Detailed information    

insolico Bioinformatically predicted

Overview

Name   cinA   Type   Machinery gene
Locus tag   ACB350_RS08855 Genome accession   NZ_CP166999
Coordinates   1757017..1758288 (-) Length   423 a.a.
NCBI ID   WP_030127534.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain Isolate 34     
Function   require for competence (predicted from homology)   
Unclear

Genomic Context

Location: 1752017..1763288
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ACB350_RS08830 (ACB350_08825) - 1753988..1754293 (-) 306 WP_002982199.1 DUF1292 domain-containing protein -
  ACB350_RS08835 (ACB350_08830) ruvX 1754305..1754724 (-) 420 WP_002982196.1 Holliday junction resolvase RuvX -
  ACB350_RS08840 (ACB350_08835) - 1754721..1754990 (-) 270 WP_002982194.1 IreB family regulatory phosphoprotein -
  ACB350_RS08845 (ACB350_08840) spx 1755104..1755502 (-) 399 WP_002982188.1 transcriptional regulator Spx -
  ACB350_RS08850 (ACB350_08845) recA 1755792..1756928 (-) 1137 WP_002992179.1 recombinase RecA Machinery gene
  ACB350_RS08855 (ACB350_08850) cinA 1757017..1758288 (-) 1272 WP_030127534.1 competence/damage-inducible protein A Machinery gene
  ACB350_RS08860 (ACB350_08855) - 1758357..1758917 (-) 561 WP_030127533.1 DNA-3-methyladenine glycosylase I -
  ACB350_RS08865 (ACB350_08860) ruvA 1758927..1759523 (-) 597 WP_002982180.1 Holliday junction branch migration protein RuvA -
  ACB350_RS08870 (ACB350_08865) - 1759525..1760745 (-) 1221 WP_030127532.1 MFS transporter -
  ACB350_RS08875 (ACB350_08870) mutL 1760756..1762738 (-) 1983 WP_002992189.1 DNA mismatch repair endonuclease MutL -

Sequence

Protein


Download         Length: 423 a.a.        Molecular weight: 45989.71 Da        Isoelectric Point: 4.9060

>NTDB_id=1036780 ACB350_RS08855 WP_030127534.1 1757017..1758288(-) (cinA) [Streptococcus pyogenes strain Isolate 34]
MKAELIAVGTEILTGQIVNTNAQFLSEKMAELGIDVYFQTAVGDNEERLLSVITTASHRSDLVILCGGLGPTKDDLTKQT
LAKYLRKDLVYDEQACQKLDDFFAKRKPSSRTPNNERQAQVIEGSISLPNKTGLAVGGFITVDGISYVVLPGPPSELKPM
VNEELVPLLSKQYSTLYSKVLRFFGIGESQLVTVLSDFIENQTDPTIAPYAKTGEVTLRLSTKTENQALADKKLGQLEAQ
LLSRKTLEGQPLADVFYGYGEDNSLARETFELLVKYDKTITAAESLTAGLFQSTLASFPGASQVFNGGFVTYSMEEKAKM
LGLPLEELKSHGVVSAYTAEGMAEQARLLTGADIGVSLTGVAGPDMLEEQPAGTVFIGLATQNKVESIKVLISGRSRLDV
RYIATLHAFNMVRKTLLKLENLL

Nucleotide


Download         Length: 1272 bp        

>NTDB_id=1036780 ACB350_RS08855 WP_030127534.1 1757017..1758288(-) (cinA) [Streptococcus pyogenes strain Isolate 34]
ATGAAAGCTGAACTGATTGCAGTAGGTACCGAAATTTTGACTGGTCAAATTGTGAATACCAATGCTCAATTTCTGTCGGA
AAAAATGGCAGAGCTAGGTATTGATGTCTATTTTCAAACGGCTGTTGGGGACAACGAGGAGCGTTTACTTTCAGTGATTA
CAACTGCTAGTCATCGTAGTGACTTGGTGATTTTATGTGGTGGCCTTGGTCCAACGAAAGATGATTTAACCAAACAAACT
TTAGCAAAGTACCTTAGGAAAGACTTGGTTTATGATGAGCAAGCTTGTCAGAAACTAGATGACTTTTTTGCTAAGCGCAA
GCCTTCATCACGGACACCAAATAATGAGCGACAGGCACAAGTGATTGAAGGGTCAATCTCTTTGCCAAATAAAACTGGTC
TTGCGGTTGGTGGGTTCATCACAGTCGATGGTATTAGTTATGTTGTCTTACCGGGTCCTCCAAGTGAATTGAAGCCGATG
GTAAATGAAGAATTGGTACCACTTCTGTCAAAACAATACAGTACATTGTATTCAAAGGTACTACGCTTTTTTGGTATTGG
GGAAAGTCAGTTGGTAACAGTCTTGTCAGATTTTATTGAGAATCAAACTGATCCAACCATTGCTCCGTATGCTAAGACTG
GCGAAGTGACTCTTCGCTTATCAACAAAAACTGAAAACCAAGCTCTGGCAGATAAAAAGTTAGGTCAGCTAGAAGCGCAG
CTACTATCCCGAAAAACTCTTGAAGGTCAACCCTTAGCTGATGTCTTTTATGGCTATGGGGAGGATAATTCCTTAGCGCG
TGAGACATTTGAGCTCTTAGTAAAATATGATAAGACAATTACAGCAGCAGAAAGTCTAACCGCGGGATTATTTCAGTCAA
CTTTGGCGAGTTTTCCAGGAGCTTCTCAAGTATTCAATGGAGGCTTTGTGACTTATAGCATGGAAGAAAAAGCGAAAATG
CTAGGCCTTCCTTTAGAGGAGTTGAAATCGCATGGCGTTGTTAGTGCTTATACAGCCGAGGGGATGGCGGAGCAAGCAAG
GTTATTGACTGGTGCTGATATTGGGGTAAGTTTAACAGGTGTTGCCGGACCAGATATGTTGGAGGAACAGCCTGCAGGTA
CAGTTTTCATTGGCCTTGCCACTCAAAATAAGGTAGAATCAATAAAGGTTTTGATTAGCGGGCGAAGTCGTTTGGATGTG
CGCTATATCGCTACTTTACATGCCTTTAATATGGTCCGTAAAACTTTATTAAAACTTGAGAATTTGCTATAA

Domains

Predicted by InterproScan.

Probable molybdopterin binding domain (MoCF_biosynth)

(5-170)

Competence-damaged protein (CinA)

(263-416)

Damage-inducible protein CinA KH domain (CinA_KH)

(178-243)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  cinA Streptococcus mutans UA159

69.504

100

0.695
  cinA Streptococcus mitis SK321

69.544

98.582

0.686
  cinA Streptococcus mitis NCTC 12261

69.065

98.582

0.681
  cinA Streptococcus pneumoniae TIGR4

68.106

98.582

0.671
  cinA Streptococcus pneumoniae Rx1

68.106

98.582

0.671
  cinA Streptococcus pneumoniae R6

68.106

98.582

0.671
  cinA Streptococcus pneumoniae D39

67.866

98.582

0.669
  cinA Streptococcus suis isolate S10

53.125

98.345

0.522
  cinA Bacillus subtilis subsp. subtilis str. 168

46.651

98.818

0.461

Multiple sequence alignment