Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/PRK09812-MazE
Location 1289..1875 Replicon plasmid pXF-Riv25
Accession NZ_CP090505
Organism Xylella fastidiosa subsp. morus strain Riv25

Toxin (Protein)


Gene name pemK Uniprot ID A0A060HFN7
Locus tag LZ755_RS12040 Protein ID WP_038230332.1
Coordinates 1549..1875 (+) Length 109 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID D5LL99
Locus tag LZ755_RS12035 Protein ID WP_013087943.1
Coordinates 1289..1552 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LZ755_RS12030 (LZ755_12030) 130..1230 + 1101 WP_013087942.1 zeta toxin family protein -
LZ755_RS12035 (LZ755_12035) 1289..1552 + 264 WP_013087943.1 antitoxin Antitoxin
LZ755_RS12040 (LZ755_12040) 1549..1875 + 327 WP_038230332.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
LZ755_RS12045 (LZ755_12045) 1934..3070 - 1137 WP_013087945.1 relaxase/mobilization nuclease domain-containing protein -
LZ755_RS12050 (LZ755_12050) 3136..4242 - 1107 WP_013087946.1 hypothetical protein -
LZ755_RS12055 (LZ755_12055) 4255..6531 - 2277 WP_013087947.1 type IV secretory system conjugative DNA transfer family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Non-Mobilizable plasmid - - 1..24372 24372


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-102)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 109 a.a.        Molecular weight: 11795.71 Da        Isoelectric Point: 8.5480

>T230921 WP_038230332.1 NZ_CP090505:1549-1875 [Xylella fastidiosa subsp. morus]
MKRGDVYMVDLEPTAGHEQRGHRPVVVISSERFNRLTSCPVILPITNGGEFASRLGFAVELLGTITTGVVRCDQPRALDL
LARNARKVESLPPNILADVLAKAVTIFQ

Download         Length: 327 bp

>T230921 NZ_CP125669:171378-171779 [Acinetobacter sp. KCTC 92772]
ATGCTGAAATATATGCTTGATACCAATATCGTTATTTATGTCATAAAACAAAAACCGCCGCAGGTACGAACCAAATTTAA
TAGCGTTGCCACACAGCTTTGTGTAAGTAGTGTGACTGTTGCCGAATTGATTTATGGTGCTGAAAACAGCCAATACCCTG
AAAAGAATCTATACATCGTTGAGAATTTTCTTTCACGGTTGCAGATATTGGATTATGGTCTGGAAGCTGCGATTCAGTAT
GGAAATATCAAGGCTATTCTTAGAAAAACTGGGCAGCTCATCAGTGATAATGATTTACATATTGCTGCCCACGCGCGAAG
TAAAGGTTTGATATTGGTGACCAACAATACGAAAGAGTTTGAACGTGTGCCTGCATTACAGTTAGAAAACTGGGTCGGAT
GA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9365.77 Da        Isoelectric Point: 4.3588

>AT230921 WP_013087943.1 NZ_CP090505:1289-1552 [Xylella fastidiosa subsp. morus]
MHTTNLRKVGGSIMLAVPPAFLDQLHLEVGATVGLAVTDGRLVIEPVLHPQYTLDQLLAEAEASGAYPLPPEEREWVDAP
AVGRELI

Download         Length: 264 bp

>AT230921 NZ_CP125669:171150-171377 [Acinetobacter sp. KCTC 92772]
ATGATTACATCTATATTCATGAATAATCGTACACAGGCGGTTCGATTACCAAGTGTCTACCGTTTTTCGGAACAGACACA
AAAAGTGTTTGTTCGTCAAATGGGAGTTGAGCGTGTAATTAGCCAAGTAGATCAGGTTTGGGATAGTTTTTTTGATAATC
CAGACTTAACTGTGTCTGACGATTTTGAGCGTGGAGAACAGCTCAATAGCGAGCGTGAGTCTTTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A060HFN7

Antitoxin

Source ID Structure
AlphaFold DB A0A060H856

References