Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 2064165..2064678 Replicon chromosome
Accession NZ_AP018935
Organism Streptococcus agalactiae strain HU-GS5823

Toxin (Protein)


Gene name yoeB Uniprot ID Q8DX49
Locus tag EL269_RS10780 Protein ID WP_000481712.1
Coordinates 2064165..2064419 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID Q8DX48
Locus tag EL269_RS10785 Protein ID WP_000387490.1
Coordinates 2064412..2064678 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL269_RS10760 2062254..2062430 - 177 Protein_1970 conjugal transfer protein -
EL269_RS10765 2062451..2062861 - 411 WP_000390747.1 conjugal transfer protein -
EL269_RS10770 2062872..2063138 - 267 WP_001055037.1 hypothetical protein -
EL269_RS10775 2063159..2064112 - 954 WP_000565540.1 conjugal transfer protein -
EL269_RS10780 2064165..2064419 - 255 WP_000481712.1 Txe/YoeB family addiction module toxin Toxin
EL269_RS10785 2064412..2064678 - 267 WP_000387490.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
EL269_RS10790 2064823..2065296 - 474 WP_000560386.1 hypothetical protein -
EL269_RS10795 2065304..2065786 - 483 WP_000383283.1 antirestriction protein ArdA -
EL269_RS10800 2065839..2066111 - 273 WP_000017154.1 hypothetical protein -
EL269_RS10805 2066246..2066815 - 570 WP_000010056.1 hypothetical protein -
EL269_RS10810 2066818..2068167 - 1350 WP_000491712.1 AAA family ATPase -
EL269_RS10815 2068364..2068663 - 300 WP_000737133.1 helix-turn-helix domain-containing protein -
EL269_RS10820 2068647..2069024 - 378 WP_000287183.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Integrative and Conjugative Element - - 2051388..2083757 32369
flank IS/Tn - - 2061385..2061774 389


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(4-83)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10445.87 Da        Isoelectric Point: 6.7282

>T32464 WP_000481712.1 NZ_AP018935:c2064419-2064165 [Streptococcus agalactiae]
MFNFTEEAWKDYVSWQQEDKKILKRINRLIEDIKRDPFEGIGKPEPLKYHYSGAWSRRITEEHRLIYMIEDGEIYFLSFR
DHYK

Download         Length: 255 bp

>T32464 NZ_AP018935:c2064419-2064165 [Streptococcus agalactiae]
ATGTTTAATTTTACTGAAGAAGCATGGAAAGATTATGTTTCTTGGCAACAGGAAGATAAAAAAATCTTGAAACGAATTAA
TCGTTTGATAGAAGATATTAAAAGAGACCCATTTGAAGGCATTGGAAAACCAGAACCTTTAAAATACCATTATTCAGGGG
CTTGGTCTCGAAGAATTACAGAAGAACATAGGTTGATTTATATGATAGAAGATGGAGAAATCTATTTTTTATCTTTTAGA
GATCATTATAAGTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10316.70 Da        Isoelectric Point: 4.6742

>AT32464 WP_000387490.1 NZ_AP018935:c2064678-2064412 [Streptococcus agalactiae]
MEAIVYSHFRNNLKDYMKKVNDEFEPLIVVNKNPDENIVVLSQDSWESLQETIRLMENDYLSHKVINGISQVKEKQVTKH
GLIEVEDV

Download         Length: 267 bp

>AT32464 NZ_AP018935:c2064678-2064412 [Streptococcus agalactiae]
ATGGAGGCTATTGTTTATTCACATTTTAGAAATAATTTAAAAGATTATATGAAGAAGGTCAATGATGAATTTGAGCCTTT
GATTGTAGTTAATAAAAATCCTGATGAAAATATAGTGGTTTTATCTCAAGATAGCTGGGAAAGTTTACAAGAAACGATTC
GTTTGATGGAAAATGATTATCTATCACATAAGGTTATTAATGGTATATCACAAGTTAAAGAGAAGCAAGTCACTAAACAT
GGTTTAATTGAGGTAGAAGATGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829IC12

Antitoxin

Source ID Structure
AlphaFold DB A0A829I9V6

References