Detailed information of TA system TA110059

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-RelB
• Location: 1341675..1342234
• Replicon: chromosome
• Accession: NZ_CP031781
• Organism: Vibrio parahaemolyticus strain VPD14

Toxin (Protein)

• Gene name: relE
• Uniprot ID: Q87NN8
• Locus tag: D0853_RS06855
• Protein ID: WP_005483280.1
• Coordinates: 1341675..1341953 (-)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: Q87NN9
• Locus tag: D0853_RS06860
• Protein ID: WP_005483268.1
• Coordinates: 1341950..1342234 (-)
• Length: 95 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D0853_RS06780	1336713..1337351	+	639	WP_005483241.1	hypothetical protein	-
D0853_RS06785	1337335..1337457	+	123	WP_021451208.1	DUF3265 domain-containing protein	-
D0853_RS06790	1337485..1338066	+	582	WP_005483293.1	hypothetical protein	-
D0853_RS06795	1338208..1338720	+	513	WP_024699234.1	hypothetical protein	-
D0853_RS06800	1338748..1338840	+	93	WP_011105963.1	DUF3265 domain-containing protein	-
D0853_RS06815	1339449..1339958	+	510	WP_005483274.1	ClbS/DfsB family four-helix bundle protein	-
D0853_RS06825	1340096..1340470	+	375	WP_005483170.1	hypothetical protein	-
D0853_RS06830	1340499..1340576	+	78	WP_072833152.1	DUF3265 domain-containing protein	-
D0853_RS06835	1340604..1341080	+	477	WP_005483302.1	GNAT family N-acetyltransferase	-
D0853_RS06840	1341077..1341199	+	123	WP_078511351.1	DUF3265 domain-containing protein	-
D0853_RS06845	1341244..1341528	+	285	WP_005483310.1	nucleotide pyrophosphohydrolase	-
D0853_RS06850	1341536..1341646	+	111	WP_082798391.1	DUF3265 domain-containing protein	-
D0853_RS06855	1341675..1341953	-	279	WP_005483280.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
D0853_RS06860	1341950..1342234	-	285	WP_005483268.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
D0853_RS25830	1342311..1342403	+	93	WP_072833191.1	DUF3265 domain-containing protein	-
D0853_RS06865	1342430..1342702	+	273	WP_005462157.1	nicotinamide mononucleotide transporter	-
D0853_RS25835	1342734..1342823	+	90	WP_072833190.1	DUF3265 domain-containing protein	-
D0853_RS06875	1342856..1343398	+	543	WP_005464345.1	GNAT family N-acetyltransferase	-
D0853_RS25660	1343427..1343567	+	141	WP_162828790.1	hypothetical protein	-
D0853_RS06885	1343542..1344363	+	822	WP_005464673.1	DUF1669 domain-containing protein	-
D0853_RS06895	1344434..1345204	+	771	WP_005464405.1	CBS domain-containing protein	-
D0853_RS06900	1345227..1345319	+	93	WP_005464677.1	DUF3265 domain-containing protein	-
D0853_RS06905	1345417..1345950	+	534	WP_005483198.1	hypothetical protein	-
D0853_RS06910	1345965..1346057	+	93	WP_072833197.1	DUF3265 domain-containing protein	-
D0853_RS06915	1346021..1347190	+	1170	WP_005483289.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1321718..1369149	47431
	Similar MGE(s) Similar MGE(s) is defined as other TA-related MGE(s) with Mash distance < 0.01 to this MGE. Detail Genome accession Organism MGE type Related TA Coordinates Mash distance View NC_004603 Vibrio parahaemolyticus RIMD 2210633 Integron TA000705, TA020884, TA020885, TA020886 1901751..1949243 0	inside	Integron	-	-	1322242..1369149	46907

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (2-89)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (5-70)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10937.66 Da
• Isoelectric Point: 4.2397

>T110059 WP_005483280.1 NZ_CP031781:c1341953-1341675 [Vibrio parahaemolyticus]
MILWEEESLNDREKIFEFLYDFNPDAAEKTDNLIEANVENLLEQLLMGVQRDGVRGRLLIIPEISMIVSYWIEGDIIRIM
RVLHQKQKFPMD

Nucleotide

• Length: 279 bp

>T110059 NZ_CP031781:c1341953-1341675 [Vibrio parahaemolyticus]
ATGATTTTATGGGAAGAAGAGTCACTTAATGATCGTGAAAAGATCTTTGAGTTTCTCTATGACTTTAACCCTGATGCGGC
AGAAAAAACTGACAACCTCATTGAAGCAAACGTAGAAAACTTGCTAGAGCAGCTTCTTATGGGTGTACAGCGAGACGGTG
TTCGTGGGCGATTACTTATAATTCCTGAGATTTCGATGATCGTCTCCTATTGGATCGAAGGCGACATTATCCGAATCATG
CGCGTACTCCACCAGAAACAAAAATTTCCTATGGATTGA

Antitoxin

Protein

• Length: 95 a.a.
• Molecular weight: 11027.32 Da
• Isoelectric Point: 8.0517

>AT110059 WP_005483268.1 NZ_CP031781:c1342234-1341950 [Vibrio parahaemolyticus]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKSLSHDAWLTEQVNLAFEKFDSGKSVFVEHQTAKSQ
MEERKARIRNRGKQ

Nucleotide

• Length: 285 bp

>AT110059 NZ_CP031781:c1342234-1341950 [Vibrio parahaemolyticus]
ATGGACACTAGAATTCAATTTCGTGTTGATGAAGAAACAAAACGCCTAGCTCAACAAATGGCTGAGAGCCAAGGTCGCAC
ACTAAGTGATGCTTGCCGTGAACTTACTGAGCAACTCGCTGAACAACAAAGAAAATCATTATCTCACGATGCGTGGTTAA
CTGAACAAGTAAACCTAGCATTTGAGAAGTTTGACTCAGGAAAATCCGTTTTCGTTGAGCACCAAACTGCTAAATCTCAA
ATGGAAGAACGCAAAGCCAGAATCCGTAATCGAGGTAAGCAATGA

Structures

Toxin

• AlphaFold DB: Q87NN8

Antitoxin

• AlphaFold DB: Q87NN9