Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | pasABC/RelE-HTH |
Location | 19251..19734 | Replicon | plasmid pXF-Riv16 |
Accession | NZ_CP090317 | ||
Organism | Xylella fastidiosa subsp. morus strain Riv16 |
Toxin (Protein)
Gene name | pasB | Uniprot ID | A0A060HFL1 |
Locus tag | IUD23_RS12090 | Protein ID | WP_014607314.1 |
Coordinates | 19251..19520 (-) | Length | 90 a.a. |
Antitoxin (Protein)
Gene name | pasA | Uniprot ID | A0A060HE94 |
Locus tag | IUD23_RS12095 | Protein ID | WP_038211605.1 |
Coordinates | 19504..19734 (-) | Length | 77 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
IUD23_RS12055 (IUD23_12055) | 15724..16107 | - | 384 | WP_013087959.1 | VirB3 family type IV secretion system protein | - |
IUD23_RS12060 (IUD23_12060) | 16112..16432 | - | 321 | WP_013087960.1 | TrbC/VirB2 family protein | - |
IUD23_RS12065 (IUD23_12065) | 16435..16908 | - | 474 | WP_013087961.1 | hypothetical protein | - |
IUD23_RS12070 (IUD23_12070) | 16917..17096 | - | 180 | WP_014607310.1 | hypothetical protein | - |
IUD23_RS12075 (IUD23_12075) | 17922..18281 | + | 360 | WP_038211603.1 | hypothetical protein | - |
IUD23_RS12080 (IUD23_12080) | 18375..19046 | - | 672 | WP_013087963.1 | restriction endonuclease | - |
IUD23_RS12085 (IUD23_12085) | 19071..19199 | + | 129 | WP_234056444.1 | type II toxin-antitoxin system PemK/MazF family toxin | - |
IUD23_RS12090 (IUD23_12090) | 19251..19520 | - | 270 | WP_014607314.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
IUD23_RS12095 (IUD23_12095) | 19504..19734 | - | 231 | WP_038211605.1 | DUF6290 family protein | Antitoxin |
IUD23_RS12100 (IUD23_12100) | 19911..20513 | + | 603 | WP_013087965.1 | recombinase family protein | - |
IUD23_RS12105 (IUD23_12105) | 20510..21373 | + | 864 | WP_234056439.1 | plasmid replication initiator TrfA | - |
IUD23_RS12110 (IUD23_12110) | 21817..22053 | + | 237 | WP_013087968.1 | antitoxin MazE family protein | - |
IUD23_RS12115 (IUD23_12115) | 22050..22377 | + | 328 | Protein_28 | type II toxin-antitoxin system PemK/MazF family toxin | - |
IUD23_RS12120 (IUD23_12120) | 22482..22925 | - | 444 | WP_014607318.1 | hypothetical protein | - |
IUD23_RS12125 (IUD23_12125) | 22926..23678 | - | 753 | WP_013087971.1 | hypothetical protein | - |
IUD23_RS12130 (IUD23_12130) | 23691..23951 | - | 261 | WP_234056440.1 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
inside | Non-Mobilizable plasmid | - | - | 1..25102 | 25102 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 90 a.a. Molecular weight: 10252.86 Da Isoelectric Point: 9.9871
>T230437 WP_014607314.1 NZ_CP090317:c19520-19251 [Xylella fastidiosa subsp. morus]
MAWKVELSSLAQKNLDQLDPQIALRVLSFLHERVAPLDDPRSIGESLKGSRLGEFWKYRVGDYRIISSIEDGALRILVVK
IGNRREVYR
MAWKVELSSLAQKNLDQLDPQIALRVLSFLHERVAPLDDPRSIGESLKGSRLGEFWKYRVGDYRIISSIEDGALRILVVK
IGNRREVYR
Download Length: 270 bp
>T230437 NZ_CP124898:c2450268-2450152 [Enterococcus faecalis]
ATGTTTTTGTCCGTTGAAGCAGCGCTAGGACTGATGATTGGTTTTGCAACACTTGTTGTGACCATTATCTTCGGTATCTT
AGCGCTTGTCTTAGACAACAAAAATAACCGTTCATAA
ATGTTTTTGTCCGTTGAAGCAGCGCTAGGACTGATGATTGGTTTTGCAACACTTGTTGTGACCATTATCTTCGGTATCTT
AGCGCTTGTCTTAGACAACAAAAATAACCGTTCATAA
Antitoxin
Download Length: 77 a.a. Molecular weight: 8686.80 Da Isoelectric Point: 4.2465
>AT230437 WP_038211605.1 NZ_CP090317:c19734-19504 [Xylella fastidiosa subsp. morus]
MASVSLRLPDEVTQRLENLAALTGRSKTFYMVEAIREHIDDLEDLYLAERELEAIRSGNSQTVPLEEVMQRYGMEG
MASVSLRLPDEVTQRLENLAALTGRSKTFYMVEAIREHIDDLEDLYLAERELEAIRSGNSQTVPLEEVMQRYGMEG
Download Length: 231 bp
>AT230437 NZ_CP124898:2450036-2450241 [Enterococcus faecalis]
AAAAGAGAGATATGCAGGAACATACCTCTCTAATAGCCACTACTAGTTATAAGAACTAGCGGCTTACTGAGTTATTGGTT
TTATTTCAAACGCTTAACCGTTCAGCTCCTCAAAGCTTATGAACGGTTATTTTTGTTGTCTAAGACAAGCGCTAAGATAC
CGAAGATAATGGTCACAACAAGTGTTGCAAAACCAATCATCAGTCC
AAAAGAGAGATATGCAGGAACATACCTCTCTAATAGCCACTACTAGTTATAAGAACTAGCGGCTTACTGAGTTATTGGTT
TTATTTCAAACGCTTAACCGTTCAGCTCCTCAAAGCTTATGAACGGTTATTTTTGTTGTCTAAGACAAGCGCTAAGATAC
CGAAGATAATGGTCACAACAAGTGTTGCAAAACCAATCATCAGTCC
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A060HFL1 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A060HE94 |