Detailed information of TA system TA074679

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-RelB
• Location: 3235344..3235903
• Replicon: chromosome
• Accession: NZ_CP020427
• Organism: Vibrio parahaemolyticus strain FDAARGOS_191

Toxin (Protein)

• Gene name: relE
• Uniprot ID: Q87NN8
• Locus tag: A6J30_RS16115
• Protein ID: WP_005483280.1
• Coordinates: 3235344..3235622 (-)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: Q87NN9
• Locus tag: A6J30_RS16120
• Protein ID: WP_005483268.1
• Coordinates: 3235619..3235903 (-)
• Length: 95 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A6J30_RS16040	3230745..3231257	+	513	WP_024699234.1	hypothetical protein	-
A6J30_RS16045	3231285..3231377	+	93	WP_011105963.1	DUF3265 domain-containing protein	-
A6J30_RS16060	3231986..3232495	+	510	WP_005483274.1	ClbS/DfsB family four-helix bundle protein	-
A6J30_RS16070	3232633..3233007	+	375	WP_005483170.1	hypothetical protein	-
A6J30_RS16075	3233036..3233113	+	78	WP_072833152.1	DUF3265 domain-containing protein	-
A6J30_RS16080	3233214..3233681	+	468	WP_005464650.1	cold shock domain-containing protein	-
A6J30_RS16085	3233843..3234128	+	286	Protein_2831	nucleotide pyrophosphohydrolase	-
A6J30_RS16090	3234144..3234245	+	102	WP_011105959.1	DUF3265 domain-containing protein	-
A6J30_RS16095	3234273..3234749	+	477	WP_005483302.1	GNAT family N-acetyltransferase	-
A6J30_RS16100	3234746..3234868	+	123	WP_078511351.1	DUF3265 domain-containing protein	-
A6J30_RS16105	3234913..3235197	+	285	WP_005483310.1	nucleotide pyrophosphohydrolase	-
A6J30_RS16110	3235213..3235315	+	103	Protein_2836	DUF3265 domain-containing protein	-
A6J30_RS16115	3235344..3235622	-	279	WP_005483280.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
A6J30_RS16120	3235619..3235903	-	285	WP_005483268.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
A6J30_RS25805	3235905..3236072	+	168	WP_078532952.1	DUF3265 domain-containing protein	-
A6J30_RS16130	3236099..3236371	+	273	WP_005462157.1	nicotinamide mononucleotide transporter	-
A6J30_RS25810	3236346..3236492	+	147	WP_074190754.1	DUF3265 domain-containing protein	-
A6J30_RS16140	3236525..3237067	+	543	WP_005464345.1	GNAT family N-acetyltransferase	-
A6J30_RS25815	3237096..3237236	+	141	WP_162828790.1	hypothetical protein	-
A6J30_RS16145	3237211..3238032	+	822	WP_005464673.1	DUF1669 domain-containing protein	-
A6J30_RS16155	3238103..3238873	+	771	WP_005464405.1	CBS domain-containing protein	-
A6J30_RS16160	3238860..3238988	+	129	WP_017420780.1	DUF3265 domain-containing protein	-
A6J30_RS16165	3239086..3239619	+	534	WP_005483198.1	hypothetical protein	-
A6J30_RS16170	3239616..3239726	+	111	WP_161609361.1	DUF3265 domain-containing protein	-
A6J30_RS16175	3239690..3240859	+	1170	WP_005483289.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3214802..3265461	50659
	Similar MGE(s) Similar MGE(s) is defined as other TA-related MGE(s) with Mash distance < 0.01 to this MGE. Detail Genome accession Organism MGE type Related TA Coordinates Mash distance View NC_004603 Vibrio parahaemolyticus RIMD 2210633 Integron TA000705, TA020884, TA020885, TA020886 1901751..1949243 0	inside	Integron	-	-	3215326..3262818	47492

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (2-89)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (5-70)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10937.66 Da
• Isoelectric Point: 4.2397

>T74679 WP_005483280.1 NZ_CP020427:c3235622-3235344 [Vibrio parahaemolyticus]
MILWEEESLNDREKIFEFLYDFNPDAAEKTDNLIEANVENLLEQLLMGVQRDGVRGRLLIIPEISMIVSYWIEGDIIRIM
RVLHQKQKFPMD

Nucleotide

• Length: 279 bp

>T74679 NZ_CP020427:c3235622-3235344 [Vibrio parahaemolyticus]
ATGATTTTATGGGAAGAAGAGTCACTTAATGATCGTGAAAAGATCTTTGAGTTTCTCTATGACTTTAACCCTGATGCGGC
AGAAAAAACTGACAACCTCATTGAAGCAAACGTAGAAAACTTGCTAGAGCAGCTTCTTATGGGTGTACAGCGAGACGGTG
TTCGTGGGCGATTACTTATAATTCCTGAGATTTCGATGATCGTCTCCTATTGGATCGAAGGCGACATTATCCGAATCATG
CGCGTACTCCACCAGAAACAAAAATTTCCTATGGATTGA

Antitoxin

Protein

• Length: 95 a.a.
• Molecular weight: 11027.32 Da
• Isoelectric Point: 8.0517

>AT74679 WP_005483268.1 NZ_CP020427:c3235903-3235619 [Vibrio parahaemolyticus]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKSLSHDAWLTEQVNLAFEKFDSGKSVFVEHQTAKSQ
MEERKARIRNRGKQ

Nucleotide

• Length: 285 bp

>AT74679 NZ_CP020427:c3235903-3235619 [Vibrio parahaemolyticus]
ATGGACACTAGAATTCAATTTCGTGTTGATGAAGAAACAAAACGCCTAGCTCAACAAATGGCTGAGAGCCAAGGTCGCAC
ACTAAGTGATGCTTGCCGTGAACTTACTGAGCAACTCGCTGAACAACAAAGAAAATCATTATCTCACGATGCGTGGTTAA
CTGAACAAGTAAACCTAGCATTTGAGAAGTTTGACTCAGGAAAATCCGTTTTCGTTGAGCACCAAACTGCTAAATCTCAA
ATGGAAGAACGCAAAGCCAGAATCCGTAATCGAGGTAAGCAATGA

Structures

Toxin

• AlphaFold DB: Q87NN8

Antitoxin

• AlphaFold DB: Q87NN9