Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-yefM/YoeB-RelB
Location 1922975..1923491 Replicon chromosome
Accession NC_004603
Organism Vibrio parahaemolyticus RIMD 2210633

Toxin (Protein)


Gene name relB Uniprot ID U2ZZV8
Locus tag VP_RS08780 Protein ID WP_005464459.1
Coordinates 1922975..1923244 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A7W4CB60
Locus tag VP_RS08785 Protein ID WP_005483180.1
Coordinates 1923237..1923491 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
VP_RS08725 (VP1813) 1918881..1919270 - 390 WP_005490691.1 hypothetical protein -
VP_RS08730 1919308..1919400 - 93 WP_072833112.1 DUF3265 domain-containing protein -
VP_RS08735 (VP1814) 1919390..1919866 - 477 WP_017449567.1 hypothetical protein -
VP_RS08740 1919988..1920119 - 132 WP_078532947.1 DUF3265 domain-containing protein -
VP_RS08745 1920199..1920405 - 207 WP_005462168.1 hypothetical protein -
VP_RS08750 1920608..1920700 - 93 WP_017045846.1 DUF3265 domain-containing protein -
VP_RS08755 (VP1816) 1920735..1921136 - 402 WP_005483261.1 HIT family protein -
VP_RS08760 1921169..1921285 - 117 WP_161609362.1 DUF3265 domain-containing protein -
VP_RS08765 (VP1817) 1921289..1921735 - 447 WP_024699215.1 hypothetical protein -
VP_RS08770 1922313..1922402 - 90 WP_072833196.1 DUF3265 domain-containing protein -
VP_RS08775 (VP1819) 1922430..1922810 - 381 WP_005467118.1 energy transducer TonB -
VP_RS08780 (VP1820) 1922975..1923244 - 270 WP_005464459.1 Txe/YoeB family addiction module toxin Toxin
VP_RS08785 (VP1821) 1923237..1923491 - 255 WP_005483180.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
VP_RS08790 (VP1822) 1923594..1923686 - 93 WP_011105955.1 DUF3265 domain-containing protein -
VP_RS08795 (VP1823) 1923710..1924879 - 1170 WP_005483289.1 hypothetical protein -
VP_RS08800 1924843..1924935 - 93 WP_072833197.1 DUF3265 domain-containing protein -
VP_RS08805 (VP1824) 1924950..1925483 - 534 WP_005483198.1 hypothetical protein -
VP_RS08810 1925581..1925673 - 93 WP_005464677.1 DUF3265 domain-containing protein -
VP_RS08815 (VP1825) 1925696..1926466 - 771 WP_005464405.1 CBS domain-containing protein -
VP_RS08820 (VP1826) 1926537..1927358 - 822 WP_005464673.1 DUF1669 domain-containing protein -
VP_RS23585 1927333..1927473 - 141 WP_162828790.1 hypothetical protein -
VP_RS08830 (VP1827) 1927502..1928044 - 543 WP_005464345.1 GNAT family N-acetyltransferase -
VP_RS23705 1928077..1928166 - 90 WP_072833190.1 DUF3265 domain-containing protein -
VP_RS08840 (VP1828) 1928198..1928470 - 273 WP_005462157.1 nicotinamide mononucleotide transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Integron - - 1901751..1949243 47492


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(10-89)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10614.96 Da        Isoelectric Point: 7.9816

>T20884 WP_005464459.1 NC_004603:c1923244-1922975 [Vibrio parahaemolyticus RIMD 2210633]
MSSSQRLLSWTDDAWDDYLYWQTQDKKTLKRINKLINDVKRSPFEGIGKPEPLKENLSGFWSRRIDDTNRLVYAVDDQAI
TIISCRYHY

Download         Length: 270 bp

>T20884 NC_004603:c1923244-1922975 [Vibrio parahaemolyticus RIMD 2210633]
ATGAGTAGTAGTCAACGTTTATTATCGTGGACTGATGATGCTTGGGATGACTACCTGTATTGGCAAACTCAAGACAAGAA
AACACTCAAGCGCATCAATAAACTCATCAATGATGTTAAGCGCTCTCCATTTGAGGGCATTGGTAAACCAGAGCCGTTAA
AAGAGAACTTATCTGGTTTTTGGTCTCGTCGTATTGATGATACTAATAGGCTTGTTTACGCAGTCGATGATCAAGCGATA
ACGATAATTTCATGTCGTTACCACTACTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9481.66 Da        Isoelectric Point: 5.0623

>AT20884 WP_005483180.1 NC_004603:c1923491-1923237 [Vibrio parahaemolyticus RIMD 2210633]
MRIVSFTEARNGLKAVLDGVVNDADTTVITRRDSEDAVVMSLDYYNSLMETVHLLRSPQNVEHLNRSIAQYRAGKTTARE
LIDE

Download         Length: 255 bp

>AT20884 NC_004603:c1923491-1923237 [Vibrio parahaemolyticus RIMD 2210633]
ATGAGAATCGTATCTTTTACTGAAGCTAGAAATGGTCTCAAAGCTGTTTTAGACGGTGTAGTTAATGATGCTGATACAAC
AGTTATTACACGCCGTGATTCTGAGGATGCAGTGGTTATGTCTTTAGACTACTACAATAGCCTTATGGAGACTGTTCATT
TACTACGCTCTCCTCAAAACGTTGAACACCTAAACCGTTCGATAGCACAGTACCGCGCTGGTAAAACAACAGCACGAGAG
TTAATTGATGAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U2ZZV8

Antitoxin

Source ID Structure
AlphaFold DB A0A7W4CB60

References