Detailed information NTG0106633

Bioinformatically predicted

Overview

• Name: comE
• Type: Regulator
• Locus tag: AABJ45_RS11470
• Genome accession: NZ_AP028611
• Coordinates: 2238336..2239073 (-)
• Length: 245 a.a.
• NCBI ID: WP_338372085.1
• Uniprot ID: -
• Organism: Streptococcus pneumoniae strain Sep6
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type	MGE coordinates	Gene coordinates	Relative position	Distance (bp)
IS/Tn	2237380..2238333	2238336..2239073	flank	3

Gene organization within MGE regions

Location: 2237380..2239073

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
AABJ45_RS11465 (TKY121527_22360)	-	2237380..2238333 (+)	954	WP_001155321.1	IS30-like element ISSpn8 family transposase	-
AABJ45_RS11470 (TKY121527_22370)	comE	2238336..2239073 (-)	738	WP_338372085.1	competence system response regulator transcription factor ComE	Regulator

Sequence

Protein

• Length: 245 a.a.
• Molecular weight: 29304.49 Da
• Isoelectric Point: 6.1046

>NTDB_id=106633 AABJ45_RS11470 WP_338372085.1 2238336..2239073(-) (comE) [Streptococcus pneumoniae strain Sep6]
MKVLILEDVIEHQVRLERILDEISKESNIPISYKTTGKVREFEEYIENDEVNQLYFLDIDIHGIEKKGFEVVQLIRHYNP
YAIIVFITSRSEFATLTYKYQVSALDFVDKDINDEMFKKRIEQNIFYTKSMLLENEDVVDYFDYNYKGNDLKIPYHDILY
IETTGVSHKLRIIGKNFAKEFYGTMTDIQEKDKHTQRFYSPHKSFLVNIGNIREIDRKNLEIVFYEDHRCPISRLKIRKL
TQISS

Nucleotide

• Length: 738 bp

>NTDB_id=106633 AABJ45_RS11470 WP_338372085.1 2238336..2239073(-) (comE) [Streptococcus pneumoniae strain Sep6]
ATGAAAGTTTTAATTTTAGAAGATGTTATTGAACATCAAGTGAGACTAGAGAGAATATTGGATGAAATTTCGAAAGAATC
GAATATTCCAATATCATACAAGACAACGGGAAAAGTCCGTGAATTTGAAGAATACATTGAAAATGATGAAGTAAATCAGC
TTTATTTCCTAGATATCGATATTCATGGAATTGAGAAAAAGGGATTTGAAGTGGTTCAGCTCATTCGTCATTACAATCCT
TACGCTATTATCGTCTTTATCACTAGTCGATCAGAGTTTGCGACTCTAACCTATAAATACCAGGTATCAGCCCTAGATTT
TGTTGATAAGGATATCAATGATGAGATGTTTAAGAAGAGAATTGAGCAAAATATCTTCTACACGAAGAGTATGTTACTTG
AAAATGAAGATGTTGTAGATTATTTCGACTACAATTACAAGGGAAATGATTTAAAAATTCCTTACCATGATATTTTGTAT
ATTGAAACAACAGGGGTATCTCATAAATTGCGCATTATTGGTAAGAATTTTGCAAAAGAGTTTTATGGTACCATGACAGA
TATTCAGGAAAAGGACAAACATACTCAGCGATTTTATTCTCCTCACAAGTCATTTTTGGTAAATATAGGTAATATCAGAG
AAATTGATCGAAAAAACTTAGAAATTGTTTTCTATGAAGACCATCGTTGTCCTATTTCAAGATTAAAAATTAGAAAATTA
ACCCAAATTTCAAGTTGA

Domains

Predicted by InterproScan.

• LytTr DNA-binding domain (LytTR) (151-243)

• Response regulator receiver domain (Response_reg) (3-121)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE	Streptococcus pneumoniae Rx1	98.765	99.184	0.98
comE	Streptococcus pneumoniae D39	98.765	99.184	0.98
comE	Streptococcus pneumoniae R6	98.765	99.184	0.98
comE	Streptococcus pneumoniae TIGR4	98.765	99.184	0.98
comE	Streptococcus mitis SK321	97.942	99.184	0.971
comE	Streptococcus mitis NCTC 12261	97.119	99.184	0.963
comE	Streptococcus infantis strain Atu-4	90.535	99.184	0.898
comE/comE2	Streptococcus gordonii strain NCTC7865	62.14	99.184	0.616
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	62.14	99.184	0.616
comE/blpR	Streptococcus mutans UA159	41.057	100	0.412