45494

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pasABC/RelE-HTH
Location 6306..6789 Replicon plasmid unnamed2
Accession NZ_CP006739
Organism Xylella fastidiosa MUL0034

Toxin (Protein)


Gene name pasB Uniprot ID A0A060HFL1
Locus tag P303_RS00060 Protein ID WP_014607314.1
Coordinates 6520..6789 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name pasA Uniprot ID A0A060HE94
Locus tag P303_RS00055 Protein ID WP_038211605.1
Coordinates 6306..6536 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P303_RS00020 1990..2346 + 357 WP_013087972.1 hypothetical protein -
P303_RS00025 2359..3111 + 753 WP_013087971.1 hypothetical protein -
P303_RS00030 3112..3555 + 444 WP_014607318.1 hypothetical protein -
P303_RS00035 3660..3987 - 328 Protein_6 type II toxin-antitoxin system PemK/MazF family toxin -
P303_RS00040 3984..4220 - 237 WP_013087968.1 antitoxin MazE family protein -
P303_RS00045 4664..5530 - 867 WP_128723949.1 hypothetical protein -
P303_RS00050 5527..6129 - 603 WP_013087965.1 recombinase family protein -
P303_RS00055 6306..6536 + 231 WP_038211605.1 TraY domain-containing protein Antitoxin
P303_RS00060 6520..6789 + 270 WP_014607314.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
P303_RS13295 6874..6969 - 96 Protein_12 type II toxin-antitoxin system PemK/MazF family toxin -
P303_RS12035 7153..7665 + 513 WP_152534390.1 restriction endonuclease -
P303_RS13575 7759..8118 - 360 WP_038550784.1 hypothetical protein -
P303_RS00080 8943..9122 + 180 WP_080703189.1 hypothetical protein -
P303_RS00085 9125..9604 + 480 WP_080679721.1 hypothetical protein -
P303_RS00090 9607..9927 + 321 WP_013087960.1 TrbC/VirB2 family protein -
P303_RS00095 9932..10315 + 384 WP_013087959.1 VirB3 family type IV secretion system protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Non-Mobilizable plasmid - - 1..24391 24391


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-88)

Antitoxin

Protein of unknown function DUF6290

(1-70)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10252.86 Da        Isoelectric Point: 9.9871

>T45494 WP_014607314.1 NZ_CP006739:6520-6789 [Xylella fastidiosa MUL0034]
MAWKVELSSLAQKNLDQLDPQIALRVLSFLHERVAPLDDPRSIGESLKGSRLGEFWKYRVGDYRIISSIEDGALRILVVK
IGNRREVYR

Download         Length: 270 bp

>T45494 NZ_CP006739:6520-6789 [Xylella fastidiosa MUL0034]
ATGGCATGGAAGGTTGAGCTTTCGTCGTTGGCTCAAAAAAACCTTGATCAGCTTGACCCACAAATTGCCCTGCGTGTCCT
ATCATTTCTCCATGAGCGTGTGGCTCCTTTGGACGATCCGCGCAGCATCGGTGAATCCCTCAAGGGTTCGCGCCTTGGTG
AGTTTTGGAAGTACCGCGTGGGTGATTACCGGATTATCAGCAGCATTGAGGACGGCGCTTTGCGCATCCTCGTTGTGAAG
ATTGGCAACCGCCGCGAGGTTTACCGCTAG

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8686.80 Da        Isoelectric Point: 4.2465

>AT45494 WP_038211605.1 NZ_CP006739:6306-6536 [Xylella fastidiosa MUL0034]
MASVSLRLPDEVTQRLENLAALTGRSKTFYMVEAIREHIDDLEDLYLAERELEAIRSGNSQTVPLEEVMQRYGMEG

Download         Length: 231 bp

>AT45494 NZ_CP006739:6306-6536 [Xylella fastidiosa MUL0034]
ATGGCCTCCGTATCACTGCGTTTGCCTGATGAAGTTACACAACGACTTGAGAACTTAGCAGCGCTCACAGGGCGTAGCAA
AACCTTCTACATGGTGGAAGCCATCCGCGAACACATCGACGACCTAGAAGACTTGTACCTAGCCGAGCGTGAGCTTGAAG
CGATCCGTTCTGGCAATTCGCAAACCGTACCACTCGAAGAAGTGATGCAACGCTATGGCATGGAAGGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A060HFL1

Antitoxin

Source ID Structure
AlphaFold DB A0A060HE94

References