Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 2075307..2075820 Replicon chromosome
Accession NZ_CP119576
Organism Streptococcus agalactiae strain Guangzhou-SAG092

Toxin (Protein)


Gene name yoeB Uniprot ID Q8DX49
Locus tag P1I87_RS10610 Protein ID WP_000481712.1
Coordinates 2075307..2075561 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID Q8DX48
Locus tag P1I87_RS10615 Protein ID WP_000387490.1
Coordinates 2075554..2075820 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P1I87_RS10595 (P1I87_10595) 2073593..2074003 - 411 WP_000390747.1 conjugal transfer protein -
P1I87_RS10600 (P1I87_10600) 2074014..2074280 - 267 WP_001055037.1 hypothetical protein -
P1I87_RS10605 (P1I87_10605) 2074301..2075254 - 954 WP_000565540.1 conjugal transfer protein -
P1I87_RS10610 (P1I87_10610) 2075307..2075561 - 255 WP_000481712.1 Txe/YoeB family addiction module toxin Toxin
P1I87_RS10615 (P1I87_10615) 2075554..2075820 - 267 WP_000387490.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
P1I87_RS10620 (P1I87_10620) 2075965..2076438 - 474 WP_000560386.1 hypothetical protein -
P1I87_RS10625 (P1I87_10625) 2076446..2076928 - 483 WP_000383283.1 antirestriction protein ArdA -
P1I87_RS10630 (P1I87_10630) 2076981..2077253 - 273 WP_000017154.1 hypothetical protein -
P1I87_RS10635 (P1I87_10635) 2077388..2077693 - 306 WP_000350427.1 hypothetical protein -
P1I87_RS10640 (P1I87_10640) 2077960..2079309 - 1350 WP_000491712.1 AAA family ATPase -
P1I87_RS10645 (P1I87_10645) 2079506..2079805 - 300 WP_000737133.1 helix-turn-helix transcriptional regulator -
P1I87_RS10650 (P1I87_10650) 2079789..2080166 - 378 WP_000287186.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 2062565..2102865 40300
flank IS/Tn - - 2072527..2072916 389


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(4-83)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10445.87 Da        Isoelectric Point: 6.7282

>T274223 WP_000481712.1 NZ_CP119576:c2075561-2075307 [Streptococcus agalactiae]
MFNFTEEAWKDYVSWQQEDKKILKRINRLIEDIKRDPFEGIGKPEPLKYHYSGAWSRRITEEHRLIYMIEDGEIYFLSFR
DHYK

Download         Length: 255 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10316.70 Da        Isoelectric Point: 4.6742

>AT274223 WP_000387490.1 NZ_CP119576:c2075820-2075554 [Streptococcus agalactiae]
MEAIVYSHFRNNLKDYMKKVNDEFEPLIVVNKNPDENIVVLSQDSWESLQETIRLMENDYLSHKVINGISQVKEKQVTKH
GLIEVEDV

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829IC12

Antitoxin

Source ID Structure
AlphaFold DB A0A829I9V6

References