Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 1969014..1969527 Replicon chromosome
Accession NZ_CP059383
Organism Streptococcus agalactiae strain BJ01

Toxin (Protein)


Gene name yoeB Uniprot ID Q8DX49
Locus tag H1A19_RS10150 Protein ID WP_000481712.1
Coordinates 1969014..1969268 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID Q8DX48
Locus tag H1A19_RS10155 Protein ID WP_000387490.1
Coordinates 1969261..1969527 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H1A19_RS10130 1967104..1967268 - 165 Protein_1922 conjugal transfer protein -
H1A19_RS10135 1967300..1967710 - 411 WP_000390747.1 conjugal transfer protein -
H1A19_RS10140 1967721..1967987 - 267 WP_001055037.1 hypothetical protein -
H1A19_RS10145 1968008..1968961 - 954 WP_000565540.1 conjugal transfer protein -
H1A19_RS10150 1969014..1969268 - 255 WP_000481712.1 Txe/YoeB family addiction module toxin Toxin
H1A19_RS10155 1969261..1969527 - 267 WP_000387490.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
H1A19_RS10160 1969672..1970145 - 474 WP_000560386.1 hypothetical protein -
H1A19_RS10165 1970153..1970635 - 483 WP_000383283.1 antirestriction protein ArdA -
H1A19_RS10170 1970688..1970960 - 273 WP_000017154.1 hypothetical protein -
H1A19_RS10175 1971095..1971664 - 570 WP_000010056.1 hypothetical protein -
H1A19_RS10180 1971667..1973016 - 1350 WP_000491712.1 AAA family ATPase -
H1A19_RS10185 1973213..1973512 - 300 WP_000737133.1 helix-turn-helix domain-containing protein -
H1A19_RS10190 1973496..1973873 - 378 WP_000287183.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 1966235..1966624 389
inside Integrative and Conjugative Element - - 1956238..1988537 32299


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(4-83)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10445.87 Da        Isoelectric Point: 6.7282

>T168751 WP_000481712.1 NZ_CP059383:c1969268-1969014 [Streptococcus agalactiae]
MFNFTEEAWKDYVSWQQEDKKILKRINRLIEDIKRDPFEGIGKPEPLKYHYSGAWSRRITEEHRLIYMIEDGEIYFLSFR
DHYK

Download         Length: 255 bp

>T168751 NZ_CP076235:4114136-4114354 [Escherichia coli O157:H7]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10316.70 Da        Isoelectric Point: 4.6742

>AT168751 WP_000387490.1 NZ_CP059383:c1969527-1969261 [Streptococcus agalactiae]
MEAIVYSHFRNNLKDYMKKVNDEFEPLIVVNKNPDENIVVLSQDSWESLQETIRLMENDYLSHKVINGISQVKEKQVTKH
GLIEVEDV

Download         Length: 267 bp

>AT168751 NZ_CP076235:4113736-4114110 [Escherichia coli O157:H7]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACTCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829IC12

Antitoxin

Source ID Structure
AlphaFold DB A0A829I9V6

References