Detailed information NTG0106245

Bioinformatically predicted

Overview

• Name: comE
• Type: Regulator
• Locus tag: AAA996_RS10790
• Genome accession: NZ_AP028606
• Coordinates: 2100128..2100880 (-)
• Length: 250 a.a.
• NCBI ID: WP_000866065.1
• Uniprot ID: -
• Organism: Streptococcus pneumoniae strain Sep1
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2095128..2105880

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
AAA996_RS10770	-	2097561..2099164 (-)	1604	Protein_2083	YhgE/Pip domain-containing protein	-
AAA996_RS10775 (TKY121773_20840)	-	2099343..2099885 (+)	543	WP_001158266.1	TetR/AcrR family transcriptional regulator	-
AAA996_RS10790 (TKY121773_20850)	comE	2100128..2100880 (-)	753	WP_000866065.1	competence system response regulator transcription factor ComE	Regulator
AAA996_RS10795 (TKY121773_20860)	comD/comD1	2100877..2102202 (-)	1326	WP_001850878.1	competence system sensor histidine kinase ComD	Regulator
AAA996_RS10800 (TKY121773_20870)	comC/comC1	2102223..2102348 (-)	126	WP_000799689.1	competence-stimulating peptide ComC	Regulator
AAA996_RS10810 (TKY121773_20880)	rlmH	2102630..2103109 (-)	480	WP_000695929.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
AAA996_RS10815 (TKY121773_20890)	htrA	2103292..2104473 (+)	1182	WP_000681601.1	S1C family serine protease	Regulator
AAA996_RS10820 (TKY121773_20900)	spo0J	2104531..2105289 (+)	759	WP_000410378.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 250 a.a.
• Molecular weight: 29958.31 Da
• Isoelectric Point: 6.5073

>NTDB_id=106245 AAA996_RS10790 WP_000866065.1 2100128..2100880(-) (comE) [Streptococcus pneumoniae strain Sep1]
MKVLILEDVIEHQVRLERILDEISKESNIPISYKTTGKVREFEEYIENDEVNQLYFLDIDIHGIEKKGFEVAQLIRHYNP
YAIIVFITSRSEFATLTYKYQVSALDFVDKDINDEMFKKRIEQNIFYTKSMLLENEDVVDYFDYNYKGNDLKIPYHDILY
IETTGVSHKLRIIGKNFAKEFYGTMTDIQEKDKHTQRFYSPHKSFLVNIGNIREIDRKNLEIVFYEDHRCPISRLKIRKL
KDILEKKSQK

Nucleotide

• Length: 753 bp

>NTDB_id=106245 AAA996_RS10790 WP_000866065.1 2100128..2100880(-) (comE) [Streptococcus pneumoniae strain Sep1]
ATGAAAGTTTTAATTTTAGAAGATGTTATTGAACATCAAGTGAGACTAGAGAGAATATTGGATGAAATTTCGAAAGAATC
GAATATTCCAATATCATACAAGACAACGGGAAAAGTCCGTGAATTTGAAGAATACATTGAAAATGATGAAGTAAATCAGC
TTTATTTCCTAGATATCGATATTCATGGAATTGAGAAAAAGGGATTTGAAGTGGCTCAGCTCATTCGTCATTACAATCCT
TACGCTATTATCGTCTTTATCACTAGTCGATCAGAGTTTGCGACTCTAACCTATAAATACCAGGTATCAGCCCTAGATTT
TGTTGATAAGGATATCAATGATGAGATGTTTAAGAAGAGAATTGAGCAAAATATCTTCTACACGAAGAGTATGTTACTTG
AAAATGAAGATGTTGTAGATTATTTCGACTACAATTACAAGGGAAATGATTTAAAAATTCCTTACCATGATATTTTGTAT
ATTGAAACAACAGGGGTCTCTCATAAATTGCGCATTATTGGTAAGAATTTTGCAAAAGAGTTTTATGGTACCATGACAGA
TATTCAGGAAAAGGACAAACATACTCAGCGATTTTATTCTCCTCACAAGTCATTTTTGGTAAATATAGGCAATATCAGAG
AAATTGATCGAAAAAACTTAGAAATTGTTTTCTATGAAGACCATCGTTGTCCTATTTCAAGATTAAAAATTAGAAAATTA
AAAGATATTTTAGAGAAAAAATCTCAAAAGTGA

Domains

Predicted by InterproScan.

• LytTr DNA-binding domain (LytTR) (151-244)

• Response regulator receiver domain (Response_reg) (3-121)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE	Streptococcus pneumoniae Rx1	100	100	1
comE	Streptococcus pneumoniae D39	100	100	1
comE	Streptococcus pneumoniae R6	100	100	1
comE	Streptococcus pneumoniae TIGR4	100	100	1
comE	Streptococcus mitis SK321	99.2	100	0.992
comE	Streptococcus mitis NCTC 12261	98.4	100	0.984
comE	Streptococcus infantis strain Atu-4	91.2	100	0.912
comE/comE2	Streptococcus gordonii strain NCTC7865	62.8	100	0.628
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	62.8	100	0.628
comE/blpR	Streptococcus mutans UA159	41.296	98.8	0.408