Detailed information of component protein


Summary

Component ID T6CP014913
Component protein type TssH
T6SS ID (Type) T6SS01172 experimental (Type i4b)
Strain Acinetobacter baumannii ATCC 17978
Replicon chromosome
Sequence Protein sequence (894 a.a.); Nucleotide sequence (2682 bp)
Reference
[1] Ruiz FM, Santillana E, Spínola-Amilibia M, et al. Crystal Structure of Hcp from Acinetobacter baumannii: A Component of the Type VI Secretion System. PLoS One. 2015 Jun 16;10(6):e0129691. doi: 10.1371/journal.pone.0129691. eCollection 2015. PMID: 26079269
[2] Weber BS, Miyata ST, Iwashkiw JA, et al. Genomic and functional analysis of the type VI secretion system in Acinetobacter. PLoS One. 2013;8(1):e55142. doi: 10.1371/journal.pone.0055142. Epub 2013 Jan 24. PMID: 23365692
[3] Carruthers MD, Nicholson PA, Tracy EN, et al. Acinetobacter baumannii utilizes a type VI secretion system for bacterial competition. PLoS One. 2013;8(3):e59388. doi: 10.1371/journal.pone.0059388. Epub 2013 Mar 19. PMID: 23527179
[4] Eijkelkamp BA, Stroeher UH, Hassan KA, et al. H-NS plays a role in expression of Acinetobacter baumannii virulence features. Infect Immun. 2013 Jul;81(7):2574-83. doi: 10.1128/IAI.00065-13. Epub 2013 May 6. PMID: 23649094
experimental Experimental investigation has been performed on this T6SS
External database links

Locus tag (Gene) G6543_RS11075
Coordinate (Strand) 2310649..2313330 (-)
NCBI ID WP_156190132.1
RefSeq NZ_CP049363
Uniprot ID UPI0012E13931
KEGG ID -
PDB ID -
Pfam domain hit(s)

Domain Pfam ID E-value Aligned region
AAA_2 PF07724.16 3.2e-42 606..774
AAA_lid_9 PF17871.3 1.3e-24 370..462
AAA PF00004.31 1.2e-11 230..343
ClpB_D2-small PF10431.11 2.3e-11 780..850
Transmembrane helices

  • Transmembrane helices are predicted using TMHMM 2.0 software.

Prediction                 Region     Sequence
Outside 1-893 MMSSLKILITKLSTAARTALEKSANACVLQQNYEIEIEHLFLELLNQPLENDLKILLKKYKISADALADDLKETISQLPKGNTRTPIFAKSIVRLFEQAWLLASAEQNPVIRSGHLLVALLTAPDLYQIATRASSLFDLFPIDSMKHKFLEICEKSVEQQEESKTSSQADELEQAVTPTAKTQKTPALDQYTINLTEKAKNGGIDPVIGREYEIRLMLDILMRRRQNNPILTGEPGVGKTAVVEGLALKIAQGLVPEALKNVHLHVLDMGLLQAGASVKGEFENRLKQVIQEVQSSAHPIILFIDEAHTLIGAGGQAGQNDAANLLKPALARGELRTIAATTWAEYKQYFEKDAALSRRFQVVKVEEPTEEVAVDMLRAMIPVMQKHFNLQIDDEAIVTAVHASHRYISGRQLPDKAVSVLDTAAARVALTQNAQPVKLDQLKAQEHNLKLEQQILENEHRQIPIHHERLENLKSQLESLQSEIQETQEQWQKELELVRKIQELEAQSHSNESEAYDQINLIRKDLADIQGQQPLVFERVNSQIINEIISDWTGIPVGKMVNDEIKQILTLEDKLGERVMGQDYALTQLVQGIKTSKAKLEDPNKPQGVFLLVGPSGVGKTETALALANELYGGEQHLITINMSEYQEAHTVSSLKGAPPGYVGYGQGGVLTEAVRRNPYSVVLLDEIEKAHSDVQELFYQVFDKGTLEDGEGRVIDFKNTTIILTSNTGSSAIMQACLNQPVEEWPTAEDLIEHLKPSLYKQFKPAFLGRMRVVPYFPLHDDLLVRIIKHKLGKITARIEKQYGTEVQYSDDLVELLLSRCTEVDSGARNVDNILNSTVLPALATEILVALADQKLPKLIMIDAKDDEIQYLLDPVAKPAKKRTSKKLKSEV


Signal peptides
  • Sec/SPI: "standard" secretory signal peptides transported by the Sec translocon and cleaved by Signal Peptidase I (Lep).
  • Sec/SPII: lipoprotein signal peptides transported by the Sec translocon and cleaved by Signal Peptidase II (Lsp).
  • Tat/SPI: Tat signal peptides transported by the Tat translocon and cleaved by Signal Peptidase I (Lep).
Prediction        Probability Cleavage site Signal peptide sequence
Other 0.9493 - -


  Protein sequence: 894 a.a.    

>T6CP014913 NZ_CP049363:c2313330-2310649 [Acinetobacter baumannii] [TssH]
MMSSLKILITKLSTAARTALEKSANACVLQQNYEIEIEHLFLELLNQPLENDLKILLKKYKISADALADDLKETISQLPK
GNTRTPIFAKSIVRLFEQAWLLASAEQNPVIRSGHLLVALLTAPDLYQIATRASSLFDLFPIDSMKHKFLEICEKSVEQQ
EESKTSSQADELEQAVTPTAKTQKTPALDQYTINLTEKAKNGGIDPVIGREYEIRLMLDILMRRRQNNPILTGEPGVGKT
AVVEGLALKIAQGLVPEALKNVHLHVLDMGLLQAGASVKGEFENRLKQVIQEVQSSAHPIILFIDEAHTLIGAGGQAGQN
DAANLLKPALARGELRTIAATTWAEYKQYFEKDAALSRRFQVVKVEEPTEEVAVDMLRAMIPVMQKHFNLQIDDEAIVTA
VHASHRYISGRQLPDKAVSVLDTAAARVALTQNAQPVKLDQLKAQEHNLKLEQQILENEHRQIPIHHERLENLKSQLESL
QSEIQETQEQWQKELELVRKIQELEAQSHSNESEAYDQINLIRKDLADIQGQQPLVFERVNSQIINEIISDWTGIPVGKM
VNDEIKQILTLEDKLGERVMGQDYALTQLVQGIKTSKAKLEDPNKPQGVFLLVGPSGVGKTETALALANELYGGEQHLIT
INMSEYQEAHTVSSLKGAPPGYVGYGQGGVLTEAVRRNPYSVVLLDEIEKAHSDVQELFYQVFDKGTLEDGEGRVIDFKN
TTIILTSNTGSSAIMQACLNQPVEEWPTAEDLIEHLKPSLYKQFKPAFLGRMRVVPYFPLHDDLLVRIIKHKLGKITARI
EKQYGTEVQYSDDLVELLLSRCTEVDSGARNVDNILNSTVLPALATEILVALADQKLPKLIMIDAKDDEIQYLLDPVAKP
AKKRTSKKLKSEV*

  Nucleotide sequence: 2682 bp    

>T6CP014913 NZ_CP049363:c2313330-2310649 [Acinetobacter baumannii] [TssH]
ATGATGAGTAGTTTAAAAATTTTAATTACAAAACTTTCTACAGCTGCACGCACTGCTTTAGAAAAATCTGCTAATGCTTG
TGTTCTTCAGCAAAACTACGAAATTGAAATTGAACATTTATTTTTAGAGTTACTTAATCAGCCTTTAGAAAACGATTTAA
AAATTTTATTAAAAAAATATAAAATCTCAGCCGATGCTTTAGCAGATGATTTAAAAGAAACAATTTCTCAATTACCAAAA
GGTAATACACGTACTCCAATTTTTGCTAAATCAATTGTTCGTTTATTTGAACAAGCTTGGTTATTGGCTTCAGCAGAACA
AAATCCTGTCATTCGTAGTGGTCATTTACTGGTTGCATTATTAACTGCACCTGACCTCTATCAAATTGCAACGAGAGCTT
CGAGTTTATTCGATCTTTTCCCGATAGACTCAATGAAACATAAGTTTCTCGAAATTTGTGAAAAAAGTGTAGAACAACAA
GAAGAATCAAAAACATCTTCACAAGCAGATGAATTAGAACAAGCCGTGACTCCAACTGCAAAAACTCAAAAAACACCTGC
TTTAGATCAATATACAATTAATTTAACTGAAAAAGCGAAGAATGGTGGGATTGACCCTGTTATTGGGCGTGAATATGAAA
TTCGTTTGATGCTCGATATTTTAATGCGTAGACGTCAGAACAACCCAATTTTAACTGGTGAGCCAGGTGTAGGTAAAACA
GCTGTAGTTGAAGGGTTGGCTTTAAAAATTGCTCAAGGTTTAGTTCCTGAGGCATTAAAAAATGTACATTTGCATGTTTT
AGATATGGGGCTTTTGCAAGCTGGGGCAAGTGTTAAAGGTGAATTTGAAAACCGTTTAAAGCAAGTTATTCAAGAAGTCC
AATCATCGGCTCATCCTATTATTTTATTTATTGATGAAGCACATACGCTTATTGGAGCTGGTGGCCAAGCGGGGCAAAAC
GATGCTGCCAATCTTTTAAAACCTGCACTTGCACGTGGCGAGTTACGTACTATTGCTGCAACGACATGGGCAGAATATAA
ACAGTATTTTGAGAAAGATGCTGCATTGAGCCGCCGTTTTCAGGTGGTAAAGGTTGAAGAACCGACCGAAGAAGTTGCTG
TAGATATGTTACGTGCAATGATTCCTGTAATGCAAAAGCACTTTAATTTACAAATTGATGATGAAGCAATTGTAACGGCT
GTACATGCCTCTCATCGCTATATTAGTGGTCGTCAACTCCCAGACAAAGCAGTAAGTGTTCTTGATACTGCGGCAGCGCG
TGTAGCTTTGACCCAAAATGCACAGCCAGTCAAACTTGATCAATTAAAAGCACAAGAACATAACTTAAAGCTTGAGCAAC
AGATTTTGGAAAATGAACACCGTCAGATTCCAATACATCATGAAAGATTAGAAAATCTGAAAAGCCAACTAGAGTCATTA
CAAAGTGAGATCCAAGAGACTCAGGAACAATGGCAAAAAGAATTAGAGCTAGTTCGTAAAATTCAGGAATTAGAAGCGCA
GAGCCATTCTAATGAGTCTGAAGCCTACGATCAGATTAATTTAATACGCAAAGACCTTGCTGATATTCAGGGACAACAGC
CGTTAGTTTTTGAGCGAGTAAACTCTCAGATCATCAATGAAATTATTTCTGATTGGACTGGTATTCCTGTTGGGAAAATG
GTCAATGATGAAATTAAGCAGATTTTAACGCTTGAAGATAAATTAGGTGAGCGTGTAATGGGGCAAGATTATGCACTTAC
ACAATTAGTTCAAGGGATTAAAACTTCAAAAGCTAAATTAGAAGATCCAAATAAACCTCAAGGGGTGTTCCTTTTAGTTG
GACCTAGTGGGGTTGGTAAAACCGAAACTGCTTTAGCCTTGGCTAATGAGTTATATGGCGGTGAACAGCATTTAATCACG
ATTAATATGTCTGAGTATCAAGAAGCACATACTGTCTCTTCGCTTAAAGGTGCTCCTCCAGGCTATGTGGGCTATGGTCA
GGGTGGGGTTTTAACTGAAGCTGTACGTCGTAATCCTTATAGTGTTGTGTTACTCGACGAAATTGAAAAAGCACATAGCG
ATGTTCAGGAGTTGTTCTATCAAGTATTTGATAAAGGTACTTTAGAGGATGGTGAAGGGCGCGTTATTGATTTTAAAAAC
ACGACAATCATATTAACTTCAAATACGGGCTCGAGTGCAATTATGCAGGCATGTTTAAATCAGCCTGTAGAAGAATGGCC
TACCGCGGAAGATTTAATCGAACATTTAAAACCGAGTTTATATAAACAGTTTAAGCCAGCCTTCTTAGGGCGTATGAGAG
TTGTGCCATATTTCCCATTGCATGATGATTTATTGGTTCGAATTATTAAACATAAATTGGGCAAAATTACTGCTCGAATT
GAAAAACAATATGGAACGGAAGTTCAATATTCAGATGACTTGGTCGAGTTGCTACTCAGCCGTTGTACTGAAGTGGATAG
TGGCGCCCGTAATGTTGATAACATCTTAAATTCTACAGTTTTACCTGCTTTGGCAACTGAAATTTTAGTGGCGTTAGCAG
ATCAAAAATTGCCGAAATTGATCATGATTGATGCAAAAGATGACGAGATCCAATATTTACTAGATCCTGTGGCGAAGCCT
GCTAAAAAACGGACTAGTAAAAAGTTGAAATCAGAAGTTTAA