Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 2007419..2007932 Replicon chromosome
Accession NZ_CP021867
Organism Streptococcus agalactiae strain SG-M25

Toxin (Protein)


Gene name yoeB Uniprot ID Q8DX49
Locus tag BB164_RS10610 Protein ID WP_000481712.1
Coordinates 2007419..2007673 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID Q8DX48
Locus tag BB164_RS10615 Protein ID WP_000387490.1
Coordinates 2007666..2007932 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BB164_RS10590 2005508..2005684 - 177 Protein_1947 conjugal transfer protein -
BB164_RS10595 2005705..2006115 - 411 WP_000390747.1 conjugal transfer protein -
BB164_RS10600 2006126..2006392 - 267 WP_001055037.1 hypothetical protein -
BB164_RS10605 2006413..2007366 - 954 WP_000565540.1 conjugal transfer protein -
BB164_RS10610 2007419..2007673 - 255 WP_000481712.1 Txe/YoeB family addiction module toxin Toxin
BB164_RS10615 2007666..2007932 - 267 WP_000387490.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
BB164_RS10620 2008077..2008550 - 474 WP_000560386.1 hypothetical protein -
BB164_RS10625 2008558..2009040 - 483 WP_000383283.1 antirestriction protein ArdA -
BB164_RS10630 2009093..2009365 - 273 WP_000017154.1 hypothetical protein -
BB164_RS10635 2009500..2010069 - 570 WP_000010056.1 hypothetical protein -
BB164_RS10640 2010072..2011421 - 1350 WP_000491712.1 AAA family ATPase -
BB164_RS10645 2011618..2011917 - 300 WP_000737133.1 helix-turn-helix domain-containing protein -
BB164_RS10650 2011901..2012278 - 378 WP_000287183.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element lsa(C) - 1994642..2032734 38092
flank IS/Tn - - 2004639..2005028 389


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(4-83)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10445.87 Da        Isoelectric Point: 6.7282

>T77731 WP_000481712.1 NZ_CP021867:c2007673-2007419 [Streptococcus agalactiae]
MFNFTEEAWKDYVSWQQEDKKILKRINRLIEDIKRDPFEGIGKPEPLKYHYSGAWSRRITEEHRLIYMIEDGEIYFLSFR
DHYK

Download         Length: 255 bp

>T77731 NZ_CP021867:c2007673-2007419 [Streptococcus agalactiae]
ATGTTTAATTTTACTGAAGAAGCATGGAAAGATTATGTTTCTTGGCAACAGGAAGATAAAAAAATCTTGAAACGAATTAA
TCGTTTGATAGAAGATATTAAAAGAGACCCATTTGAAGGCATTGGAAAACCAGAACCTTTAAAATACCATTATTCAGGGG
CTTGGTCTCGAAGAATTACAGAAGAACATAGGTTGATTTATATGATAGAAGATGGAGAAATCTATTTTTTATCTTTTAGA
GATCATTATAAGTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10316.70 Da        Isoelectric Point: 4.6742

>AT77731 WP_000387490.1 NZ_CP021867:c2007932-2007666 [Streptococcus agalactiae]
MEAIVYSHFRNNLKDYMKKVNDEFEPLIVVNKNPDENIVVLSQDSWESLQETIRLMENDYLSHKVINGISQVKEKQVTKH
GLIEVEDV

Download         Length: 267 bp

>AT77731 NZ_CP021867:c2007932-2007666 [Streptococcus agalactiae]
ATGGAGGCTATTGTTTATTCACATTTTAGAAATAATTTAAAAGATTATATGAAGAAGGTCAATGATGAATTTGAGCCTTT
GATTGTAGTTAATAAAAATCCTGATGAAAATATAGTGGTTTTATCTCAAGATAGCTGGGAAAGTTTACAAGAAACGATTC
GTTTGATGGAAAATGATTATCTATCACATAAGGTTATTAATGGTATATCACAAGTTAAAGAGAAGCAAGTCACTAAACAT
GGTTTAATTGAGGTAGAAGATGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829IC12

Antitoxin

Source ID Structure
AlphaFold DB A0A829I9V6

References