Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 1928666..1929225 Replicon chromosome
Accession NC_004603
Organism Vibrio parahaemolyticus RIMD 2210633

Toxin (Protein)


Gene name relE Uniprot ID Q87NN8
Locus tag VP_RS08855 Protein ID WP_005483280.1
Coordinates 1928947..1929225 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q87NN9
Locus tag VP_RS08850 Protein ID WP_005483268.1
Coordinates 1928666..1928950 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
VP_RS08795 (VP1823) 1923710..1924879 - 1170 WP_005483289.1 hypothetical protein -
VP_RS08800 1924843..1924935 - 93 WP_072833197.1 DUF3265 domain-containing protein -
VP_RS08805 (VP1824) 1924950..1925483 - 534 WP_005483198.1 hypothetical protein -
VP_RS08810 1925581..1925673 - 93 WP_005464677.1 DUF3265 domain-containing protein -
VP_RS08815 (VP1825) 1925696..1926466 - 771 WP_005464405.1 CBS domain-containing protein -
VP_RS08820 (VP1826) 1926537..1927358 - 822 WP_005464673.1 DUF1669 domain-containing protein -
VP_RS23585 1927333..1927473 - 141 WP_162828790.1 hypothetical protein -
VP_RS08830 (VP1827) 1927502..1928044 - 543 WP_005464345.1 GNAT family N-acetyltransferase -
VP_RS23705 1928077..1928166 - 90 WP_072833190.1 DUF3265 domain-containing protein -
VP_RS08840 (VP1828) 1928198..1928470 - 273 WP_005462157.1 nicotinamide mononucleotide transporter -
VP_RS08845 1928497..1928664 - 168 WP_078532952.1 DUF3265 domain-containing protein -
VP_RS08850 (VP1829) 1928666..1928950 + 285 WP_005483268.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
VP_RS08855 (VP1830) 1928947..1929225 + 279 WP_005483280.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
VP_RS08860 1929254..1929364 - 111 WP_082798391.1 DUF3265 domain-containing protein -
VP_RS08865 (VP1831) 1929372..1929656 - 285 WP_005483310.1 nucleotide pyrophosphohydrolase -
VP_RS08870 1929701..1929823 - 123 WP_078511351.1 DUF3265 domain-containing protein -
VP_RS08875 (VP1832) 1929820..1930296 - 477 WP_005483302.1 GNAT family N-acetyltransferase -
VP_RS08880 (VP1833) 1930324..1930425 - 102 WP_011105959.1 DUF3265 domain-containing protein -
VP_RS08885 (VP1834) 1930441..1930726 - 286 Protein_1729 nucleotide pyrophosphohydrolase -
VP_RS08890 1930888..1931355 - 468 WP_005464650.1 cold shock domain-containing protein -
VP_RS08895 1931456..1931533 - 78 WP_072833152.1 DUF3265 domain-containing protein -
VP_RS08900 (VP1835) 1931562..1931936 - 375 WP_005483170.1 hypothetical protein -
VP_RS08905 1932074..1932583 - 510 WP_005483274.1 ClbS/DfsB family four-helix bundle protein -
VP_RS08910 (VP1838) 1933192..1933284 - 93 WP_011105963.1 DUF3265 domain-containing protein -
VP_RS08915 (VP1839) 1933312..1933824 - 513 WP_024699234.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Integron - - 1901751..1949243 47492


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-70)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10937.66 Da        Isoelectric Point: 4.2397

>T20885 WP_005483280.1 NC_004603:1928947-1929225 [Vibrio parahaemolyticus RIMD 2210633]
MILWEEESLNDREKIFEFLYDFNPDAAEKTDNLIEANVENLLEQLLMGVQRDGVRGRLLIIPEISMIVSYWIEGDIIRIM
RVLHQKQKFPMD

Download         Length: 279 bp

>T20885 NC_004603:1928947-1929225 [Vibrio parahaemolyticus RIMD 2210633]
ATGATTTTATGGGAAGAAGAGTCACTTAATGATCGTGAAAAGATCTTTGAGTTTCTCTATGACTTTAACCCTGATGCGGC
AGAAAAAACTGACAACCTCATTGAAGCAAACGTAGAAAACTTGCTAGAGCAGCTTCTTATGGGTGTACAGCGAGACGGTG
TTCGTGGGCGATTACTTATAATTCCTGAGATTTCGATGATCGTCTCCTATTGGATCGAAGGCGACATTATCCGAATCATG
CGCGTACTCCACCAGAAACAAAAATTTCCTATGGATTGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 11027.32 Da        Isoelectric Point: 8.0517

>AT20885 WP_005483268.1 NC_004603:1928666-1928950 [Vibrio parahaemolyticus RIMD 2210633]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKSLSHDAWLTEQVNLAFEKFDSGKSVFVEHQTAKSQ
MEERKARIRNRGKQ

Download         Length: 285 bp

>AT20885 NC_004603:1928666-1928950 [Vibrio parahaemolyticus RIMD 2210633]
ATGGACACTAGAATTCAATTTCGTGTTGATGAAGAAACAAAACGCCTAGCTCAACAAATGGCTGAGAGCCAAGGTCGCAC
ACTAAGTGATGCTTGCCGTGAACTTACTGAGCAACTCGCTGAACAACAAAGAAAATCATTATCTCACGATGCGTGGTTAA
CTGAACAAGTAAACCTAGCATTTGAGAAGTTTGACTCAGGAAAATCCGTTTTCGTTGAGCACCAAACTGCTAAATCTCAA
ATGGAAGAACGCAAAGCCAGAATCCGTAATCGAGGTAAGCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q87NN8

Antitoxin

Source ID Structure
AlphaFold DB Q87NN9

References