Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 1959558..1960071 Replicon chromosome
Accession NZ_CP044090
Organism Streptococcus agalactiae strain FDAARGOS_670

Toxin (Protein)


Gene name yoeB Uniprot ID Q8DX49
Locus tag FOB78_RS10375 Protein ID WP_000481712.1
Coordinates 1959817..1960071 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID Q8DX48
Locus tag FOB78_RS10370 Protein ID WP_000387490.1
Coordinates 1959558..1959824 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOB78_RS10335 1955212..1955589 + 378 WP_000287183.1 hypothetical protein -
FOB78_RS10340 1955573..1955872 + 300 WP_000737133.1 helix-turn-helix domain-containing protein -
FOB78_RS10345 1956069..1957418 + 1350 WP_000491711.1 AAA family ATPase -
FOB78_RS10350 1957421..1957990 + 570 WP_000010056.1 hypothetical protein -
FOB78_RS10355 1958125..1958397 + 273 WP_000017154.1 hypothetical protein -
FOB78_RS10360 1958450..1958932 + 483 WP_000383283.1 antirestriction protein ArdA -
FOB78_RS10365 1958940..1959413 + 474 WP_000560386.1 hypothetical protein -
FOB78_RS10370 1959558..1959824 + 267 WP_000387490.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
FOB78_RS10375 1959817..1960071 + 255 WP_000481712.1 Txe/YoeB family addiction module toxin Toxin
FOB78_RS10380 1960124..1961077 + 954 WP_000565539.1 conjugal transfer protein -
FOB78_RS10385 1961098..1961364 + 267 WP_001055037.1 hypothetical protein -
FOB78_RS10390 1961375..1961785 + 411 WP_000390747.1 conjugal transfer protein -
FOB78_RS10395 1961806..1961982 + 177 Protein_1898 conjugal transfer protein -
FOB78_RS10400 1962046..1962851 + 806 WP_088181596.1 IS5 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Integrative and Conjugative Element - - 1931523..1979629 48106
flank IS/Tn - - 1962462..1962851 389


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(4-83)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10445.87 Da        Isoelectric Point: 6.7282

>T140037 WP_000481712.1 NZ_CP044090:1959817-1960071 [Streptococcus agalactiae]
MFNFTEEAWKDYVSWQQEDKKILKRINRLIEDIKRDPFEGIGKPEPLKYHYSGAWSRRITEEHRLIYMIEDGEIYFLSFR
DHYK

Download         Length: 255 bp

>T140037 NZ_CP058879:c2133857-2133750 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10316.70 Da        Isoelectric Point: 4.6742

>AT140037 WP_000387490.1 NZ_CP044090:1959558-1959824 [Streptococcus agalactiae]
MEAIVYSHFRNNLKDYMKKVNDEFEPLIVVNKNPDENIVVLSQDSWESLQETIRLMENDYLSHKVINGISQVKEKQVTKH
GLIEVEDV

Download         Length: 267 bp

>AT140037 NZ_CP058879:2133905-2133971 [Escherichia coli]
GTTCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTAAACCTCTCAACGTGCGGGGGTTTTCTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829IC12

Antitoxin

Source ID Structure
AlphaFold DB A0A829I9V6

References