Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | pemIK/PRK09812-MazE |
Location | 1289..1875 | Replicon | plasmid pXF-Riv11 |
Accession | NZ_CP090509 | ||
Organism | Xylella fastidiosa subsp. morus strain Riv11 |
Toxin (Protein)
Gene name | pemK | Uniprot ID | A0A060HFN7 |
Locus tag | LZ758_RS12005 | Protein ID | WP_038230332.1 |
Coordinates | 1549..1875 (+) | Length | 109 a.a. |
Antitoxin (Protein)
Gene name | pemI | Uniprot ID | D5LL99 |
Locus tag | LZ758_RS12000 | Protein ID | WP_013087943.1 |
Coordinates | 1289..1552 (+) | Length | 88 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
LZ758_RS11995 (LZ758_11995) | 130..1230 | + | 1101 | WP_013087942.1 | zeta toxin family protein | - |
LZ758_RS12000 (LZ758_12000) | 1289..1552 | + | 264 | WP_013087943.1 | antitoxin | Antitoxin |
LZ758_RS12005 (LZ758_12005) | 1549..1875 | + | 327 | WP_038230332.1 | type II toxin-antitoxin system PemK/MazF family toxin | Toxin |
LZ758_RS12010 (LZ758_12010) | 1934..3070 | - | 1137 | WP_013087945.1 | relaxase/mobilization nuclease domain-containing protein | - |
LZ758_RS12015 (LZ758_12015) | 3136..4242 | - | 1107 | WP_013087946.1 | hypothetical protein | - |
LZ758_RS12020 (LZ758_12020) | 4255..6531 | - | 2277 | WP_013087947.1 | type IV secretory system conjugative DNA transfer family protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
inside | Non-Mobilizable plasmid | - | - | 1..25105 | 25105 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 109 a.a. Molecular weight: 11795.71 Da Isoelectric Point: 8.5480
>T230953 WP_038230332.1 NZ_CP090509:1549-1875 [Xylella fastidiosa subsp. morus]
MKRGDVYMVDLEPTAGHEQRGHRPVVVISSERFNRLTSCPVILPITNGGEFASRLGFAVELLGTITTGVVRCDQPRALDL
LARNARKVESLPPNILADVLAKAVTIFQ
MKRGDVYMVDLEPTAGHEQRGHRPVVVISSERFNRLTSCPVILPITNGGEFASRLGFAVELLGTITTGVVRCDQPRALDL
LARNARKVESLPPNILADVLAKAVTIFQ
Download Length: 327 bp
>T230953 NZ_CP125732:c39426-39274 [Escherichia coli]
ATGCCACAGCGAACGTTTTTAATGATGTTAATCGTCATCTGTGTGACGATTCTGTGTTTTGTCTGGATGGTGAGGGATTC
GCTTTGCGTACTCCGGCTCCAGCAGGGAAACACAGTGCTTGTGGCAACGTTAGCCTACGAAGTTAAACGTTAA
ATGCCACAGCGAACGTTTTTAATGATGTTAATCGTCATCTGTGTGACGATTCTGTGTTTTGTCTGGATGGTGAGGGATTC
GCTTTGCGTACTCCGGCTCCAGCAGGGAAACACAGTGCTTGTGGCAACGTTAGCCTACGAAGTTAAACGTTAA
Antitoxin
Download Length: 88 a.a. Molecular weight: 9365.77 Da Isoelectric Point: 4.3588
>AT230953 WP_013087943.1 NZ_CP090509:1289-1552 [Xylella fastidiosa subsp. morus]
MHTTNLRKVGGSIMLAVPPAFLDQLHLEVGATVGLAVTDGRLVIEPVLHPQYTLDQLLAEAEASGAYPLPPEEREWVDAP
AVGRELI
MHTTNLRKVGGSIMLAVPPAFLDQLHLEVGATVGLAVTDGRLVIEPVLHPQYTLDQLLAEAEASGAYPLPPEEREWVDAP
AVGRELI
Download Length: 264 bp
>AT230953 NZ_CP125732:39476-39538 [Escherichia coli]
TCGAAGCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT
TCGAAGCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A060HFN7 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A060H856 |