Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | yefM-yoeB (relBE)/YoeB-RelB |
Location | 1959558..1960071 | Replicon | chromosome |
Accession | NZ_CP044090 | ||
Organism | Streptococcus agalactiae strain FDAARGOS_670 |
Toxin (Protein)
Gene name | yoeB | Uniprot ID | Q8DX49 |
Locus tag | FOB78_RS10375 | Protein ID | WP_000481712.1 |
Coordinates | 1959817..1960071 (+) | Length | 85 a.a. |
Antitoxin (Protein)
Gene name | yefM | Uniprot ID | Q8DX48 |
Locus tag | FOB78_RS10370 | Protein ID | WP_000387490.1 |
Coordinates | 1959558..1959824 (+) | Length | 89 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
FOB78_RS10335 | 1955212..1955589 | + | 378 | WP_000287183.1 | hypothetical protein | - |
FOB78_RS10340 | 1955573..1955872 | + | 300 | WP_000737133.1 | helix-turn-helix domain-containing protein | - |
FOB78_RS10345 | 1956069..1957418 | + | 1350 | WP_000491711.1 | AAA family ATPase | - |
FOB78_RS10350 | 1957421..1957990 | + | 570 | WP_000010056.1 | hypothetical protein | - |
FOB78_RS10355 | 1958125..1958397 | + | 273 | WP_000017154.1 | hypothetical protein | - |
FOB78_RS10360 | 1958450..1958932 | + | 483 | WP_000383283.1 | antirestriction protein ArdA | - |
FOB78_RS10365 | 1958940..1959413 | + | 474 | WP_000560386.1 | hypothetical protein | - |
FOB78_RS10370 | 1959558..1959824 | + | 267 | WP_000387490.1 | type II toxin-antitoxin system prevent-host-death family antitoxin | Antitoxin |
FOB78_RS10375 | 1959817..1960071 | + | 255 | WP_000481712.1 | Txe/YoeB family addiction module toxin | Toxin |
FOB78_RS10380 | 1960124..1961077 | + | 954 | WP_000565539.1 | conjugal transfer protein | - |
FOB78_RS10385 | 1961098..1961364 | + | 267 | WP_001055037.1 | hypothetical protein | - |
FOB78_RS10390 | 1961375..1961785 | + | 411 | WP_000390747.1 | conjugal transfer protein | - |
FOB78_RS10395 | 1961806..1961982 | + | 177 | Protein_1898 | conjugal transfer protein | - |
FOB78_RS10400 | 1962046..1962851 | + | 806 | WP_088181596.1 | IS5 family transposase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
inside | Integrative and Conjugative Element | - | - | 1931523..1979629 | 48106 | ||
flank | IS/Tn | - | - | 1962462..1962851 | 389 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 85 a.a. Molecular weight: 10445.87 Da Isoelectric Point: 6.7282
>T140037 WP_000481712.1 NZ_CP044090:1959817-1960071 [Streptococcus agalactiae]
MFNFTEEAWKDYVSWQQEDKKILKRINRLIEDIKRDPFEGIGKPEPLKYHYSGAWSRRITEEHRLIYMIEDGEIYFLSFR
DHYK
MFNFTEEAWKDYVSWQQEDKKILKRINRLIEDIKRDPFEGIGKPEPLKYHYSGAWSRRITEEHRLIYMIEDGEIYFLSFR
DHYK
Download Length: 255 bp
>T140037 NZ_CP058879:c2133857-2133750 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA
Antitoxin
Download Length: 89 a.a. Molecular weight: 10316.70 Da Isoelectric Point: 4.6742
>AT140037 WP_000387490.1 NZ_CP044090:1959558-1959824 [Streptococcus agalactiae]
MEAIVYSHFRNNLKDYMKKVNDEFEPLIVVNKNPDENIVVLSQDSWESLQETIRLMENDYLSHKVINGISQVKEKQVTKH
GLIEVEDV
MEAIVYSHFRNNLKDYMKKVNDEFEPLIVVNKNPDENIVVLSQDSWESLQETIRLMENDYLSHKVINGISQVKEKQVTKH
GLIEVEDV
Download Length: 267 bp
>AT140037 NZ_CP058879:2133905-2133971 [Escherichia coli]
GTTCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTAAACCTCTCAACGTGCGGGGGTTTTCTC
GTTCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTAAACCTCTCAACGTGCGGGGGTTTTCTC
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A829IC12 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A829I9V6 |