Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/PRK09812-MazE
Location 1289..1875 Replicon plasmid pXF-Riv11
Accession NZ_CP090509
Organism Xylella fastidiosa subsp. morus strain Riv11

Toxin (Protein)


Gene name pemK Uniprot ID A0A060HFN7
Locus tag LZ758_RS12005 Protein ID WP_038230332.1
Coordinates 1549..1875 (+) Length 109 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID D5LL99
Locus tag LZ758_RS12000 Protein ID WP_013087943.1
Coordinates 1289..1552 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LZ758_RS11995 (LZ758_11995) 130..1230 + 1101 WP_013087942.1 zeta toxin family protein -
LZ758_RS12000 (LZ758_12000) 1289..1552 + 264 WP_013087943.1 antitoxin Antitoxin
LZ758_RS12005 (LZ758_12005) 1549..1875 + 327 WP_038230332.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
LZ758_RS12010 (LZ758_12010) 1934..3070 - 1137 WP_013087945.1 relaxase/mobilization nuclease domain-containing protein -
LZ758_RS12015 (LZ758_12015) 3136..4242 - 1107 WP_013087946.1 hypothetical protein -
LZ758_RS12020 (LZ758_12020) 4255..6531 - 2277 WP_013087947.1 type IV secretory system conjugative DNA transfer family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Non-Mobilizable plasmid - - 1..25105 25105


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-102)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 109 a.a.        Molecular weight: 11795.71 Da        Isoelectric Point: 8.5480

>T230953 WP_038230332.1 NZ_CP090509:1549-1875 [Xylella fastidiosa subsp. morus]
MKRGDVYMVDLEPTAGHEQRGHRPVVVISSERFNRLTSCPVILPITNGGEFASRLGFAVELLGTITTGVVRCDQPRALDL
LARNARKVESLPPNILADVLAKAVTIFQ

Download         Length: 327 bp

>T230953 NZ_CP125732:c39426-39274 [Escherichia coli]
ATGCCACAGCGAACGTTTTTAATGATGTTAATCGTCATCTGTGTGACGATTCTGTGTTTTGTCTGGATGGTGAGGGATTC
GCTTTGCGTACTCCGGCTCCAGCAGGGAAACACAGTGCTTGTGGCAACGTTAGCCTACGAAGTTAAACGTTAA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9365.77 Da        Isoelectric Point: 4.3588

>AT230953 WP_013087943.1 NZ_CP090509:1289-1552 [Xylella fastidiosa subsp. morus]
MHTTNLRKVGGSIMLAVPPAFLDQLHLEVGATVGLAVTDGRLVIEPVLHPQYTLDQLLAEAEASGAYPLPPEEREWVDAP
AVGRELI

Download         Length: 264 bp

>AT230953 NZ_CP125732:39476-39538 [Escherichia coli]
TCGAAGCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A060HFN7

Antitoxin

Source ID Structure
AlphaFold DB A0A060H856

References