Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 1935516..1936075 Replicon chromosome
Accession NC_004603
Organism Vibrio parahaemolyticus RIMD 2210633

Toxin (Protein)


Gene name relE Uniprot ID Q87NM5
Locus tag VP_RS08945 Protein ID WP_005483176.1
Coordinates 1935797..1936075 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0L8TUJ0
Locus tag VP_RS08940 Protein ID WP_005483196.1
Coordinates 1935516..1935800 (+) Length 95 a.a.

Genomic Context

VP_RS08940VP_RS08945VP_RS08890VP_RS08895VP_RS08900VP_RS08905VP_RS08910VP_RS08915VP_RS08920VP_RS08925VP_RS08930VP_RS08935VP_RS08950VP_RS08955VP_RS08960VP_RS08965VP_RS08970VP_RS08975VP_RS08980VP_RS08985VP_RS08990VP_RS08995
Location: 1935516..1935800 (285 bp)
Type: Antitoxin
Protein ID: WP_005483196.1
Location: 1935797..1936075 (279 bp)
Type: Toxin
Protein ID: WP_005483176.1
Location: 1930888..1931355 (468 bp)
Type: Others
Protein ID: WP_005464650.1
Location: 1931456..1931533 (78 bp)
Type: Others
Protein ID: WP_072833152.1
Location: 1931562..1931936 (375 bp)
Type: Others
Protein ID: WP_005483170.1
Location: 1932074..1932583 (510 bp)
Type: Others
Protein ID: WP_005483274.1
Location: 1933192..1933284 (93 bp)
Type: Others
Protein ID: WP_011105963.1
Location: 1933312..1933824 (513 bp)
Type: Others
Protein ID: WP_024699234.1
Location: 1933966..1934547 (582 bp)
Type: Others
Protein ID: WP_005483293.1
Location: 1934575..1934697 (123 bp)
Type: Others
Protein ID: WP_021451208.1
Location: 1934681..1935319 (639 bp)
Type: Others
Protein ID: WP_005483241.1
Location: 1935348..1935439 (92 bp)
Type: Others
Protein ID: Protein_1739
Location: 1936104..1936220 (117 bp)
Type: Others
Protein ID: WP_080931826.1
Location: 1936227..1936748 (522 bp)
Type: Others
Protein ID: WP_005483288.1
Location: 1936887..1937561 (675 bp)
Type: Others
Protein ID: WP_005483207.1
Location: 1937695..1938093 (399 bp)
Type: Others
Protein ID: WP_005483218.1
Location: 1938305..1938979 (675 bp)
Type: Others
Protein ID: WP_005483286.1
Location: 1939126..1939398 (273 bp)
Type: Others
Protein ID: WP_029853404.1
Location: 1939537..1939776 (240 bp)
Type: Others
Protein ID: WP_005483258.1
Location: 1939913..1940002 (90 bp)
Type: Others
Protein ID: WP_072833189.1
Location: 1940031..1940447 (417 bp)
Type: Others
Protein ID: WP_021451209.1
Location: 1940492..1940584 (93 bp)
Type: Others
Protein ID: WP_072833185.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
VP_RS088901930888..1931355-468WP_005464650.1cold shock domain-containing protein-
VP_RS088951931456..1931533-78WP_072833152.1DUF3265 domain-containing protein-
VP_RS08900 (VP1835)1931562..1931936-375WP_005483170.1hypothetical protein-
VP_RS089051932074..1932583-510WP_005483274.1ClbS/DfsB family four-helix bundle protein-
VP_RS08910 (VP1838)1933192..1933284-93WP_011105963.1DUF3265 domain-containing protein-
VP_RS08915 (VP1839)1933312..1933824-513WP_024699234.1hypothetical protein-
VP_RS08920 (VP1840)1933966..1934547-582WP_005483293.1hypothetical protein-
VP_RS089251934575..1934697-123WP_021451208.1DUF3265 domain-containing protein-
VP_RS08930 (VP1841)1934681..1935319-639WP_005483241.1hypothetical protein-
VP_RS089351935348..1935439-92Protein_1739DUF3265 domain-containing protein-
VP_RS08940 (VP1842)1935516..1935800+285WP_005483196.1type II toxin-antitoxin system RelB/DinJ family antitoxinAntitoxin
VP_RS08945 (VP1843)1935797..1936075+279WP_005483176.1type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE familyToxin
VP_RS089501936104..1936220-117WP_080931826.1DUF3265 domain-containing protein-
VP_RS08955 (VP1844)1936227..1936748-522WP_005483288.1GNAT family N-acetyltransferase-
VP_RS08960 (VP1845)1936887..1937561-675WP_005483207.1hypothetical protein-
VP_RS08965 (VP1847)1937695..1938093-399WP_005483218.1DUF1311 domain-containing protein-
VP_RS08970 (VP1848)1938305..1938979-675WP_005483286.1hypothetical protein-
VP_RS089751939126..1939398-273WP_029853404.1hypothetical protein-
VP_RS08980 (VP1849)1939537..1939776-240WP_005483258.1hypothetical protein-
VP_RS089851939913..1940002-90WP_072833189.1DUF3265 domain-containing protein-
VP_RS08990 (VP1850)1940031..1940447-417WP_021451209.1GNAT family N-acetyltransferase-
VP_RS089951940492..1940584-93WP_072833185.1DUF3265 domain-containing protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
insideIntegron--1901751..194924347492


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(1-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-45)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10906.55 Da        Isoelectric Point: 4.3430

>T20886 WP_005483176.1 NC_004603:1935797-1936075 [Vibrio parahaemolyticus RIMD 2210633]
MILWEEESLNDREEIFEFLYDFNPDAAEKTDNLIEAKVENLLKQPLMGVQRDGIRGRLLIIPEISMIVSYWVEGDIIRVM
RVQHQKQKFPTD

Download         Length: 279 bp

>T20886 NC_004603:1935797-1936075 [Vibrio parahaemolyticus RIMD 2210633]
ATGATTTTATGGGAAGAAGAGTCACTTAATGATCGTGAAGAGATCTTTGAGTTTCTCTATGACTTCAACCCTGATGCTGC
AGAAAAAACTGACAACCTCATTGAAGCAAAAGTAGAAAACTTGCTTAAACAACCTTTAATGGGTGTGCAACGAGATGGCA
TCCGCGGACGATTACTCATCATTCCTGAGATTTCGATGATTGTATCTTACTGGGTTGAGGGCGATATCATCCGAGTTATG
CGTGTACAACACCAGAAACAAAAATTCCCTACGGATTGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 11083.43 Da        Isoelectric Point: 9.2167

>AT20886 WP_005483196.1 NC_004603:1935516-1935800 [Vibrio parahaemolyticus RIMD 2210633]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKTLSHDAWLTEQVNLAFEKFDSGKSVFLEHQTAKSR
MEERKARIRNRGKQ

Download         Length: 285 bp

>AT20886 NC_004603:1935516-1935800 [Vibrio parahaemolyticus RIMD 2210633]
ATGGACACTAGAATTCAATTTCGTGTTGATGAAGAAACAAAACGCCTAGCTCAACAAATGGCTGAGAGCCAAGGTCGCAC
TCTGAGTGACGCATGTCGTGAACTTACTGAGCAACTCGCTGAACAACAAAGAAAAACATTATCTCACGATGCATGGCTAA
CTGAACAAGTAAACCTAGCATTTGAGAAGTTTGACTCAGGAAAATCTGTTTTCCTTGAGCACCAAACGGCTAAGTCTCGA
ATGGAAGAGCGCAAAGCCAGAATCCGTAATCGAGGTAAGCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBQ87NM5

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A0L8TUJ0

References