110060

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-yefM/YoeB-RelB
Location 1347409..1347925 Replicon chromosome
Accession NZ_CP031781
Organism Vibrio parahaemolyticus strain VPD14

Toxin (Protein)


Gene name relB Uniprot ID U2ZZV8
Locus tag D0853_RS06930 Protein ID WP_005464459.1
Coordinates 1347656..1347925 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A7W4CB60
Locus tag D0853_RS06925 Protein ID WP_005483180.1
Coordinates 1347409..1347663 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D0853_RS06865 1342430..1342702 + 273 WP_005462157.1 nicotinamide mononucleotide transporter -
D0853_RS25835 1342734..1342823 + 90 WP_072833190.1 DUF3265 domain-containing protein -
D0853_RS06875 1342856..1343398 + 543 WP_005464345.1 GNAT family N-acetyltransferase -
D0853_RS25660 1343427..1343567 + 141 WP_162828790.1 hypothetical protein -
D0853_RS06885 1343542..1344363 + 822 WP_005464673.1 DUF1669 domain-containing protein -
D0853_RS06895 1344434..1345204 + 771 WP_005464405.1 CBS domain-containing protein -
D0853_RS06900 1345227..1345319 + 93 WP_005464677.1 DUF3265 domain-containing protein -
D0853_RS06905 1345417..1345950 + 534 WP_005483198.1 hypothetical protein -
D0853_RS06910 1345965..1346057 + 93 WP_072833197.1 DUF3265 domain-containing protein -
D0853_RS06915 1346021..1347190 + 1170 WP_005483289.1 hypothetical protein -
D0853_RS06920 1347214..1347306 + 93 WP_011105955.1 DUF3265 domain-containing protein -
D0853_RS06925 1347409..1347663 + 255 WP_005483180.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
D0853_RS06930 1347656..1347925 + 270 WP_005464459.1 Txe/YoeB family addiction module toxin Toxin
D0853_RS06935 1348090..1348470 + 381 WP_005467118.1 energy transducer TonB -
D0853_RS06940 1348498..1348587 + 90 WP_072833196.1 DUF3265 domain-containing protein -
D0853_RS06955 1349165..1349611 + 447 WP_024699215.1 hypothetical protein -
D0853_RS06960 1349615..1349731 + 117 WP_161609362.1 DUF3265 domain-containing protein -
D0853_RS06965 1349764..1350165 + 402 WP_005483261.1 HIT family protein -
D0853_RS06970 1350200..1350292 + 93 WP_017045846.1 DUF3265 domain-containing protein -
D0853_RS25665 1350495..1350701 + 207 WP_005462168.1 hypothetical protein -
D0853_RS06980 1350781..1350912 + 132 WP_078532947.1 DUF3265 domain-containing protein -
D0853_RS06985 1351034..1351510 + 477 WP_017449567.1 hypothetical protein -
D0853_RS06990 1351500..1351592 + 93 WP_072833112.1 DUF3265 domain-containing protein -
D0853_RS06995 1351630..1352019 + 390 WP_005490691.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1321718..1369149 47431
inside Integron - - 1322242..1369149 46907


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(10-89)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10614.96 Da        Isoelectric Point: 7.9816

>T110060 WP_005464459.1 NZ_CP031781:1347656-1347925 [Vibrio parahaemolyticus]
MSSSQRLLSWTDDAWDDYLYWQTQDKKTLKRINKLINDVKRSPFEGIGKPEPLKENLSGFWSRRIDDTNRLVYAVDDQAI
TIISCRYHY

Download         Length: 270 bp

>T110060 NZ_CP031781:1347656-1347925 [Vibrio parahaemolyticus]
ATGAGTAGTAGTCAACGTTTATTATCGTGGACTGATGATGCTTGGGATGACTACCTGTATTGGCAAACTCAAGACAAGAA
AACACTCAAGCGCATCAATAAACTCATCAATGATGTTAAGCGCTCTCCATTTGAGGGCATTGGTAAACCAGAGCCGTTAA
AAGAGAACTTATCTGGTTTTTGGTCTCGTCGTATTGATGATACTAATAGGCTTGTTTACGCAGTCGATGATCAAGCGATA
ACGATAATTTCATGTCGTTACCACTACTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9481.66 Da        Isoelectric Point: 5.0623

>AT110060 WP_005483180.1 NZ_CP031781:1347409-1347663 [Vibrio parahaemolyticus]
MRIVSFTEARNGLKAVLDGVVNDADTTVITRRDSEDAVVMSLDYYNSLMETVHLLRSPQNVEHLNRSIAQYRAGKTTARE
LIDE

Download         Length: 255 bp

>AT110060 NZ_CP031781:1347409-1347663 [Vibrio parahaemolyticus]
ATGAGAATCGTATCTTTTACTGAAGCTAGAAATGGTCTCAAAGCTGTTTTAGACGGTGTAGTTAATGATGCTGATACAAC
AGTTATTACACGCCGTGATTCTGAGGATGCAGTGGTTATGTCTTTAGACTACTACAATAGCCTTATGGAGACTGTTCATT
TACTACGCTCTCCTCAAAACGTTGAACACCTAAACCGTTCGATAGCACAGTACCGCGCTGGTAAAACAACAGCACGAGAG
TTAATTGATGAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U2ZZV8

Antitoxin

Source ID Structure
AlphaFold DB A0A7W4CB60

References