Detailed information NTG1013823

Bioinformatically predicted

Overview

• Name: covR
• Type: Regulator
• Locus tag: ABVR74_RS04180
• Genome accession: NZ_CP159484
• Coordinates: 801978..802670 (+)
• Length: 230 a.a.
• NCBI ID: WP_003130756.1
• Uniprot ID: S6EZK2
• Organism: Lactococcus lactis subsp. lactis strain CBA3648
• Function: repress the expression of comX (predicted from homology) Competence regulation

Genomic Context

Location: 796978..807670

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ABVR74_RS04150 (ABVR74_04150)	-	797766..798602 (+)	837	WP_353891823.1	metallophosphoesterase	-
ABVR74_RS04155 (ABVR74_04155)	-	798715..799626 (+)	912	WP_058223280.1	CHAP domain-containing protein	-
ABVR74_RS04160 (ABVR74_04160)	-	799852..800214 (+)	363	WP_023188700.1	TIGR02328 family protein	-
ABVR74_RS04165 (ABVR74_04165)	-	800296..800760 (+)	465	WP_353891824.1	hypothetical protein	-
ABVR74_RS04170 (ABVR74_04170)	-	800916..801161 (+)	246	WP_003130760.1	type B 50S ribosomal protein L31	-
ABVR74_RS04175 (ABVR74_04175)	-	801292..801822 (+)	531	WP_274998381.1	DUF177 domain-containing protein	-
ABVR74_RS04180 (ABVR74_04180)	covR	801978..802670 (+)	693	WP_003130756.1	response regulator transcription factor	Regulator
ABVR74_RS04185 (ABVR74_04185)	covS	802679..804154 (+)	1476	WP_010906048.1	HAMP domain-containing histidine kinase	Regulator
ABVR74_RS04190 (ABVR74_04190)	-	804337..805578 (+)	1242	WP_353891825.1	ammonium transporter	-
ABVR74_RS04195 (ABVR74_04195)	-	805710..806051 (+)	342	WP_010906046.1	P-II family nitrogen regulator	-

Sequence

Protein

• Length: 230 a.a.
• Molecular weight: 26684.36 Da
• Isoelectric Point: 5.1273

>NTDB_id=1013823 ABVR74_RS04180 WP_003130756.1 801978..802670(+) (covR) [Lactococcus lactis subsp. lactis strain CBA3648]
MTSKKILIIEDEKNLARFVSLELEHEGYATEIKDNGRSGLEEATSKDYDLILLDLMLPELDGFEVARRLRKEKDTPIIMM
TARDSTMDRVAGLDIGADDYITKPFAIEELLARVRAFFRREEHGHAVERAENTSFRDLVIDKTNRTVHRGKKVIDLTRRE
YDLLLTLMQNVGDVVTREHLVSQVWGYEEGTETNVVDVYIRYLRNKIDVEGQDSYIQTVRGLGYVMRERK

Nucleotide

• Length: 693 bp

>NTDB_id=1013823 ABVR74_RS04180 WP_003130756.1 801978..802670(+) (covR) [Lactococcus lactis subsp. lactis strain CBA3648]
ATGACTTCAAAGAAAATTTTGATTATTGAGGATGAAAAGAATTTAGCGCGATTCGTCTCATTAGAATTAGAACATGAAGG
CTATGCGACTGAGATTAAAGATAATGGTCGTTCTGGTCTTGAAGAAGCAACTTCAAAAGATTATGATTTAATCTTGCTTG
ATTTGATGCTTCCTGAACTTGACGGTTTTGAGGTAGCCCGTCGTTTACGAAAAGAAAAAGATACACCAATCATTATGATG
ACGGCACGTGATTCAACGATGGACCGTGTTGCTGGTCTTGATATTGGGGCTGATGATTATATCACTAAACCTTTTGCGAT
TGAGGAACTTTTGGCGCGTGTTCGTGCTTTCTTCCGTCGTGAAGAGCATGGTCATGCCGTTGAACGTGCTGAAAATACTT
CTTTCCGTGATCTTGTGATTGACAAAACGAATCGCACAGTTCATCGTGGTAAAAAAGTAATTGATTTAACACGTCGTGAG
TATGACCTCCTTTTGACATTGATGCAAAATGTTGGCGATGTTGTGACTCGTGAACATTTAGTTTCACAAGTTTGGGGATA
TGAAGAAGGAACAGAAACAAATGTTGTGGATGTTTATATTCGTTATCTTAGAAATAAAATTGATGTTGAAGGTCAAGATA
GCTATATTCAAACTGTTCGTGGCTTAGGTTATGTAATGCGTGAACGCAAATAA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (6-115)

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (153-226)

3D structure

• AlphaFold DB: S6EZK2

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
covR	Lactococcus lactis subsp. lactis strain DGCC12653	100	100	1
covR	Streptococcus salivarius strain HSISS4	68.421	99.13	0.678
vicR	Streptococcus mutans UA159	45.887	100	0.461
micA	Streptococcus pneumoniae Cp1015	43.478	100	0.435
ciaR	Streptococcus mutans UA159	37.611	98.261	0.37
ciaR	Streptococcus pneumoniae Rx1	36.726	98.261	0.361
ciaR	Streptococcus pneumoniae D39	36.726	98.261	0.361
ciaR	Streptococcus pneumoniae R6	36.726	98.261	0.361
ciaR	Streptococcus pneumoniae TIGR4	36.726	98.261	0.361