIKEYKIIVICTGLGLLVGGFFLLKPAPQTPIKETNLQAEVAAISKDSVSEKEVKKEKNAEPLEQDLITVDVKG
AVKAPGIYDLPVGSRVNDAVQKAGGLTEQADSKSLNLAQKVSDEALVYVPTKGEEVASQQTTSGTASSTSKEKKVNLNKA
SLEELKQVKGLGGKRAQDIIDHREANGKFKSVDELKKVSGIGAKTIEKLKDYVTVD

Nucleotide

• Length: 651 bp

>NTDB_id=107335 ACAM22_RS06145 WP_265471425.1 1361841..1362491(-) (comEA/celA/cilE) [Streptococcus sp. SN-1]
ATGGAAGCAATTATCGAGAAAATCAAAGAGTATAAAATCATTGTCATCTGTACTGGTCTGGGGTTACTTGTCGGAGGATT
TTTCCTGCTAAAGCCAGCTCCACAAACACCTATAAAGGAAACGAATTTACAGGCAGAAGTCGCAGCTATTTCCAAGGATT
CGGTGTCCGAAAAGGAAGTGAAGAAGGAAAAAAATGCAGAACCCCTTGAACAAGATCTAATCACAGTAGATGTGAAGGGT
GCTGTTAAAGCGCCAGGAATTTATGATTTGCCAGTAGGGAGTCGGGTCAATGACGCCGTTCAGAAAGCAGGTGGTTTGAC
AGAGCAAGCAGACAGCAAGTCGCTCAATCTAGCTCAGAAAGTCAGTGATGAGGCTCTGGTTTACGTTCCAACTAAGGGAG
AAGAAGTAGCTAGTCAACAGACTACTTCGGGGACAGCTTCTTCGACGAGCAAGGAAAAAAAGGTCAATCTCAACAAGGCC
AGTCTGGAAGAACTCAAGCAGGTCAAGGGACTGGGAGGAAAACGAGCTCAGGACATTATCGATCATCGTGAGGCAAATGG
GAAATTTAAGTCGGTTGATGAACTCAAGAAAGTCTCTGGAATTGGTGCCAAGACCATAGAAAAGCTAAAAGACTATGTTA
CAGTGGATTAA

Domains

Predicted by InterproScan.

• SLBB domain (SLBB) (76-126)

• Helix-hairpin-helix motif (HHH_3) (151-214)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comEA/celA/cilE	Streptococcus mitis NCTC 12261	94.907	100	0.949
comEA/celA/cilE	Streptococcus pneumoniae TIGR4	94.444	100	0.944
comEA/celA/cilE	Streptococcus pneumoniae D39	93.519	100	0.935
comEA/celA/cilE	Streptococcus pneumoniae R6	93.519	100	0.935
comEA/celA/cilE	Streptococcus pneumoniae Rx1	93.519	100	0.935
comEA/celA/cilE	Streptococcus mitis SK321	90.741	100	0.907
comEA	Lactococcus lactis subsp. cremoris KW2	42.222	100	0.44
comEA	Latilactobacillus sakei subsp. sakei 23K	33.613	100	0.37
comEA	Staphylococcus aureus N315	34.821	100	0.361