230954

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pasABC/RelE-HTH
Location 19251..19734 Replicon plasmid pXF-Riv11
Accession NZ_CP090509
Organism Xylella fastidiosa subsp. morus strain Riv11

Toxin (Protein)


Gene name pasB Uniprot ID A0A060HFL1
Locus tag LZ758_RS12105 Protein ID WP_014607314.1
Coordinates 19251..19520 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name pasA Uniprot ID A0A060HE94
Locus tag LZ758_RS12110 Protein ID WP_038211605.1
Coordinates 19504..19734 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LZ758_RS12070 (LZ758_12070) 15724..16107 - 384 WP_013087959.1 VirB3 family type IV secretion system protein -
LZ758_RS12075 (LZ758_12075) 16112..16432 - 321 WP_013087960.1 TrbC/VirB2 family protein -
LZ758_RS12080 (LZ758_12080) 16435..16914 - 480 WP_080679721.1 hypothetical protein -
LZ758_RS12085 (LZ758_12085) 16917..17096 - 180 WP_014607310.1 hypothetical protein -
LZ758_RS12090 (LZ758_12090) 17922..18281 + 360 WP_038211603.1 hypothetical protein -
LZ758_RS12095 (LZ758_12095) 18375..19046 - 672 WP_013087963.1 restriction endonuclease -
LZ758_RS12100 (LZ758_12100) 19071..19199 + 129 WP_234056444.1 type II toxin-antitoxin system PemK/MazF family toxin -
LZ758_RS12105 (LZ758_12105) 19251..19520 - 270 WP_014607314.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LZ758_RS12110 (LZ758_12110) 19504..19734 - 231 WP_038211605.1 DUF6290 family protein Antitoxin
LZ758_RS12115 (LZ758_12115) 19911..20513 + 603 WP_013087965.1 recombinase family protein -
LZ758_RS12120 (LZ758_12120) 20510..21376 + 867 WP_128723949.1 plasmid replication initiator TrfA -
LZ758_RS12125 (LZ758_12125) 21820..22056 + 237 WP_013087968.1 antitoxin MazE family protein -
LZ758_RS12130 (LZ758_12130) 22053..22380 + 328 Protein_28 type II toxin-antitoxin system PemK/MazF family toxin -
LZ758_RS12135 (LZ758_12135) 22485..22928 - 444 WP_014607318.1 hypothetical protein -
LZ758_RS12140 (LZ758_12140) 22929..23681 - 753 WP_013087971.1 hypothetical protein -
LZ758_RS12145 (LZ758_12145) 23694..23954 - 261 WP_234056440.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Non-Mobilizable plasmid - - 1..25105 25105


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-88)

Antitoxin

Protein of unknown function DUF6290

(1-70)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10252.86 Da        Isoelectric Point: 9.9871

>T230954 WP_014607314.1 NZ_CP090509:c19520-19251 [Xylella fastidiosa subsp. morus]
MAWKVELSSLAQKNLDQLDPQIALRVLSFLHERVAPLDDPRSIGESLKGSRLGEFWKYRVGDYRIISSIEDGALRILVVK
IGNRREVYR

Download         Length: 270 bp

>T230954 NZ_CP125733:29475-29624 [Escherichia coli]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAACTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8686.80 Da        Isoelectric Point: 4.2465

>AT230954 WP_038211605.1 NZ_CP090509:c19734-19504 [Xylella fastidiosa subsp. morus]
MASVSLRLPDEVTQRLENLAALTGRSKTFYMVEAIREHIDDLEDLYLAERELEAIRSGNSQTVPLEEVMQRYGMEG

Download         Length: 231 bp

>AT230954 NZ_CP125733:c29431-29370 [Escherichia coli]
TTAAGGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A060HFL1

Antitoxin

Source ID Structure
AlphaFold DB A0A060HE94

References