Detailed information NTG0106324

Bioinformatically predicted

Overview

• Name: comE
• Type: Regulator
• Locus tag: AABA14_RS11125
• Genome accession: NZ_AP028607
• Coordinates: 2137637..2138389 (-)
• Length: 250 a.a.
• NCBI ID: WP_000866065.1
• Uniprot ID: -
• Organism: Streptococcus pneumoniae strain Sep2
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2132637..2143389

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
AABA14_RS11100 (TKY123642_21490)	-	2132986..2135538 (+)	2553	WP_000834682.1	YfhO family protein	-
AABA14_RS11105	-	2135568..2136745 (-)	1178	Protein_2149	YhgE/Pip family protein	-
AABA14_RS11110 (TKY123642_21520)	-	2136852..2137394 (+)	543	WP_001158266.1	TetR/AcrR family transcriptional regulator	-
AABA14_RS11125 (TKY123642_21530)	comE	2137637..2138389 (-)	753	WP_000866065.1	competence system response regulator transcription factor ComE	Regulator
AABA14_RS11130 (TKY123642_21540)	comD/comD1	2138386..2139711 (-)	1326	WP_000362880.1	competence system sensor histidine kinase ComD	Regulator
AABA14_RS11135 (TKY123642_21550)	comC/comC1	2139732..2139857 (-)	126	WP_000799689.1	competence-stimulating peptide ComC	Regulator
AABA14_RS11145 (TKY123642_21560)	rlmH	2140139..2140618 (-)	480	WP_000695929.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
AABA14_RS11150 (TKY123642_21570)	htrA	2140801..2141982 (+)	1182	WP_000681601.1	S1C family serine protease	Regulator
AABA14_RS11155 (TKY123642_21580)	spo0J	2142040..2142798 (+)	759	WP_000410385.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 250 a.a.
• Molecular weight: 29958.31 Da
• Isoelectric Point: 6.5073

>NTDB_id=106324 AABA14_RS11125 WP_000866065.1 2137637..2138389(-) (comE) [Streptococcus pneumoniae strain Sep2]
MKVLILEDVIEHQVRLERILDEISKESNIPISYKTTGKVREFEEYIENDEVNQLYFLDIDIHGIEKKGFEVAQLIRHYNP
YAIIVFITSRSEFATLTYKYQVSALDFVDKDINDEMFKKRIEQNIFYTKSMLLENEDVVDYFDYNYKGNDLKIPYHDILY
IETTGVSHKLRIIGKNFAKEFYGTMTDIQEKDKHTQRFYSPHKSFLVNIGNIREIDRKNLEIVFYEDHRCPISRLKIRKL
KDILEKKSQK

Nucleotide

• Length: 753 bp

>NTDB_id=106324 AABA14_RS11125 WP_000866065.1 2137637..2138389(-) (comE) [Streptococcus pneumoniae strain Sep2]
ATGAAAGTTTTAATTTTAGAAGATGTTATTGAACATCAAGTGAGACTAGAGAGAATATTGGATGAAATTTCGAAAGAATC
GAATATTCCAATATCATACAAGACAACGGGAAAAGTCCGTGAATTTGAAGAATACATTGAAAATGATGAAGTAAATCAGC
TTTATTTCCTAGATATCGATATTCATGGAATTGAGAAAAAGGGATTTGAAGTGGCTCAGCTCATTCGTCATTACAATCCT
TACGCTATTATCGTCTTTATCACTAGTCGATCAGAGTTTGCGACTCTAACCTATAAATATCAGGTATCAGCCCTAGATTT
TGTTGATAAGGATATCAATGATGAGATGTTTAAGAAGAGAATTGAGCAAAATATCTTCTACACGAAGAGTATGTTACTTG
AAAATGAAGATGTTGTAGATTATTTCGACTACAATTACAAGGGAAATGATTTAAAAATTCCTTACCATGATATTTTGTAT
ATTGAAACAACAGGGGTATCTCATAAATTGCGCATTATTGGTAAGAATTTTGCAAAAGAGTTTTATGGTACCATGACAGA
TATTCAGGAAAAGGACAAACATACTCAGCGATTTTATTCTCCTCACAAGTCATTTTTGGTAAATATAGGCAATATCAGAG
AAATTGATCGAAAAAACTTAGAAATTGTTTTCTATGAAGACCATCGTTGTCCTATTTCAAGATTAAAAATTAGAAAATTA
AAAGATATTTTAGAGAAAAAATCTCAAAAGTGA

Domains

Predicted by InterproScan.

• LytTr DNA-binding domain (LytTR) (151-244)

• Response regulator receiver domain (Response_reg) (3-121)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE	Streptococcus pneumoniae Rx1	100	100	1
comE	Streptococcus pneumoniae D39	100	100	1
comE	Streptococcus pneumoniae R6	100	100	1
comE	Streptococcus pneumoniae TIGR4	100	100	1
comE	Streptococcus mitis SK321	99.2	100	0.992
comE	Streptococcus mitis NCTC 12261	98.4	100	0.984
comE	Streptococcus infantis strain Atu-4	91.2	100	0.912
comE/comE2	Streptococcus gordonii strain NCTC7865	62.8	100	0.628
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	62.8	100	0.628
comE/blpR	Streptococcus mutans UA159	41.296	98.8	0.408