24732

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pasABC/-
Location 19251..19734 Replicon plasmid pXF-RIV11
Accession NC_014111
Organism Xylella fastidiosa

Toxin (Protein)


Gene name pasB Uniprot ID A0A060HFL1
Locus tag HS687_RS00120 Protein ID WP_014607314.1
Coordinates 19251..19520 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name pasA Uniprot ID A0A060HE94
Locus tag HS687_RS00125 Protein ID WP_038211605.1
Coordinates 19504..19734 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HS687_RS00075 (pXFRIV11_p18) 15724..16107 - 384 WP_013087959.1 VirB3 family type IV secretion system protein -
HS687_RS00080 (pXFRIV11_p19) 16112..16432 - 321 WP_013087960.1 TrbC/VirB2 family protein -
HS687_RS00085 (pXFRIV11_p20) 16435..16914 - 480 WP_080679721.1 hypothetical protein -
HS687_RS00090 16917..17117 - 201 WP_024748608.1 hypothetical protein -
HS687_RS00095 17169..17417 - 249 WP_038230319.1 hypothetical protein -
HS687_RS00100 17691..17834 + 144 WP_254224883.1 hypothetical protein -
HS687_RS00105 17922..18281 + 360 WP_038211603.1 hypothetical protein -
HS687_RS00110 (pXFRIV11_p23) 18375..19046 - 672 WP_013087963.1 restriction endonuclease -
HS687_RS00115 19071..19199 + 129 WP_234056444.1 type II toxin-antitoxin system PemK/MazF family toxin -
HS687_RS00120 19251..19520 - 270 WP_014607314.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HS687_RS00125 (pXFRIV11_p24) 19504..19734 - 231 WP_038211605.1 DUF6290 family protein Antitoxin
HS687_RS00130 (pXFRIV11_p25) 19911..20513 + 603 WP_013087965.1 recombinase family protein -
HS687_RS00135 (pXFRIV11_p26) 20540..21376 + 837 WP_013087966.1 plasmid replication initiator TrfA -
HS687_RS00140 (pXFRIV11_p28) 21820..22056 + 237 WP_013087968.1 antitoxin MazE family protein -
HS687_RS00145 (pXFRIV11_p29) 22053..22380 + 328 Protein_28 type II toxin-antitoxin system PemK/MazF family toxin -
HS687_RS00150 (pXFRIV11_p30) 22485..22928 - 444 WP_014607318.1 hypothetical protein -
HS687_RS00155 (pXFRIV11_p31) 22929..23681 - 753 WP_013087971.1 hypothetical protein -
HS687_RS00160 (pXFRIV11_p32) 23694..24050 - 357 WP_013087972.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Non-Mobilizable plasmid - - 1..25105 25105


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-88)

Antitoxin

Protein of unknown function DUF6290

(1-70)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10252.86 Da        Isoelectric Point: 9.9871

>T24732 WP_014607314.1 NC_014111:c19520-19251 [Xylella fastidiosa]
MAWKVELSSLAQKNLDQLDPQIALRVLSFLHERVAPLDDPRSIGESLKGSRLGEFWKYRVGDYRIISSIEDGALRILVVK
IGNRREVYR

Download         Length: 270 bp

>T24732 NC_014111:c19520-19251 [Xylella fastidiosa]
ATGGCATGGAAGGTTGAGCTTTCGTCGTTGGCTCAAAAAAACCTTGATCAGCTTGACCCACAAATTGCCCTGCGTGTCCT
ATCATTTCTCCATGAGCGTGTGGCTCCTTTGGACGATCCGCGCAGCATCGGTGAATCCCTCAAGGGTTCGCGCCTTGGTG
AGTTTTGGAAGTACCGCGTGGGTGATTACCGGATTATCAGCAGCATTGAGGACGGCGCTTTGCGCATCCTCGTTGTGAAG
ATTGGCAACCGCCGCGAGGTTTACCGTTAG

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8686.80 Da        Isoelectric Point: 4.2465

>AT24732 WP_038211605.1 NC_014111:c19734-19504 [Xylella fastidiosa]
MASVSLRLPDEVTQRLENLAALTGRSKTFYMVEAIREHIDDLEDLYLAERELEAIRSGNSQTVPLEEVMQRYGMEG

Download         Length: 231 bp

>AT24732 NC_014111:c19734-19504 [Xylella fastidiosa]
ATGGCCTCCGTATCACTGCGTTTGCCTGATGAAGTTACACAACGACTTGAGAACTTAGCAGCGCTCACAGGGCGTAGCAA
AACCTTCTACATGGTGGAAGCCATCCGCGAACACATCGACGACCTAGAAGACTTGTACCTAGCCGAGCGTGAGCTTGAAG
CGATCCGTTCTGGCAATTCGCAAACCGTACCACTCGAAGAAGTGATGCAACGCTATGGCATGGAAGGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A060HFL1

Antitoxin

Source ID Structure
AlphaFold DB A0A060HE94

References