Detailed information NTG1006145

Bioinformatically predicted

Overview

• Name: comE/comE2
• Type: Regulator
• Locus tag: FGL23_RS10630
• Genome accession: NZ_LR594049
• Coordinates: 2180078..2180845 (-)
• Length: 255 a.a.
• NCBI ID: WP_008808031.1
• Uniprot ID: P75031
• Organism: Streptococcus gordonii strain NCTC10231
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2175078..2185845

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
FGL23_RS10610 (NCTC10231_02124)	pth	2177998..2178567 (-)	570	WP_061603311.1	aminoacyl-tRNA hydrolase	-
FGL23_RS10615 (NCTC10231_02125)	ychF	2178641..2179756 (-)	1116	WP_008808030.1	redox-regulated ATPase YchF	-
FGL23_RS10630 (NCTC10231_02128)	comE/comE2	2180078..2180845 (-)	768	WP_008808031.1	competence system response regulator transcription factor ComE	Regulator
FGL23_RS10635 (NCTC10231_02129)	comD/comD1	2180842..2182203 (-)	1362	WP_061603310.1	competence system sensor histidine kinase ComD	Regulator
FGL23_RS10640 (NCTC10231_02130)	comC/comC1	2182219..2182371 (-)	153	WP_012131079.1	bacteriocin	Regulator
FGL23_RS10650 (NCTC10231_02132)	rlmH	2182657..2183136 (-)	480	WP_061603309.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
FGL23_RS10655 (NCTC10231_02133)	htrA	2183330..2184523 (+)	1194	WP_061603308.1	S1C family serine protease	Regulator
FGL23_RS10660 (NCTC10231_02134)	spo0J	2184589..2185353 (+)	765	WP_061601400.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 255 a.a.
• Molecular weight: 30225.48 Da
• Isoelectric Point: 7.0651

>NTDB_id=1006145 FGL23_RS10630 WP_008808031.1 2180078..2180845(-) (comE/comE2) [Streptococcus gordonii strain NCTC10231]
MKVLVLEDTIEHQVRIENVFEEISRELNLEIKAKVTGKIHEFKEYVESDEVNQLYFLDIDIKGEEQKGLEMAQFIRQHNP
YAIIVFVTSHSEFATLTFKYKVSALDFIDKDINDNSFKKRVKDCIVYTRNNLIENTDIVDFFEYSFRGNEIRIPFRDILY
IETTGSPYKLRVVGKNFFKEFYGTIAEIQEQDKELGYFFSPHKSYLSNISNISGYDKKTKDVLYYDGHRSPISRLRVRYL
KEILKAKSKKEENKK

Nucleotide

• Length: 768 bp

>NTDB_id=1006145 FGL23_RS10630 WP_008808031.1 2180078..2180845(-) (comE/comE2) [Streptococcus gordonii strain NCTC10231]
ATGAAAGTATTAGTGCTAGAAGATACTATTGAACATCAAGTGAGAATTGAAAATGTCTTCGAAGAAATTTCTCGCGAACT
AAATCTTGAAATTAAAGCAAAAGTAACAGGAAAAATTCATGAATTTAAAGAATATGTTGAGTCAGACGAGGTAAATCAAC
TCTATTTCTTAGATATAGATATCAAAGGAGAAGAACAAAAAGGTCTAGAAATGGCGCAATTTATACGCCAACATAATCCC
TATGCTATCATTGTTTTTGTCACGAGTCATTCAGAATTTGCGACTTTAACTTTTAAGTATAAAGTATCAGCGTTAGATTT
TATAGATAAAGACATAAATGATAATTCTTTTAAGAAAAGAGTTAAAGATTGCATCGTTTATACACGAAATAATTTAATTG
AAAATACAGATATTGTTGACTTTTTTGAGTATAGTTTTAGAGGAAACGAAATTCGAATTCCTTTTAGAGATATTTTATAT
ATTGAGACAACAGGAAGTCCTTATAAATTAAGAGTTGTTGGAAAAAATTTCTTTAAGGAATTCTATGGGACAATAGCAGA
AATTCAAGAACAAGATAAAGAACTTGGATATTTTTTCTCACCACACAAGTCATACCTATCTAATATTAGTAATATTAGTG
GATACGATAAAAAGACAAAAGATGTTTTGTATTATGATGGTCATCGTTCACCAATTTCTCGATTACGTGTCAGATATTTA
AAAGAAATACTGAAAGCAAAAAGTAAAAAAGAAGAAAATAAAAAATAA

Domains

Predicted by InterProScan.

• LytTr DNA-binding domain (LytTR) (151-244)

• Response regulator receiver domain (Response_reg) (3-121)

3D structure

• AlphaFold DB: P75031

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/comE2	Streptococcus gordonii strain NCTC7865	100	100	1
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	100	100	1
comE	Streptococcus infantis strain Atu-4	64	98.039	0.627
comE	Streptococcus mitis NCTC 12261	64	98.039	0.627
comE	Streptococcus mitis SK321	63.2	98.039	0.62
comE	Streptococcus pneumoniae Rx1	62.8	98.039	0.616
comE	Streptococcus pneumoniae D39	62.8	98.039	0.616
comE	Streptococcus pneumoniae R6	62.8	98.039	0.616
comE	Streptococcus pneumoniae TIGR4	62.8	98.039	0.616
comE/blpR	Streptococcus mutans UA159	37.551	96.078	0.361