Detailed information    

insolico Bioinformatically predicted

Overview

Name   comE   Type   Regulator
Locus tag   ACAM22_RS00030 Genome accession   NZ_AP028929
Coordinates   2840..3592 (+) Length   250 a.a.
NCBI ID   WP_000866065.1    Uniprot ID   -
Organism   Streptococcus sp. SN-1     
Function   activate transcription of early competence genes (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
IS/Tn 3842..5098 2840..3592 flank 250


Gene organization within MGE regions


Location: 2840..5098
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ACAM22_RS00030 (MASAN616_00040) comE 2840..3592 (+) 753 WP_000866065.1 competence system response regulator transcription factor ComE Regulator
  ACAM22_RS00045 (MASAN616_00050) - 3842..5098 (-) 1257 WP_265471657.1 ISL3 family transposase -

Sequence

Protein


Download         Length: 250 a.a.        Molecular weight: 29958.31 Da        Isoelectric Point: 6.5073

>NTDB_id=107297 ACAM22_RS00030 WP_000866065.1 2840..3592(+) (comE) [Streptococcus sp. SN-1]
MKVLILEDVIEHQVRLERILDEISKESNIPISYKTTGKVREFEEYIENDEVNQLYFLDIDIHGIEKKGFEVAQLIRHYNP
YAIIVFITSRSEFATLTYKYQVSALDFVDKDINDEMFKKRIEQNIFYTKSMLLENEDVVDYFDYNYKGNDLKIPYHDILY
IETTGVSHKLRIIGKNFAKEFYGTMTDIQEKDKHTQRFYSPHKSFLVNIGNIREIDRKNLEIVFYEDHRCPISRLKIRKL
KDILEKKSQK

Nucleotide


Download         Length: 753 bp        

>NTDB_id=107297 ACAM22_RS00030 WP_000866065.1 2840..3592(+) (comE) [Streptococcus sp. SN-1]
ATGAAAGTTTTAATTTTAGAGGATGTTATTGAACATCAAGTGAGACTAGAAAGAATATTGGATGAAATTTCGAAAGAATC
GAATATTCCAATATCATACAAGACAACAGGAAAAGTCCGTGAATTTGAAGAATACATTGAAAATGATGAAGTAAATCAGC
TTTATTTCCTAGATATCGATATTCATGGAATTGAGAAAAAAGGATTTGAGGTTGCTCAGCTCATTCGTCATTACAATCCC
TACGCTATTATCGTCTTTATCACCAGTCGATCAGAGTTTGCGACTTTAACCTATAAATACCAGGTATCAGCTCTAGATTT
TGTTGATAAGGATATCAATGATGAGATGTTTAAGAAGAGAATTGAGCAAAATATTTTTTACACGAAGAGTATGTTACTTG
AAAATGAAGATGTTGTAGATTATTTTGATTACAATTACAAGGGAAATGATTTAAAAATTCCTTACCATGATATTTTGTAT
ATTGAAACGACAGGAGTCTCTCATAAATTGCGCATTATTGGTAAGAATTTTGCCAAAGAGTTCTATGGTACCATGACAGA
TATTCAGGAAAAGGACAAACATACTCAGCGATTTTATTCTCCTCATAAGTCATTTTTGGTAAATATAGGCAATATTAGAG
AAATTGACCGAAAGAATCTAGAAATTGTTTTCTATGAAGACCATCGTTGTCCTATTTCAAGGTTAAAAATTAGAAAATTG
AAAGATATTTTAGAGAAAAAATCTCAAAAGTGA

Domains

Predicted by InterproScan.

LytTr DNA-binding domain (LytTR)

(151-244)

Response regulator receiver domain (Response_reg)

(3-121)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comE Streptococcus pneumoniae Rx1

100

100

1
  comE Streptococcus pneumoniae D39

100

100

1
  comE Streptococcus pneumoniae R6

100

100

1
  comE Streptococcus pneumoniae TIGR4

100

100

1
  comE Streptococcus mitis SK321

99.2

100

0.992
  comE Streptococcus mitis NCTC 12261

98.4

100

0.984
  comE Streptococcus infantis strain Atu-4

91.2

100

0.912
  comE/comE2 Streptococcus gordonii strain NCTC7865

62.8

100

0.628
  comE/comE1 Streptococcus gordonii str. Challis substr. CH1

62.8

100

0.628
  comE/blpR Streptococcus mutans UA159

41.296

98.8

0.408

Multiple sequence alignment