Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/PRK09812-MazE
Location 1289..1875 Replicon plasmid pXF-Riv16
Accession NZ_CP090317
Organism Xylella fastidiosa subsp. morus strain Riv16

Toxin (Protein)


Gene name pemK Uniprot ID A0A060HFN7
Locus tag IUD23_RS11990 Protein ID WP_038230332.1
Coordinates 1549..1875 (+) Length 109 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID D5LL99
Locus tag IUD23_RS11985 Protein ID WP_013087943.1
Coordinates 1289..1552 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IUD23_RS11980 (IUD23_11980) 130..1230 + 1101 WP_013087942.1 zeta toxin family protein -
IUD23_RS11985 (IUD23_11985) 1289..1552 + 264 WP_013087943.1 antitoxin Antitoxin
IUD23_RS11990 (IUD23_11990) 1549..1875 + 327 WP_038230332.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
IUD23_RS11995 (IUD23_11995) 1934..3070 - 1137 WP_013087945.1 relaxase/mobilization nuclease domain-containing protein -
IUD23_RS12000 (IUD23_12000) 3136..4242 - 1107 WP_013087946.1 hypothetical protein -
IUD23_RS12005 (IUD23_12005) 4255..6531 - 2277 WP_013087947.1 type IV secretory system conjugative DNA transfer family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Non-Mobilizable plasmid - - 1..25102 25102


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-102)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 109 a.a.        Molecular weight: 11795.71 Da        Isoelectric Point: 8.5480

>T230436 WP_038230332.1 NZ_CP090317:1549-1875 [Xylella fastidiosa subsp. morus]
MKRGDVYMVDLEPTAGHEQRGHRPVVVISSERFNRLTSCPVILPITNGGEFASRLGFAVELLGTITTGVVRCDQPRALDL
LARNARKVESLPPNILADVLAKAVTIFQ

Download         Length: 327 bp

>T230436 NZ_CP124898:c1677887-1677024 [Enterococcus faecalis]
ATGGCAAATATAGTCAATTTTACTGACAAACAATTTGAGAATCGCTTAAATGATAATTTAGAAGAATTGATTCAAGGAAA
AAAAGCGGTTGAATCGCCAACCGCTTTTTTACTTGGTGGGCAACCAGGGTCAGGGAAAACCAGTTTGCGATCAGCAATTC
TTGAAGAAACACAAGGGAATGTTATTGTCATTGATAATGATACCTTTAAACAACAGCACCCTAATTTTGATGAACTAGCG
AAACTTTATGAGAAAGACGTAGTAAAACACGTCACCCCTTATTCTAATCGCATGACAGAAGCGATCATAAGCCGTTTGAG
CGATCAAGGCTATAATTTAGTGATTGAAGGTACAGGACGAACAACAGACGTTCCTATTCAAACCGCAACAATGCTTCAAG
CCAAAGGTTATGAAACAAAAATGTATGTTATGGCAGTACCTAAAATCAACTCATATTTAGGAACAATTGAACGATATGAA
ACTATGTATGCAGATGATCCAATGACAGCCAGGGCAACACCAAAACAAGCGCATGATATTGTTGTCAAAAACTTACCGAC
CAATTTAGAAACCCTTCATAAAACGGGCTTATTTAGCGATATAAGGCTTTACAATAGAGAAGGAGTGAAACTCTATTCAA
GATTAGAAACGCCTTCTATTAGTCCGAAAGAGACCTTAGAAAGAGAATTAAATCGTAAAGTATCAGGGAAAGAAATTCAA
CCGACTTTGGAGAGAATAGAGCAAAAAATGCTTCAAAATCAACACCAAGAAACCCCTGAATTTAAAGCAATTCAACAAAA
AATGGAAAGCTTGCAGCCACCTACACCACCAATACCCAAAACACCTAAACTTCCAGGACTTTAA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9365.77 Da        Isoelectric Point: 4.3588

>AT230436 WP_013087943.1 NZ_CP090317:1289-1552 [Xylella fastidiosa subsp. morus]
MHTTNLRKVGGSIMLAVPPAFLDQLHLEVGATVGLAVTDGRLVIEPVLHPQYTLDQLLAEAEASGAYPLPPEEREWVDAP
AVGRELI

Download         Length: 264 bp

>AT230436 NZ_CP124898:c1678161-1677889 [Enterococcus faecalis]
ATGGCAGTTACATATGAAAAAACATTTGAAATTGAAATCATTAATGAGTTATCGGCAAGTGTTTATAATCGAGTATTAAA
CTATGTTTTGAACCATGAATTAAATAAAAATGACTCTCAATTATTGGAAGTCAATTTATTAAACCAATTAAAGCTTGCAA
AACGTGTAAATCTTTTTGATTATTCTTTAGAAGAATTACAAGCCGTTCATGAGTATTGGCGGTCAATGAATCGTTACTCA
AAACAAGTTTTGAATAAAGAGAAAGTGGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A060HFN7

Antitoxin

Source ID Structure
AlphaFold DB A0A060H856

References