74678

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 3228494..3229053 Replicon chromosome
Accession NZ_CP020427
Organism Vibrio parahaemolyticus strain FDAARGOS_191

Toxin (Protein)


Gene name relE Uniprot ID Q87NM5
Locus tag A6J30_RS16010 Protein ID WP_005483176.1
Coordinates 3228494..3228772 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0L8TUJ0
Locus tag A6J30_RS16015 Protein ID WP_005483196.1
Coordinates 3228769..3229053 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A6J30_RS15955 3223961..3224077 + 117 WP_161609357.1 DUF3265 domain-containing protein -
A6J30_RS15960 3224122..3224538 + 417 WP_021451209.1 GNAT family N-acetyltransferase -
A6J30_RS15965 3224525..3224656 + 132 WP_152948689.1 DUF3265 domain-containing protein -
A6J30_RS15970 3224793..3225032 + 240 WP_005483258.1 hypothetical protein -
A6J30_RS15975 3225171..3225443 + 273 WP_029853404.1 hypothetical protein -
A6J30_RS15980 3225590..3226264 + 675 WP_005483286.1 hypothetical protein -
A6J30_RS15985 3226476..3226874 + 399 WP_005483218.1 DUF1311 domain-containing protein -
A6J30_RS15995 3227008..3227682 + 675 WP_005483207.1 hypothetical protein -
A6J30_RS16000 3227821..3228342 + 522 WP_005483288.1 GNAT family N-acetyltransferase -
A6J30_RS16005 3228349..3228465 + 117 WP_080931826.1 DUF3265 domain-containing protein -
A6J30_RS16010 3228494..3228772 - 279 WP_005483176.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
A6J30_RS16015 3228769..3229053 - 285 WP_005483196.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
A6J30_RS16020 3229130..3229221 + 92 Protein_2821 DUF3265 domain-containing protein -
A6J30_RS16025 3229250..3229888 + 639 WP_005483241.1 hypothetical protein -
A6J30_RS16030 3229872..3229994 + 123 WP_021451208.1 DUF3265 domain-containing protein -
A6J30_RS16035 3230022..3230603 + 582 WP_005483293.1 hypothetical protein -
A6J30_RS16040 3230745..3231257 + 513 WP_024699234.1 hypothetical protein -
A6J30_RS16045 3231285..3231377 + 93 WP_011105963.1 DUF3265 domain-containing protein -
A6J30_RS16060 3231986..3232495 + 510 WP_005483274.1 ClbS/DfsB family four-helix bundle protein -
A6J30_RS16070 3232633..3233007 + 375 WP_005483170.1 hypothetical protein -
A6J30_RS16075 3233036..3233113 + 78 WP_072833152.1 DUF3265 domain-containing protein -
A6J30_RS16080 3233214..3233681 + 468 WP_005464650.1 cold shock domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3214802..3265461 50659
inside Integron - - 3215326..3262818 47492


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(1-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-45)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10906.55 Da        Isoelectric Point: 4.3430

>T74678 WP_005483176.1 NZ_CP020427:c3228772-3228494 [Vibrio parahaemolyticus]
MILWEEESLNDREEIFEFLYDFNPDAAEKTDNLIEAKVENLLKQPLMGVQRDGIRGRLLIIPEISMIVSYWVEGDIIRVM
RVQHQKQKFPTD

Download         Length: 279 bp

>T74678 NZ_CP020427:c3228772-3228494 [Vibrio parahaemolyticus]
ATGATTTTATGGGAAGAAGAGTCACTTAATGATCGTGAAGAGATCTTTGAGTTTCTCTATGACTTCAACCCTGATGCTGC
AGAAAAAACTGACAACCTCATTGAAGCAAAAGTAGAAAACTTGCTTAAACAACCTTTAATGGGTGTGCAACGAGATGGCA
TCCGCGGACGATTACTCATCATTCCTGAGATTTCGATGATTGTATCTTACTGGGTTGAGGGCGATATCATCCGAGTTATG
CGTGTACAACACCAGAAACAAAAATTCCCTACGGATTGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 11083.43 Da        Isoelectric Point: 9.2167

>AT74678 WP_005483196.1 NZ_CP020427:c3229053-3228769 [Vibrio parahaemolyticus]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKTLSHDAWLTEQVNLAFEKFDSGKSVFLEHQTAKSR
MEERKARIRNRGKQ

Download         Length: 285 bp

>AT74678 NZ_CP020427:c3229053-3228769 [Vibrio parahaemolyticus]
ATGGACACTAGAATTCAATTTCGTGTTGATGAAGAAACAAAACGCCTAGCTCAACAAATGGCTGAGAGCCAAGGTCGCAC
TCTGAGTGACGCATGTCGTGAACTTACTGAGCAACTCGCTGAACAACAAAGAAAAACATTATCTCACGATGCATGGCTAA
CTGAACAAGTAAACCTAGCATTTGAGAAGTTTGACTCAGGAAAATCTGTTTTCCTTGAGCACCAAACGGCTAAGTCTCGA
ATGGAAGAGCGCAAAGCCAGAATCCGTAATCGAGGTAAGCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q87NM5

Antitoxin

Source ID Structure
AlphaFold DB A0A0L8TUJ0

References