Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | pasABC/RelE-HTH |
| Location | 18518..19001 | Replicon | plasmid pXF-Riv19 |
| Accession | NZ_CP090507 | ||
| Organism | Xylella fastidiosa subsp. morus strain Riv19 | ||
Toxin (Protein)
| Gene name | pasB | Uniprot ID | A0A060HFL1 |
| Locus tag | LZ757_RS12095 | Protein ID | WP_014607314.1 |
| Coordinates | 18518..18787 (-) | Length | 90 a.a. |
Antitoxin (Protein)
| Gene name | pasA | Uniprot ID | A0A060HE94 |
| Locus tag | LZ757_RS12100 | Protein ID | WP_038211605.1 |
| Coordinates | 18771..19001 (-) | Length | 77 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LZ757_RS12060 (LZ757_12060) | 14992..15375 | - | 384 | WP_013087959.1 | VirB3 family type IV secretion system protein | - |
| LZ757_RS12065 (LZ757_12065) | 15380..15700 | - | 321 | WP_013087960.1 | TrbC/VirB2 family protein | - |
| LZ757_RS12070 (LZ757_12070) | 15703..16176 | - | 474 | WP_013087961.1 | hypothetical protein | - |
| LZ757_RS12075 (LZ757_12075) | 16185..16364 | - | 180 | WP_014607310.1 | hypothetical protein | - |
| LZ757_RS12080 (LZ757_12080) | 17189..17548 | + | 360 | WP_038211603.1 | hypothetical protein | - |
| LZ757_RS12085 (LZ757_12085) | 17642..18313 | - | 672 | WP_013087963.1 | restriction endonuclease | - |
| LZ757_RS12090 (LZ757_12090) | 18338..18466 | + | 129 | WP_234056444.1 | type II toxin-antitoxin system PemK/MazF family toxin | - |
| LZ757_RS12095 (LZ757_12095) | 18518..18787 | - | 270 | WP_014607314.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| LZ757_RS12100 (LZ757_12100) | 18771..19001 | - | 231 | WP_038211605.1 | DUF6290 family protein | Antitoxin |
| LZ757_RS12105 (LZ757_12105) | 19178..19780 | + | 603 | WP_013087965.1 | recombinase family protein | - |
| LZ757_RS12110 (LZ757_12110) | 19777..20643 | + | 867 | WP_128723949.1 | plasmid replication initiator TrfA | - |
| LZ757_RS12115 (LZ757_12115) | 21087..21323 | + | 237 | WP_013087968.1 | antitoxin MazE family protein | - |
| LZ757_RS12120 (LZ757_12120) | 21320..21647 | + | 328 | Protein_27 | type II toxin-antitoxin system PemK/MazF family toxin | - |
| LZ757_RS12125 (LZ757_12125) | 21752..22195 | - | 444 | WP_014607318.1 | hypothetical protein | - |
| LZ757_RS12130 (LZ757_12130) | 22196..22948 | - | 753 | WP_013087971.1 | hypothetical protein | - |
| LZ757_RS12135 (LZ757_12135) | 22961..23221 | - | 261 | WP_234056440.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| inside | Non-Mobilizable plasmid | - | - | 1..24372 | 24372 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 90 a.a. Molecular weight: 10252.86 Da Isoelectric Point: 9.9871
>T230938 WP_014607314.1 NZ_CP090507:c18787-18518 [Xylella fastidiosa subsp. morus]
MAWKVELSSLAQKNLDQLDPQIALRVLSFLHERVAPLDDPRSIGESLKGSRLGEFWKYRVGDYRIISSIEDGALRILVVK
IGNRREVYR
MAWKVELSSLAQKNLDQLDPQIALRVLSFLHERVAPLDDPRSIGESLKGSRLGEFWKYRVGDYRIISSIEDGALRILVVK
IGNRREVYR
Download Length: 270 bp
>T230938 NZ_CP125731:928935-929342 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCTGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCTGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA
Antitoxin
Download Length: 77 a.a. Molecular weight: 8686.80 Da Isoelectric Point: 4.2465
>AT230938 WP_038211605.1 NZ_CP090507:c19001-18771 [Xylella fastidiosa subsp. morus]
MASVSLRLPDEVTQRLENLAALTGRSKTFYMVEAIREHIDDLEDLYLAERELEAIRSGNSQTVPLEEVMQRYGMEG
MASVSLRLPDEVTQRLENLAALTGRSKTFYMVEAIREHIDDLEDLYLAERELEAIRSGNSQTVPLEEVMQRYGMEG
Download Length: 231 bp
>AT230938 NZ_CP125731:928688-928954 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A060HFL1 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A060HE94 |