Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 1801968..1802481 Replicon chromosome
Accession NZ_CP021770
Organism Streptococcus agalactiae strain B508

Toxin (Protein)


Gene name yoeB Uniprot ID Q8DX49
Locus tag CDH83_RS09235 Protein ID WP_000481712.1
Coordinates 1801968..1802222 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID Q8DX48
Locus tag CDH83_RS09240 Protein ID WP_000387490.1
Coordinates 1802215..1802481 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CDH83_RS09215 1800057..1800233 - 177 Protein_1732 conjugal transfer protein -
CDH83_RS09220 1800254..1800664 - 411 WP_000390747.1 conjugal transfer protein -
CDH83_RS09225 1800675..1800941 - 267 WP_001055037.1 hypothetical protein -
CDH83_RS09230 1800962..1801915 - 954 WP_000565540.1 conjugal transfer protein -
CDH83_RS09235 1801968..1802222 - 255 WP_000481712.1 Txe/YoeB family addiction module toxin Toxin
CDH83_RS09240 1802215..1802481 - 267 WP_000387490.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
CDH83_RS09245 1802626..1803099 - 474 WP_000560386.1 hypothetical protein -
CDH83_RS09250 1803107..1803589 - 483 WP_000383283.1 antirestriction protein ArdA -
CDH83_RS09255 1803642..1803914 - 273 WP_000017154.1 hypothetical protein -
CDH83_RS09260 1804049..1804618 - 570 WP_000010056.1 hypothetical protein -
CDH83_RS09265 1804621..1805970 - 1350 WP_000491712.1 AAA family ATPase -
CDH83_RS09270 1806167..1806466 - 300 WP_000737133.1 helix-turn-helix domain-containing protein -
CDH83_RS09275 1806450..1806827 - 378 WP_000287183.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Integrative and Conjugative Element - - 1789191..1821491 32300
flank IS/Tn - - 1799188..1799577 389


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(4-83)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10445.87 Da        Isoelectric Point: 6.7282

>T77357 WP_000481712.1 NZ_CP021770:c1802222-1801968 [Streptococcus agalactiae]
MFNFTEEAWKDYVSWQQEDKKILKRINRLIEDIKRDPFEGIGKPEPLKYHYSGAWSRRITEEHRLIYMIEDGEIYFLSFR
DHYK

Download         Length: 255 bp

>T77357 NZ_CP021770:c1802222-1801968 [Streptococcus agalactiae]
ATGTTTAATTTTACTGAAGAAGCATGGAAAGATTATGTTTCTTGGCAACAGGAAGATAAAAAAATCTTGAAACGAATTAA
TCGTTTGATAGAAGATATTAAAAGAGACCCATTTGAAGGCATTGGAAAACCAGAACCTTTAAAATACCATTATTCAGGGG
CTTGGTCTCGAAGAATTACAGAAGAACATAGGTTGATTTATATGATAGAAGATGGAGAAATCTATTTTTTATCTTTTAGA
GATCATTATAAGTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10316.70 Da        Isoelectric Point: 4.6742

>AT77357 WP_000387490.1 NZ_CP021770:c1802481-1802215 [Streptococcus agalactiae]
MEAIVYSHFRNNLKDYMKKVNDEFEPLIVVNKNPDENIVVLSQDSWESLQETIRLMENDYLSHKVINGISQVKEKQVTKH
GLIEVEDV

Download         Length: 267 bp

>AT77357 NZ_CP021770:c1802481-1802215 [Streptococcus agalactiae]
ATGGAGGCTATTGTTTATTCACATTTTAGAAATAATTTAAAAGATTATATGAAGAAGGTCAATGATGAATTTGAGCCTTT
GATTGTAGTTAATAAAAATCCTGATGAAAATATAGTGGTTTTATCTCAAGATAGCTGGGAAAGTTTACAAGAAACGATTC
GTTTGATGGAAAATGATTATCTATCACATAAGGTTATTAATGGTATATCACAAGTTAAAGAGAAGCAAGTCACTAAACAT
GGTTTAATTGAGGTAGAAGATGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829IC12

Antitoxin

Source ID Structure
AlphaFold DB A0A829I9V6

References