110058

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 1335957..1336516 Replicon chromosome
Accession NZ_CP031781
Organism Vibrio parahaemolyticus strain VPD14

Toxin (Protein)


Gene name relE Uniprot ID Q87NM5
Locus tag D0853_RS06765 Protein ID WP_005483176.1
Coordinates 1335957..1336235 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0L8TUJ0
Locus tag D0853_RS06770 Protein ID WP_005483196.1
Coordinates 1336232..1336516 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D0853_RS06710 1331448..1331540 + 93 WP_072833185.1 DUF3265 domain-containing protein -
D0853_RS06715 1331585..1332001 + 417 WP_021451209.1 GNAT family N-acetyltransferase -
D0853_RS06720 1332030..1332119 + 90 WP_072833189.1 DUF3265 domain-containing protein -
D0853_RS06725 1332256..1332495 + 240 WP_005483258.1 hypothetical protein -
D0853_RS06730 1332634..1332906 + 273 WP_029853404.1 hypothetical protein -
D0853_RS06735 1333053..1333727 + 675 WP_005483286.1 hypothetical protein -
D0853_RS06740 1333939..1334337 + 399 WP_005483218.1 DUF1311 domain-containing protein -
D0853_RS06750 1334471..1335145 + 675 WP_005483207.1 hypothetical protein -
D0853_RS06755 1335284..1335805 + 522 WP_005483288.1 GNAT family N-acetyltransferase -
D0853_RS06760 1335812..1335928 + 117 WP_080931826.1 DUF3265 domain-containing protein -
D0853_RS06765 1335957..1336235 - 279 WP_005483176.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
D0853_RS06770 1336232..1336516 - 285 WP_005483196.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
D0853_RS06775 1336593..1336684 + 92 Protein_1155 DUF3265 domain-containing protein -
D0853_RS06780 1336713..1337351 + 639 WP_005483241.1 hypothetical protein -
D0853_RS06785 1337335..1337457 + 123 WP_021451208.1 DUF3265 domain-containing protein -
D0853_RS06790 1337485..1338066 + 582 WP_005483293.1 hypothetical protein -
D0853_RS06795 1338208..1338720 + 513 WP_024699234.1 hypothetical protein -
D0853_RS06800 1338748..1338840 + 93 WP_011105963.1 DUF3265 domain-containing protein -
D0853_RS06815 1339449..1339958 + 510 WP_005483274.1 ClbS/DfsB family four-helix bundle protein -
D0853_RS06825 1340096..1340470 + 375 WP_005483170.1 hypothetical protein -
D0853_RS06830 1340499..1340576 + 78 WP_072833152.1 DUF3265 domain-containing protein -
D0853_RS06835 1340604..1341080 + 477 WP_005483302.1 GNAT family N-acetyltransferase -
D0853_RS06840 1341077..1341199 + 123 WP_078511351.1 DUF3265 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1321718..1369149 47431
inside Integron - - 1322242..1369149 46907


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(1-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-45)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10906.55 Da        Isoelectric Point: 4.3430

>T110058 WP_005483176.1 NZ_CP031781:c1336235-1335957 [Vibrio parahaemolyticus]
MILWEEESLNDREEIFEFLYDFNPDAAEKTDNLIEAKVENLLKQPLMGVQRDGIRGRLLIIPEISMIVSYWVEGDIIRVM
RVQHQKQKFPTD

Download         Length: 279 bp

>T110058 NZ_CP031781:c1336235-1335957 [Vibrio parahaemolyticus]
ATGATTTTATGGGAAGAAGAGTCACTTAATGATCGTGAAGAGATCTTTGAGTTTCTCTATGACTTCAACCCTGATGCTGC
AGAAAAAACTGACAACCTCATTGAAGCAAAAGTAGAAAACTTGCTTAAACAACCTTTAATGGGTGTGCAACGAGATGGCA
TCCGCGGACGATTACTCATCATTCCTGAGATTTCGATGATTGTATCTTACTGGGTTGAGGGCGATATCATCCGAGTTATG
CGTGTACAACACCAGAAACAAAAATTCCCTACGGATTGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 11083.43 Da        Isoelectric Point: 9.2167

>AT110058 WP_005483196.1 NZ_CP031781:c1336516-1336232 [Vibrio parahaemolyticus]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKTLSHDAWLTEQVNLAFEKFDSGKSVFLEHQTAKSR
MEERKARIRNRGKQ

Download         Length: 285 bp

>AT110058 NZ_CP031781:c1336516-1336232 [Vibrio parahaemolyticus]
ATGGACACTAGAATTCAATTTCGTGTTGATGAAGAAACAAAACGCCTAGCTCAACAAATGGCTGAGAGCCAAGGTCGCAC
TCTGAGTGACGCATGTCGTGAACTTACTGAGCAACTCGCTGAACAACAAAGAAAAACATTATCTCACGATGCATGGCTAA
CTGAACAAGTAAACCTAGCATTTGAGAAGTTTGACTCAGGAAAATCTGTTTTCCTTGAGCACCAAACGGCTAAGTCTCGA
ATGGAAGAGCGCAAAGCCAGAATCCGTAATCGAGGTAAGCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q87NM5

Antitoxin

Source ID Structure
AlphaFold DB A0A0L8TUJ0

References