Detailed information NTG1011011

Bioinformatically predicted

Overview

• Name: covR
• Type: Regulator
• Locus tag: LLUC023_RS08370
• Genome accession: NZ_CP158368
• Coordinates: 1644826..1645518 (-)
• Length: 230 a.a.
• NCBI ID: WP_011676631.1
• Uniprot ID: A0A0M2ZTN8
• Organism: Lactococcus cremoris strain UC023
• Function: repress the expression of comX (predicted from homology) Competence regulation

Genomic Context

Location: 1639826..1650518

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
LLUC023_RS08350 (LLUC023_08360)	murD	1639970..1641319 (-)	1350	WP_021211936.1	UDP-N-acetylmuramoyl-L-alanine--D-glutamate ligase	-
LLUC023_RS08355 (LLUC023_08365)	-	1641488..1641829 (-)	342	WP_011676628.1	P-II family nitrogen regulator	-
LLUC023_RS08360 (LLUC023_08370)	-	1641914..1643155 (-)	1242	WP_021211937.1	ammonium transporter	-
LLUC023_RS08365 (LLUC023_08375)	covS	1643341..1644813 (-)	1473	WP_021211938.1	HAMP domain-containing histidine kinase	Regulator
LLUC023_RS08370 (LLUC023_08380)	covR	1644826..1645518 (-)	693	WP_011676631.1	response regulator transcription factor	Regulator
LLUC023_RS08375 (LLUC023_08385)	-	1645674..1646204 (-)	531	WP_011834860.1	DUF177 domain-containing protein	-
LLUC023_RS08380 (LLUC023_08390)	-	1646337..1646582 (-)	246	WP_011676633.1	type B 50S ribosomal protein L31	-
LLUC023_RS08385 (LLUC023_08395)	-	1646906..1647268 (-)	363	Protein_1634	TIGR02328 family protein	-
LLUC023_RS08390 (LLUC023_08400)	-	1647505..1648416 (-)	912	Protein_1635	CHAP domain-containing protein	-
LLUC023_RS08395 (LLUC023_08405)	-	1648509..1649345 (-)	837	WP_031288631.1	metallophosphoesterase	-
LLUC023_RS08400 (LLUC023_08410)	arsC	1649457..1649861 (-)	405	WP_282667596.1	arsenate reductase (thioredoxin)	-

Sequence

Protein

• Length: 230 a.a.
• Molecular weight: 26654.33 Da
• Isoelectric Point: 5.1273

>NTDB_id=1011011 LLUC023_RS08370 WP_011676631.1 1644826..1645518(-) (covR) [Lactococcus cremoris strain UC023]
MASKKILIIEDEKNLARFVSLELEHEGYATEIKDNGRSGLEEATSKDYDLILLDLMLPELDGFEVARRLRKEKDTPIIMM
TARDSTMDRVAGLDIGADDYITKPFAIEELLARVRAFFRREEHGHAVERAENTSFRDLVIDKTNRTVHRGKKVIDLTRRE
YDLLLTLMQNVGDVVTREHLVSQVWGYEEGTETNVVDVYIRYLRNKIDVEGQDSYIQTVRGLGYVMRERK

Nucleotide

• Length: 693 bp

>NTDB_id=1011011 LLUC023_RS08370 WP_011676631.1 1644826..1645518(-) (covR) [Lactococcus cremoris strain UC023]
ATGGCATCAAAGAAAATTTTGATTATTGAGGATGAAAAGAATTTAGCTCGTTTCGTCTCATTAGAATTAGAGCATGAAGG
CTATGCCACTGAGATTAAAGATAACGGACGTTCTGGGCTTGAAGAAGCAACTTCAAAAGATTATGATTTAATCTTGCTTG
ATTTGATGCTTCCTGAACTTGATGGTTTTGAAGTTGCCCGCCGTTTGCGCAAAGAAAAAGATACTCCAATTATTATGATG
ACCGCGCGTGATTCAACAATGGACCGTGTTGCCGGTCTTGATATTGGAGCAGATGATTATATTACTAAGCCTTTTGCGAT
TGAAGAACTTTTGGCTCGTGTTCGTGCATTCTTCCGTCGTGAAGAACATGGTCATGCTGTAGAACGTGCTGAAAACACTT
CTTTTCGTGATCTTGTAATTGACAAAACAAATCGTACCGTTCACCGCGGTAAAAAAGTAATTGATTTGACGCGTCGTGAA
TACGATCTTCTTTTGACGTTGATGCAAAATGTTGGGGATGTTGTCACTCGCGAACATTTAGTTTCACAAGTTTGGGGATA
TGAAGAAGGAACGGAAACAAATGTTGTTGATGTATATATCCGCTATCTTAGAAATAAAATTGATGTTGAAGGACAAGACA
GCTATATTCAAACCGTTCGTGGTTTGGGTTATGTGATGCGTGAACGCAAATAA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (6-115)

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (153-226)

3D structure

• AlphaFold DB: A0A0M2ZTN8

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
covR	Lactococcus lactis subsp. lactis strain DGCC12653	99.565	100	0.996
covR	Streptococcus salivarius strain HSISS4	68.421	99.13	0.678
vicR	Streptococcus mutans UA159	45.887	100	0.461
micA	Streptococcus pneumoniae Cp1015	43.478	100	0.435
ciaR	Streptococcus mutans UA159	37.611	98.261	0.37
ciaR	Streptococcus pneumoniae Rx1	36.726	98.261	0.361
ciaR	Streptococcus pneumoniae D39	36.726	98.261	0.361
ciaR	Streptococcus pneumoniae R6	36.726	98.261	0.361
ciaR	Streptococcus pneumoniae TIGR4	36.726	98.261	0.361