Detailed information of component protein


Summary

Component ID T6CP014917
Component protein type TssD
T6SS ID (Type) T6SS01172 experimental (Type i4b)
Strain Acinetobacter baumannii ATCC 17978
Replicon chromosome
Sequence Protein sequence (168 a.a.); Nucleotide sequence (504 bp)
Reference
[1] Ruiz FM, Santillana E, Spínola-Amilibia M, et al. Crystal Structure of Hcp from Acinetobacter baumannii: A Component of the Type VI Secretion System. PLoS One. 2015 Jun 16;10(6):e0129691. doi: 10.1371/journal.pone.0129691. eCollection 2015. PMID: 26079269
[2] Weber BS, Miyata ST, Iwashkiw JA, et al. Genomic and functional analysis of the type VI secretion system in Acinetobacter. PLoS One. 2013;8(1):e55142. doi: 10.1371/journal.pone.0055142. Epub 2013 Jan 24. PMID: 23365692
[3] Carruthers MD, Nicholson PA, Tracy EN, et al. Acinetobacter baumannii utilizes a type VI secretion system for bacterial competition. PLoS One. 2013;8(3):e59388. doi: 10.1371/journal.pone.0059388. Epub 2013 Mar 19. PMID: 23527179
[4] Eijkelkamp BA, Stroeher UH, Hassan KA, et al. H-NS plays a role in expression of Acinetobacter baumannii virulence features. Infect Immun. 2013 Jul;81(7):2574-83. doi: 10.1128/IAI.00065-13. Epub 2013 May 6. PMID: 23649094
experimental Experimental investigation has been performed on this T6SS
External database links

Locus tag (Gene) G6543_RS11120
Coordinate (Strand) 2324206..2324709 (-)
NCBI ID WP_000653195.1
RefSeq NZ_CP049363
Uniprot ID A0A0R1C1Y7_ACINO, A0A7U4F766_ACIBA, A0A009RJK0_9GAMM, A0A010KAB5_9GAMM, A0A022IZT8_9GAMM, A0A013UTK5_9GAMM, A0A013TMC1_9GAMM, A0A0E1PSF3_ACIBA, A0A0J0ZX19_ACIBA, N8S3X6_9GAMM, A0A1V2V3D7_9GAMM, A0A4R6CNR4_9GAMM, A0A3R9CCF9_9GAMM, A0A3R9GB64_9GAMM, A0A7U3XZ91_ACIBC, R9RIP4_ACIBA, A0A1A0GM72_ACICA, A0A7U3Y5A8_ACIB5, A0A143IYH8_ACIPI, A0A654KYA4_ACIBM, B0VB03_ACIBY, A0A5K6CS27_ACIB3, D0C8P3_ACIB2, F0KJP8_ACICP, L9MI81_9GAMM, A0A385EU73_ACIBA
KEGG ID abz:ABZJ_01456, abau:IX87_03965, abk:LX00_06415, abw:BL01_13265, acc:BDGL_000641, aby:ABAYE2413
PDB ID -
Pfam domain hit(s)

Domain Pfam ID E-value Aligned region
T6SS_HCP PF05638.14 5.4e-40 5..139
Transmembrane helices

  • Transmembrane helices are predicted using TMHMM 2.0 software.

Prediction                 Region     Sequence
Outside 1-167 MKDIYVEFRGKYKVDGESRDSEHKGWLEVNSWSHNIRQPKSATSSSVGGHTAERVEHSDMVFVKDLDATSPKLWEACSAGYTFDEVQIDFYRANGDKRIKYLQIKLKHVLVSSVTPTVNEEGVPTEAFGLKYAAVEWTYNQQDINGTAKGAVTKKWSLSNNTASYAA


Signal peptides
  • Sec/SPI: "standard" secretory signal peptides transported by the Sec translocon and cleaved by Signal Peptidase I (Lep).
  • Sec/SPII: lipoprotein signal peptides transported by the Sec translocon and cleaved by Signal Peptidase II (Lsp).
  • Tat/SPI: Tat signal peptides transported by the Tat translocon and cleaved by Signal Peptidase I (Lep).
Prediction        Probability Cleavage site Signal peptide sequence
Other 0.9825 - -


  Protein sequence: 168 a.a.    

>T6CP014917 NZ_CP049363:c2324709-2324206 [Acinetobacter baumannii] [TssD]
MKDIYVEFRGKYKVDGESRDSEHKGWLEVNSWSHNIRQPKSATSSSVGGHTAERVEHSDMVFVKDLDATSPKLWEACSAG
YTFDEVQIDFYRANGDKRIKYLQIKLKHVLVSSVTPTVNEEGVPTEAFGLKYAAVEWTYNQQDINGTAKGAVTKKWSLSN
NTASYAA*

  Nucleotide sequence: 504 bp    

>T6CP014917 NZ_CP049363:c2324709-2324206 [Acinetobacter baumannii] [TssD]
ATGAAAGATATATACGTTGAGTTTCGCGGTAAATATAAAGTTGATGGAGAATCTCGTGATTCTGAGCACAAAGGTTGGTT
AGAAGTTAACTCTTGGTCTCATAACATCCGTCAACCTAAATCTGCTACTTCAAGTAGTGTAGGCGGCCACACTGCTGAAC
GTGTTGAACATTCTGACATGGTTTTCGTGAAAGACTTAGACGCAACTAGCCCTAAATTATGGGAAGCTTGTTCAGCTGGT
TATACATTTGATGAAGTACAAATCGACTTCTATCGCGCAAATGGCGATAAACGTATCAAGTACTTACAAATCAAATTGAA
GCACGTTTTAGTTTCTAGTGTGACTCCAACTGTTAACGAAGAAGGCGTTCCTACAGAAGCATTCGGTTTGAAATATGCTG
CTGTTGAGTGGACTTATAACCAACAAGATATTAACGGTACTGCTAAAGGTGCTGTTACTAAGAAATGGTCACTTTCTAAT
AATACAGCTTCTTACGCAGCGTAA