Detailed information of TA system TA074680

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-yefM/YoeB-RelB
• Location: 3241078..3241594
• Replicon: chromosome
• Accession: NZ_CP020427
• Organism: Vibrio parahaemolyticus strain FDAARGOS_191

Toxin (Protein)

• Gene name: relB
• Uniprot ID: U2ZZV8
• Locus tag: A6J30_RS16190
• Protein ID: WP_005464459.1
• Coordinates: 3241325..3241594 (+)
• Length: 90 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: A0A7W4CB60
• Locus tag: A6J30_RS16185
• Protein ID: WP_005483180.1
• Coordinates: 3241078..3241332 (+)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A6J30_RS16130	3236099..3236371	+	273	WP_005462157.1	nicotinamide mononucleotide transporter	-
A6J30_RS25810	3236346..3236492	+	147	WP_074190754.1	DUF3265 domain-containing protein	-
A6J30_RS16140	3236525..3237067	+	543	WP_005464345.1	GNAT family N-acetyltransferase	-
A6J30_RS25815	3237096..3237236	+	141	WP_162828790.1	hypothetical protein	-
A6J30_RS16145	3237211..3238032	+	822	WP_005464673.1	DUF1669 domain-containing protein	-
A6J30_RS16155	3238103..3238873	+	771	WP_005464405.1	CBS domain-containing protein	-
A6J30_RS16160	3238860..3238988	+	129	WP_017420780.1	DUF3265 domain-containing protein	-
A6J30_RS16165	3239086..3239619	+	534	WP_005483198.1	hypothetical protein	-
A6J30_RS16170	3239616..3239726	+	111	WP_161609361.1	DUF3265 domain-containing protein	-
A6J30_RS16175	3239690..3240859	+	1170	WP_005483289.1	hypothetical protein	-
A6J30_RS16180	3240865..3240975	+	111	WP_161609363.1	DUF3265 domain-containing protein	-
A6J30_RS16185	3241078..3241332	+	255	WP_005483180.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
A6J30_RS16190	3241325..3241594	+	270	WP_005464459.1	Txe/YoeB family addiction module toxin	Toxin
A6J30_RS16195	3241759..3242139	+	381	WP_005467118.1	energy transducer TonB	-
A6J30_RS16200	3242146..3242256	+	111	WP_080006484.1	DUF3265 domain-containing protein	-
A6J30_RS16215	3242834..3243280	+	447	WP_024699215.1	hypothetical protein	-
A6J30_RS16220	3243284..3243400	+	117	WP_161609362.1	DUF3265 domain-containing protein	-
A6J30_RS16225	3243433..3243834	+	402	WP_005483261.1	HIT family protein	-
A6J30_RS16230	3243848..3243961	+	114	WP_080006403.1	DUF3265 domain-containing protein	-
A6J30_RS25820	3244164..3244370	+	207	WP_005462168.1	hypothetical protein	-
A6J30_RS16240	3244450..3244581	+	132	WP_078532947.1	DUF3265 domain-containing protein	-
A6J30_RS16245	3244703..3245179	+	477	WP_017449567.1	hypothetical protein	-
A6J30_RS16250	3245145..3245261	+	117	WP_078532948.1	DUF3265 domain-containing protein	-
A6J30_RS16255	3245299..3245688	+	390	WP_005490691.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3214802..3265461	50659
	Similar MGE(s) Similar MGE(s) is defined as other TA-related MGE(s) with Mash distance < 0.01 to this MGE. Detail Genome accession Organism MGE type Related TA Coordinates Mash distance View NC_004603 Vibrio parahaemolyticus RIMD 2210633 Integron TA000705, TA020884, TA020885, TA020886 1901751..1949243 0	inside	Integron	-	-	3215326..3262818	47492

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (10-89)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-74)

Sequences

Toxin

Protein

• Length: 90 a.a.
• Molecular weight: 10614.96 Da
• Isoelectric Point: 7.9816

>T74680 WP_005464459.1 NZ_CP020427:3241325-3241594 [Vibrio parahaemolyticus]
MSSSQRLLSWTDDAWDDYLYWQTQDKKTLKRINKLINDVKRSPFEGIGKPEPLKENLSGFWSRRIDDTNRLVYAVDDQAI
TIISCRYHY

Nucleotide

• Length: 270 bp

>T74680 NZ_CP020427:3241325-3241594 [Vibrio parahaemolyticus]
ATGAGTAGTAGTCAACGTTTATTATCGTGGACTGATGATGCTTGGGATGACTACCTGTATTGGCAAACTCAAGACAAGAA
AACACTCAAGCGCATCAATAAACTCATCAATGATGTTAAGCGCTCTCCATTTGAGGGCATTGGTAAACCAGAGCCGTTAA
AAGAGAACTTATCTGGTTTTTGGTCTCGTCGTATTGATGATACTAATAGGCTTGTTTACGCAGTCGATGATCAAGCGATA
ACGATAATTTCATGTCGTTACCACTACTAA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9481.66 Da
• Isoelectric Point: 5.0623

>AT74680 WP_005483180.1 NZ_CP020427:3241078-3241332 [Vibrio parahaemolyticus]
MRIVSFTEARNGLKAVLDGVVNDADTTVITRRDSEDAVVMSLDYYNSLMETVHLLRSPQNVEHLNRSIAQYRAGKTTARE
LIDE

Nucleotide

• Length: 255 bp

>AT74680 NZ_CP020427:3241078-3241332 [Vibrio parahaemolyticus]
ATGAGAATCGTATCTTTTACTGAAGCTAGAAATGGTCTCAAAGCTGTTTTAGACGGTGTAGTTAATGATGCTGATACAAC
AGTTATTACACGCCGTGATTCTGAGGATGCAGTGGTTATGTCTTTAGACTACTACAATAGCCTTATGGAGACTGTTCATT
TACTACGCTCTCCTCAAAACGTTGAACACCTAAACCGTTCGATAGCACAGTACCGCGCTGGTAAAACAACAGCACGAGAG
TTAATTGATGAGTAG

Structures

Toxin

• AlphaFold DB: U2ZZV8

Antitoxin

• AlphaFold DB: A0A7W4CB60