Detailed information NTG1006148

Bioinformatically predicted

Overview

• Name: htrA
• Type: Regulator
• Locus tag: FGL23_RS10655
• Genome accession: NZ_LR594049
• Coordinates: 2183330..2184523 (+)
• Length: 397 a.a.
• NCBI ID: WP_061603308.1
• Uniprot ID: -
• Organism: Streptococcus gordonii strain NCTC10231
• Function: repress competence development (predicted from homology) Competence regulation

Genomic Context

Location: 2178330..2189523

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
FGL23_RS10615 (NCTC10231_02125)	ychF	2178641..2179756 (-)	1116	WP_008808030.1	redox-regulated ATPase YchF	-
FGL23_RS10630 (NCTC10231_02128)	comE/comE2	2180078..2180845 (-)	768	WP_008808031.1	competence system response regulator transcription factor ComE	Regulator
FGL23_RS10635 (NCTC10231_02129)	comD/comD1	2180842..2182203 (-)	1362	WP_061603310.1	competence system sensor histidine kinase ComD	Regulator
FGL23_RS10640 (NCTC10231_02130)	comC/comC1	2182219..2182371 (-)	153	WP_012131079.1	bacteriocin	Regulator
FGL23_RS10650 (NCTC10231_02132)	rlmH	2182657..2183136 (-)	480	WP_061603309.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
FGL23_RS10655 (NCTC10231_02133)	htrA	2183330..2184523 (+)	1194	WP_061603308.1	S1C family serine protease	Regulator
FGL23_RS10660 (NCTC10231_02134)	spo0J	2184589..2185353 (+)	765	WP_061601400.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 397 a.a.
• Molecular weight: 42182.88 Da
• Isoelectric Point: 5.4898

>NTDB_id=1006148 FGL23_RS10655 WP_061603308.1 2183330..2184523(+) (htrA) [Streptococcus gordonii strain NCTC10231]
MKNSSNFFKKTLQVFIILFVGFIGGVAGTWGLSYFSTPHSATNNNQKTATTITTSYKNSNSTTKAVDKVKDAVVSVITYS
ESSSDAIFDNNNSGNENDQVASEGSGVIYRKDKDYAYLVTNTHVINGAKKVDIRLADGNKVPGEIVGTDTYSDISVVRIP
ADKVKNVAEFGDSSKLTVGETAIAIGSPLGSDYANTVTQGIVSSLSRNVSSRSEDGQTIATQAIQTDAAINPGNSGGPLV
NIQGQVIGITSSKIANTNNGSTSVEGMGFAIPSNDVVNIIEQLEKNGKVIRPALGIQMVNLSSLSSSSSDRLKLPDNVKN
GVVVRSTQTGMPADGKLQKYDVITKIDDTEISSASDIQSALYKHSINEEIKVTYYRDGKEQTTTIKLTKSTDDLSSE

Nucleotide

• Length: 1194 bp

>NTDB_id=1006148 FGL23_RS10655 WP_061603308.1 2183330..2184523(+) (htrA) [Streptococcus gordonii strain NCTC10231]
ATGAAAAATTCTTCAAATTTCTTCAAAAAAACATTGCAAGTTTTCATTATCTTGTTTGTTGGTTTTATAGGTGGTGTTGC
TGGAACATGGGGACTTTCTTATTTTTCAACACCTCACTCAGCCACAAATAATAATCAGAAAACAGCTACTACAATAACAA
CATCCTATAAAAATAGTAATTCTACAACAAAGGCTGTTGATAAAGTTAAAGACGCAGTTGTCTCTGTCATTACATATTCT
GAATCTAGTTCAGATGCTATTTTTGACAACAATAATTCAGGAAACGAAAATGATCAGGTAGCTAGCGAAGGATCTGGTGT
TATCTATAGAAAAGATAAAGACTATGCTTACTTAGTTACCAATACACACGTTATCAATGGAGCAAAAAAGGTTGATATCC
GTCTTGCTGATGGGAATAAGGTTCCTGGTGAAATAGTCGGAACTGATACATATTCTGATATTTCTGTAGTCAGAATTCCT
GCTGATAAGGTTAAAAATGTGGCTGAATTTGGGGATTCTAGTAAATTAACTGTTGGAGAAACTGCCATTGCAATCGGAAG
CCCTCTTGGTTCTGATTATGCTAATACAGTAACTCAGGGAATTGTTTCTAGTCTAAGCCGTAATGTTTCTTCACGATCAG
AAGATGGTCAGACAATTGCTACTCAAGCTATTCAAACTGATGCAGCAATTAATCCAGGTAACTCTGGTGGTCCTCTTGTA
AACATTCAAGGTCAAGTTATTGGTATTACCTCTAGTAAAATTGCTAACACCAATAATGGTAGTACTTCTGTTGAGGGAAT
GGGATTTGCAATCCCATCCAATGATGTTGTAAATATCATTGAACAATTAGAAAAGAATGGTAAAGTCATTCGACCAGCAT
TAGGAATTCAAATGGTCAACTTAAGTAGTTTGTCTTCTTCAAGCTCTGATCGATTAAAACTTCCAGACAATGTTAAAAAT
GGTGTCGTTGTTCGTTCAACACAAACTGGAATGCCTGCTGATGGTAAGTTACAAAAATATGATGTGATTACAAAAATTGA
TGATACAGAAATATCATCTGCTAGTGATATCCAATCAGCTCTTTATAAACATTCGATTAATGAAGAAATAAAAGTTACTT
ATTACCGTGATGGAAAAGAGCAAACAACAACTATTAAACTAACTAAATCAACTGATGATTTAAGCTCTGAATAA

Domains

Predicted by InterProScan.

• Trypsin-like peptidase domain (Trypsin_2) (104-249)

• PDZ domain (PDZ_2) (292-387)

• Peptidase family M50 (Peptidase_M50) (235-391)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
htrA	Streptococcus gordonii str. Challis substr. CH1	98.237	100	0.982
htrA	Streptococcus mitis NCTC 12261	65.829	100	0.66
htrA	Streptococcus pneumoniae Rx1	65.909	99.748	0.657
htrA	Streptococcus pneumoniae D39	65.909	99.748	0.657
htrA	Streptococcus pneumoniae R6	65.909	99.748	0.657
htrA	Streptococcus pneumoniae TIGR4	65.909	99.748	0.657
htrA	Streptococcus mutans UA159	55.89	100	0.562