20765

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 1986010..1986523 Replicon chromosome
Accession NC_004116
Organism Streptococcus agalactiae 2603V/R

Toxin (Protein)


Gene name yoeB Uniprot ID Q8DX49
Locus tag SAG_RS12575 Protein ID WP_000481712.1
Coordinates 1986010..1986264 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID Q8DX48
Locus tag SAG_RS12580 Protein ID WP_000387490.1
Coordinates 1986257..1986523 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SAG_RS12555 (SAG2004) 1984099..1984275 - 177 Protein_1934 conjugal transfer protein -
SAG_RS12560 (SAG2005) 1984296..1984706 - 411 WP_000390747.1 conjugal transfer protein -
SAG_RS12565 (SAG2006) 1984717..1984983 - 267 WP_001055037.1 hypothetical protein -
SAG_RS12570 (SAG2007) 1985004..1985957 - 954 WP_000565539.1 conjugal transfer protein -
SAG_RS12575 (SAG2008) 1986010..1986264 - 255 WP_000481712.1 Txe/YoeB family addiction module toxin Toxin
SAG_RS12580 (SAG2009) 1986257..1986523 - 267 WP_000387490.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
SAG_RS12585 (SAG2010) 1986668..1987141 - 474 WP_000560386.1 hypothetical protein -
SAG_RS12590 (SAG2011) 1987149..1987631 - 483 WP_000383283.1 antirestriction protein ArdA -
SAG_RS12595 (SAG2012) 1987684..1987956 - 273 WP_000017154.1 hypothetical protein -
SAG_RS12600 (SAG2013) 1988091..1988660 - 570 WP_000010056.1 hypothetical protein -
SAG_RS12605 (SAG2014) 1988663..1990012 - 1350 WP_000491711.1 AAA family ATPase -
SAG_RS12610 (SAG2015) 1990209..1990508 - 300 WP_000737133.1 helix-turn-helix domain-containing protein -
SAG_RS12615 (SAG2016) 1990492..1990869 - 378 WP_000287183.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Integrative and Conjugative Element - - 1962263..2005693 43430
flank IS/Tn - - 1983230..1983619 389


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(4-83)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10445.87 Da        Isoelectric Point: 6.7282

>T20765 WP_000481712.1 NC_004116:c1986264-1986010 [Streptococcus agalactiae 2603V/R]
MFNFTEEAWKDYVSWQQEDKKILKRINRLIEDIKRDPFEGIGKPEPLKYHYSGAWSRRITEEHRLIYMIEDGEIYFLSFR
DHYK

Download         Length: 255 bp

>T20765 NC_004116:c1986264-1986010 [Streptococcus agalactiae 2603V/R]
ATGTTTAATTTTACTGAAGAAGCATGGAAAGATTATGTTTCTTGGCAACAGGAAGATAAAAAAATCTTGAAACGAATTAA
TCGTTTGATAGAAGATATTAAAAGAGACCCATTTGAAGGCATTGGAAAACCAGAACCTTTAAAATACCATTATTCAGGGG
CTTGGTCTCGAAGAATTACAGAAGAACATAGGTTGATTTATATGATAGAAGATGGAGAAATCTATTTTTTATCTTTTAGA
GATCATTATAAGTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10316.70 Da        Isoelectric Point: 4.6742

>AT20765 WP_000387490.1 NC_004116:c1986523-1986257 [Streptococcus agalactiae 2603V/R]
MEAIVYSHFRNNLKDYMKKVNDEFEPLIVVNKNPDENIVVLSQDSWESLQETIRLMENDYLSHKVINGISQVKEKQVTKH
GLIEVEDV

Download         Length: 267 bp

>AT20765 NC_004116:c1986523-1986257 [Streptococcus agalactiae 2603V/R]
ATGGAGGCTATTGTTTATTCACATTTTAGAAATAATTTAAAAGATTATATGAAGAAGGTCAATGATGAATTTGAGCCTTT
GATTGTAGTTAATAAAAATCCTGATGAAAATATAGTGGTTTTATCTCAAGATAGCTGGGAAAGTTTACAAGAAACGATTC
GTTTGATGGAAAATGATTATCTATCACATAAGGTTATTAATGGTATATCACAAGTTAAAGAGAAGCAAGTCACTAAACAT
GGTTTAATTGAGGTAGAAGATGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829IC12

Antitoxin

Source ID Structure
AlphaFold DB A0A829I9V6

References