Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 1928666..1929225 Replicon chromosome
Accession NC_004603
Organism Vibrio parahaemolyticus RIMD 2210633

Toxin (Protein)


Gene name relE Uniprot ID Q87NN8
Locus tag VP_RS08855 Protein ID WP_005483280.1
Coordinates 1928947..1929225 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q87NN9
Locus tag VP_RS08850 Protein ID WP_005483268.1
Coordinates 1928666..1928950 (+) Length 95 a.a.

Genomic Context

VP_RS08850VP_RS08855VP_RS08795VP_RS08800VP_RS08805VP_RS08810VP_RS08815VP_RS08820VP_RS23585VP_RS08830VP_RS23705VP_RS08840VP_RS08845VP_RS08860VP_RS08865VP_RS08870VP_RS08875VP_RS08880VP_RS08885VP_RS08890VP_RS08895VP_RS08900VP_RS08905VP_RS08910VP_RS08915
Location: 1928666..1928950 (285 bp)
Type: Antitoxin
Protein ID: WP_005483268.1
Location: 1928947..1929225 (279 bp)
Type: Toxin
Protein ID: WP_005483280.1
Location: 1923710..1924879 (1170 bp)
Type: Others
Protein ID: WP_005483289.1
Location: 1924843..1924935 (93 bp)
Type: Others
Protein ID: WP_072833197.1
Location: 1924950..1925483 (534 bp)
Type: Others
Protein ID: WP_005483198.1
Location: 1925581..1925673 (93 bp)
Type: Others
Protein ID: WP_005464677.1
Location: 1925696..1926466 (771 bp)
Type: Others
Protein ID: WP_005464405.1
Location: 1926537..1927358 (822 bp)
Type: Others
Protein ID: WP_005464673.1
Location: 1927333..1927473 (141 bp)
Type: Others
Protein ID: WP_162828790.1
Location: 1927502..1928044 (543 bp)
Type: Others
Protein ID: WP_005464345.1
Location: 1928077..1928166 (90 bp)
Type: Others
Protein ID: WP_072833190.1
Location: 1928198..1928470 (273 bp)
Type: Others
Protein ID: WP_005462157.1
Location: 1928497..1928664 (168 bp)
Type: Others
Protein ID: WP_078532952.1
Location: 1929254..1929364 (111 bp)
Type: Others
Protein ID: WP_082798391.1
Location: 1929372..1929656 (285 bp)
Type: Others
Protein ID: WP_005483310.1
Location: 1929701..1929823 (123 bp)
Type: Others
Protein ID: WP_078511351.1
Location: 1929820..1930296 (477 bp)
Type: Others
Protein ID: WP_005483302.1
Location: 1930324..1930425 (102 bp)
Type: Others
Protein ID: WP_011105959.1
Location: 1930441..1930726 (286 bp)
Type: Others
Protein ID: Protein_1729
Location: 1930888..1931355 (468 bp)
Type: Others
Protein ID: WP_005464650.1
Location: 1931456..1931533 (78 bp)
Type: Others
Protein ID: WP_072833152.1
Location: 1931562..1931936 (375 bp)
Type: Others
Protein ID: WP_005483170.1
Location: 1932074..1932583 (510 bp)
Type: Others
Protein ID: WP_005483274.1
Location: 1933192..1933284 (93 bp)
Type: Others
Protein ID: WP_011105963.1
Location: 1933312..1933824 (513 bp)
Type: Others
Protein ID: WP_024699234.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
VP_RS08795 (VP1823)1923710..1924879-1170WP_005483289.1hypothetical protein-
VP_RS088001924843..1924935-93WP_072833197.1DUF3265 domain-containing protein-
VP_RS08805 (VP1824)1924950..1925483-534WP_005483198.1hypothetical protein-
VP_RS088101925581..1925673-93WP_005464677.1DUF3265 domain-containing protein-
VP_RS08815 (VP1825)1925696..1926466-771WP_005464405.1CBS domain-containing protein-
VP_RS08820 (VP1826)1926537..1927358-822WP_005464673.1DUF1669 domain-containing protein-
VP_RS235851927333..1927473-141WP_162828790.1hypothetical protein-
VP_RS08830 (VP1827)1927502..1928044-543WP_005464345.1GNAT family N-acetyltransferase-
VP_RS237051928077..1928166-90WP_072833190.1DUF3265 domain-containing protein-
VP_RS08840 (VP1828)1928198..1928470-273WP_005462157.1nicotinamide mononucleotide transporter-
VP_RS088451928497..1928664-168WP_078532952.1DUF3265 domain-containing protein-
VP_RS08850 (VP1829)1928666..1928950+285WP_005483268.1type II toxin-antitoxin system RelB/DinJ family antitoxinAntitoxin
VP_RS08855 (VP1830)1928947..1929225+279WP_005483280.1type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE familyToxin
VP_RS088601929254..1929364-111WP_082798391.1DUF3265 domain-containing protein-
VP_RS08865 (VP1831)1929372..1929656-285WP_005483310.1nucleotide pyrophosphohydrolase-
VP_RS088701929701..1929823-123WP_078511351.1DUF3265 domain-containing protein-
VP_RS08875 (VP1832)1929820..1930296-477WP_005483302.1GNAT family N-acetyltransferase-
VP_RS08880 (VP1833)1930324..1930425-102WP_011105959.1DUF3265 domain-containing protein-
VP_RS08885 (VP1834)1930441..1930726-286Protein_1729nucleotide pyrophosphohydrolase-
VP_RS088901930888..1931355-468WP_005464650.1cold shock domain-containing protein-
VP_RS088951931456..1931533-78WP_072833152.1DUF3265 domain-containing protein-
VP_RS08900 (VP1835)1931562..1931936-375WP_005483170.1hypothetical protein-
VP_RS089051932074..1932583-510WP_005483274.1ClbS/DfsB family four-helix bundle protein-
VP_RS08910 (VP1838)1933192..1933284-93WP_011105963.1DUF3265 domain-containing protein-
VP_RS08915 (VP1839)1933312..1933824-513WP_024699234.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
insideIntegron--1901751..194924347492


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-70)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10937.66 Da        Isoelectric Point: 4.2397

>T20885 WP_005483280.1 NC_004603:1928947-1929225 [Vibrio parahaemolyticus RIMD 2210633]
MILWEEESLNDREKIFEFLYDFNPDAAEKTDNLIEANVENLLEQLLMGVQRDGVRGRLLIIPEISMIVSYWIEGDIIRIM
RVLHQKQKFPMD

Download         Length: 279 bp

>T20885 NC_004603:1928947-1929225 [Vibrio parahaemolyticus RIMD 2210633]
ATGATTTTATGGGAAGAAGAGTCACTTAATGATCGTGAAAAGATCTTTGAGTTTCTCTATGACTTTAACCCTGATGCGGC
AGAAAAAACTGACAACCTCATTGAAGCAAACGTAGAAAACTTGCTAGAGCAGCTTCTTATGGGTGTACAGCGAGACGGTG
TTCGTGGGCGATTACTTATAATTCCTGAGATTTCGATGATCGTCTCCTATTGGATCGAAGGCGACATTATCCGAATCATG
CGCGTACTCCACCAGAAACAAAAATTTCCTATGGATTGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 11027.32 Da        Isoelectric Point: 8.0517

>AT20885 WP_005483268.1 NC_004603:1928666-1928950 [Vibrio parahaemolyticus RIMD 2210633]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKSLSHDAWLTEQVNLAFEKFDSGKSVFVEHQTAKSQ
MEERKARIRNRGKQ

Download         Length: 285 bp

>AT20885 NC_004603:1928666-1928950 [Vibrio parahaemolyticus RIMD 2210633]
ATGGACACTAGAATTCAATTTCGTGTTGATGAAGAAACAAAACGCCTAGCTCAACAAATGGCTGAGAGCCAAGGTCGCAC
ACTAAGTGATGCTTGCCGTGAACTTACTGAGCAACTCGCTGAACAACAAAGAAAATCATTATCTCACGATGCGTGGTTAA
CTGAACAAGTAAACCTAGCATTTGAGAAGTTTGACTCAGGAAAATCCGTTTTCGTTGAGCACCAAACTGCTAAATCTCAA
ATGGAAGAACGCAAAGCCAGAATCCGTAATCGAGGTAAGCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBQ87NN8

Antitoxin

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Source
ID
Structure
AlphaFold DBQ87NN9

References