Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 1935516..1936075 Replicon chromosome
Accession NC_004603
Organism Vibrio parahaemolyticus RIMD 2210633

Toxin (Protein)


Gene name relE Uniprot ID Q87NM5
Locus tag VP_RS08945 Protein ID WP_005483176.1
Coordinates 1935797..1936075 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0L8TUJ0
Locus tag VP_RS08940 Protein ID WP_005483196.1
Coordinates 1935516..1935800 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
VP_RS08890 1930888..1931355 - 468 WP_005464650.1 cold shock domain-containing protein -
VP_RS08895 1931456..1931533 - 78 WP_072833152.1 DUF3265 domain-containing protein -
VP_RS08900 (VP1835) 1931562..1931936 - 375 WP_005483170.1 hypothetical protein -
VP_RS08905 1932074..1932583 - 510 WP_005483274.1 ClbS/DfsB family four-helix bundle protein -
VP_RS08910 (VP1838) 1933192..1933284 - 93 WP_011105963.1 DUF3265 domain-containing protein -
VP_RS08915 (VP1839) 1933312..1933824 - 513 WP_024699234.1 hypothetical protein -
VP_RS08920 (VP1840) 1933966..1934547 - 582 WP_005483293.1 hypothetical protein -
VP_RS08925 1934575..1934697 - 123 WP_021451208.1 DUF3265 domain-containing protein -
VP_RS08930 (VP1841) 1934681..1935319 - 639 WP_005483241.1 hypothetical protein -
VP_RS08935 1935348..1935439 - 92 Protein_1739 DUF3265 domain-containing protein -
VP_RS08940 (VP1842) 1935516..1935800 + 285 WP_005483196.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
VP_RS08945 (VP1843) 1935797..1936075 + 279 WP_005483176.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
VP_RS08950 1936104..1936220 - 117 WP_080931826.1 DUF3265 domain-containing protein -
VP_RS08955 (VP1844) 1936227..1936748 - 522 WP_005483288.1 GNAT family N-acetyltransferase -
VP_RS08960 (VP1845) 1936887..1937561 - 675 WP_005483207.1 hypothetical protein -
VP_RS08965 (VP1847) 1937695..1938093 - 399 WP_005483218.1 DUF1311 domain-containing protein -
VP_RS08970 (VP1848) 1938305..1938979 - 675 WP_005483286.1 hypothetical protein -
VP_RS08975 1939126..1939398 - 273 WP_029853404.1 hypothetical protein -
VP_RS08980 (VP1849) 1939537..1939776 - 240 WP_005483258.1 hypothetical protein -
VP_RS08985 1939913..1940002 - 90 WP_072833189.1 DUF3265 domain-containing protein -
VP_RS08990 (VP1850) 1940031..1940447 - 417 WP_021451209.1 GNAT family N-acetyltransferase -
VP_RS08995 1940492..1940584 - 93 WP_072833185.1 DUF3265 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Integron - - 1901751..1949243 47492


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(1-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-45)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10906.55 Da        Isoelectric Point: 4.3430

>T20886 WP_005483176.1 NC_004603:1935797-1936075 [Vibrio parahaemolyticus RIMD 2210633]
MILWEEESLNDREEIFEFLYDFNPDAAEKTDNLIEAKVENLLKQPLMGVQRDGIRGRLLIIPEISMIVSYWVEGDIIRVM
RVQHQKQKFPTD

Download         Length: 279 bp

>T20886 NC_004603:1935797-1936075 [Vibrio parahaemolyticus RIMD 2210633]
ATGATTTTATGGGAAGAAGAGTCACTTAATGATCGTGAAGAGATCTTTGAGTTTCTCTATGACTTCAACCCTGATGCTGC
AGAAAAAACTGACAACCTCATTGAAGCAAAAGTAGAAAACTTGCTTAAACAACCTTTAATGGGTGTGCAACGAGATGGCA
TCCGCGGACGATTACTCATCATTCCTGAGATTTCGATGATTGTATCTTACTGGGTTGAGGGCGATATCATCCGAGTTATG
CGTGTACAACACCAGAAACAAAAATTCCCTACGGATTGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 11083.43 Da        Isoelectric Point: 9.2167

>AT20886 WP_005483196.1 NC_004603:1935516-1935800 [Vibrio parahaemolyticus RIMD 2210633]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKTLSHDAWLTEQVNLAFEKFDSGKSVFLEHQTAKSR
MEERKARIRNRGKQ

Download         Length: 285 bp

>AT20886 NC_004603:1935516-1935800 [Vibrio parahaemolyticus RIMD 2210633]
ATGGACACTAGAATTCAATTTCGTGTTGATGAAGAAACAAAACGCCTAGCTCAACAAATGGCTGAGAGCCAAGGTCGCAC
TCTGAGTGACGCATGTCGTGAACTTACTGAGCAACTCGCTGAACAACAAAGAAAAACATTATCTCACGATGCATGGCTAA
CTGAACAAGTAAACCTAGCATTTGAGAAGTTTGACTCAGGAAAATCTGTTTTCCTTGAGCACCAAACGGCTAAGTCTCGA
ATGGAAGAGCGCAAAGCCAGAATCCGTAATCGAGGTAAGCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q87NM5

Antitoxin

Source ID Structure
AlphaFold DB A0A0L8TUJ0

References