Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 1914646..1915159 Replicon chromosome
Accession NZ_CP118043
Organism Streptococcus agalactiae strain VSI63

Toxin (Protein)


Gene name yoeB Uniprot ID Q8DX49
Locus tag PUW57_RS09825 Protein ID WP_000481712.1
Coordinates 1914646..1914900 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID Q8DX48
Locus tag PUW57_RS09830 Protein ID WP_000387490.1
Coordinates 1914893..1915159 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PUW57_RS09810 (PUW57_09810) 1912932..1913342 - 411 WP_000390747.1 conjugal transfer protein -
PUW57_RS09815 (PUW57_09815) 1913353..1913619 - 267 WP_001055037.1 hypothetical protein -
PUW57_RS09820 (PUW57_09820) 1913640..1914593 - 954 WP_274999075.1 conjugal transfer protein -
PUW57_RS09825 (PUW57_09825) 1914646..1914900 - 255 WP_000481712.1 Txe/YoeB family addiction module toxin Toxin
PUW57_RS09830 (PUW57_09830) 1914893..1915159 - 267 WP_000387490.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
PUW57_RS09835 (PUW57_09835) 1915304..1915777 - 474 WP_000560386.1 hypothetical protein -
PUW57_RS09840 (PUW57_09840) 1915785..1916267 - 483 WP_000383283.1 antirestriction protein ArdA -
PUW57_RS09845 (PUW57_09845) 1916320..1916592 - 273 WP_000017154.1 hypothetical protein -
PUW57_RS09850 (PUW57_09850) 1916727..1917296 - 570 WP_000010056.1 hypothetical protein -
PUW57_RS09855 (PUW57_09855) 1917299..1918648 - 1350 WP_000491712.1 AAA family ATPase -
PUW57_RS09860 (PUW57_09860) 1918845..1919144 - 300 WP_000737133.1 helix-turn-helix transcriptional regulator -
PUW57_RS09865 (PUW57_09865) 1919128..1919505 - 378 WP_000287186.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 1901904..1942034 40130
flank IS/Tn - - 1911866..1912255 389


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(4-83)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10445.87 Da        Isoelectric Point: 6.7282

>T272706 WP_000481712.1 NZ_CP118043:c1914900-1914646 [Streptococcus agalactiae]
MFNFTEEAWKDYVSWQQEDKKILKRINRLIEDIKRDPFEGIGKPEPLKYHYSGAWSRRITEEHRLIYMIEDGEIYFLSFR
DHYK

Download         Length: 255 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10316.70 Da        Isoelectric Point: 4.6742

>AT272706 WP_000387490.1 NZ_CP118043:c1915159-1914893 [Streptococcus agalactiae]
MEAIVYSHFRNNLKDYMKKVNDEFEPLIVVNKNPDENIVVLSQDSWESLQETIRLMENDYLSHKVINGISQVKEKQVTKH
GLIEVEDV

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829IC12

Antitoxin

Source ID Structure
AlphaFold DB A0A829I9V6

References