Detailed information NTG0106554

Bioinformatically predicted

Overview

• Name: comE
• Type: Regulator
• Locus tag: AABA16_RS10655
• Genome accession: NZ_AP028610
• Coordinates: 2060671..2061423 (-)
• Length: 250 a.a.
• NCBI ID: WP_000866065.1
• Uniprot ID: -
• Organism: Streptococcus pneumoniae strain Sep5
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2055671..2066423

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
AABA16_RS10635	-	2058109..2059758 (-)	1650	Protein_2056	YhgE/Pip domain-containing protein	-
AABA16_RS10640 (TKY124516_20580)	-	2059886..2060428 (+)	543	WP_001158266.1	TetR/AcrR family transcriptional regulator	-
AABA16_RS10655 (TKY124516_20590)	comE	2060671..2061423 (-)	753	WP_000866065.1	competence system response regulator transcription factor ComE	Regulator
AABA16_RS10660 (TKY124516_20600)	comD/comD1	2061420..2062745 (-)	1326	WP_001853914.1	competence system sensor histidine kinase ComD	Regulator
AABA16_RS10665 (TKY124516_20610)	comC/comC1	2062766..2062891 (-)	126	WP_000799689.1	competence-stimulating peptide ComC	Regulator
AABA16_RS10675 (TKY124516_20620)	rlmH	2063174..2063653 (-)	480	WP_000695930.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
AABA16_RS10680 (TKY124516_20630)	htrA	2063836..2065017 (+)	1182	WP_000681597.1	trypsin-like peptidase domain-containing protein	Regulator
AABA16_RS10685 (TKY124516_20640)	spo0J	2065075..2065833 (+)	759	WP_000410380.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 250 a.a.
• Molecular weight: 29958.31 Da
• Isoelectric Point: 6.5073

>NTDB_id=106554 AABA16_RS10655 WP_000866065.1 2060671..2061423(-) (comE) [Streptococcus pneumoniae strain Sep5]
MKVLILEDVIEHQVRLERILDEISKESNIPISYKTTGKVREFEEYIENDEVNQLYFLDIDIHGIEKKGFEVAQLIRHYNP
YAIIVFITSRSEFATLTYKYQVSALDFVDKDINDEMFKKRIEQNIFYTKSMLLENEDVVDYFDYNYKGNDLKIPYHDILY
IETTGVSHKLRIIGKNFAKEFYGTMTDIQEKDKHTQRFYSPHKSFLVNIGNIREIDRKNLEIVFYEDHRCPISRLKIRKL
KDILEKKSQK

Nucleotide

• Length: 753 bp

>NTDB_id=106554 AABA16_RS10655 WP_000866065.1 2060671..2061423(-) (comE) [Streptococcus pneumoniae strain Sep5]
ATGAAAGTTTTAATTTTAGAAGATGTTATTGAACATCAAGTGAGACTAGAGAGAATATTGGATGAAATTTCGAAAGAATC
GAATATTCCAATATCATACAAGACAACGGGAAAAGTCCGTGAATTTGAAGAATACATTGAAAATGATGAAGTAAATCAGC
TTTATTTCCTAGATATCGATATTCATGGAATTGAGAAAAAGGGATTTGAAGTGGCTCAGCTCATTCGTCATTACAATCCT
TACGCTATTATCGTCTTTATCACTAGTCGATCAGAGTTTGCGACTCTAACCTATAAATACCAGGTATCAGCCCTAGATTT
TGTTGATAAGGATATCAATGATGAGATGTTTAAGAAGAGAATTGAGCAAAATATCTTCTACACGAAGAGTATGTTACTTG
AAAATGAAGATGTTGTAGATTATTTCGACTACAATTACAAGGGAAATGATTTAAAAATTCCTTACCATGATATTTTGTAT
ATTGAAACAACAGGGGTATCTCATAAATTGCGCATTATTGGTAAGAATTTTGCAAAAGAGTTTTATGGTACCATGACAGA
TATTCAGGAAAAGGACAAACATACTCAGCGATTTTATTCTCCTCACAAGTCATTTTTGGTAAATATAGGCAATATCAGAG
AAATTGATCGAAAAAACTTAGAAATTGTTTTCTATGAAGACCATCGTTGTCCTATTTCAAGATTAAAAATTAGAAAATTA
AAAGATATTTTAGAGAAAAAATCTCAAAAGTGA

Domains

Predicted by InterproScan.

• LytTr DNA-binding domain (LytTR) (151-244)

• Response regulator receiver domain (Response_reg) (3-121)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE	Streptococcus pneumoniae Rx1	100	100	1
comE	Streptococcus pneumoniae D39	100	100	1
comE	Streptococcus pneumoniae R6	100	100	1
comE	Streptococcus pneumoniae TIGR4	100	100	1
comE	Streptococcus mitis SK321	99.2	100	0.992
comE	Streptococcus mitis NCTC 12261	98.4	100	0.984
comE	Streptococcus infantis strain Atu-4	91.2	100	0.912
comE/comE2	Streptococcus gordonii strain NCTC7865	62.8	100	0.628
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	62.8	100	0.628
comE/blpR	Streptococcus mutans UA159	41.296	98.8	0.408