SecReT6, T6SS database

Detailed information of component protein

Summary

Component ID	T6CP007576
Component protein type	TssD
T6SS ID (Type)	T6SS00720 (Type i5)
Strain	Vibrio parahaemolyticus BB22OP
Replicon	chromosome II
Sequence	Protein sequence (160 a.a.); Nucleotide sequence (480 bp)
Reference	[1] Gode-Potratz CJ, McCarter LL. Quorum sensing and silencing in Vibrio parahaemolyticus. J Bacteriol. 2011 Aug;193(16):4224-37. doi: 10.1128/JB.00432-11. Epub 2011 Jun 24. PMID: 21705592 [2] Fridman CM, Keppel K, Gerlic M, et al. A comparative genomics methodology reveals a widespread family of membrane-disrupting T6SS effectors. Nat Commun. 2020 Feb 27;11(1):1085. doi: 10.1038/s41467-020-14951-4. PMID: 32109231

Experimental investigation has been performed on this T6SS

External database links

Locus tag (Gene)	VPBB_RS19920
Coordinate (Strand)	1050543..1051022 (-)
NCBI ID	WP_005375967.1
RefSeq	NC_019971
Uniprot ID	A0A4P8G3D2_9VIBR, A0A2I3CRH4_VIBAX, S5J041_VIBPH, A0A559P044_9VIBR, Q87HD8_VIBPA, A0A7Y3Q745_9VIBR, A0A7Y3VM68_9VIBR, A0A0T7E196_9VIBR, C0LZR3_VIBAL, A0A072J8B2_VIBPH, D0X0J5_VIBAL
KEGG ID	vnl:D3H41_17720, vpf:M634_23055, vpa:VPA1027, vag:N646_4398
PDB ID	-

Pfam domain hit(s)

Domain	Pfam ID	E-value	Aligned region
T6SS_HCP	PF05638.14	1.2e-28	6..133

Transmembrane helices

Transmembrane helices are predicted using TMHMM 2.0 software.

Prediction	Region	Sequence
Outside	1-159	MQSNTYLKYADIKGEATAEQYKDLITLLSVDWSVGREISSYTGTAMDREASATRLYDLTITKLQDRSSPDLFKEATIGKGKPAVFHITKQGEKVEEIMKIELTDAMISNYSVSIQDDRPVETITISYTEMMMTVTPTDDKNNTSAPLVYGYSGVKGQQM

Signal peptides

Signal peptides and corresponding cleavage sites are predicted using SignalP 5.0 software.

Sec/SPI: "standard" secretory signal peptides transported by the Sec translocon and cleaved by Signal Peptidase I (Lep).

Sec/SPII: lipoprotein signal peptides transported by the Sec translocon and cleaved by Signal Peptidase II (Lsp).

Tat/SPI: Tat signal peptides transported by the Tat translocon and cleaved by Signal Peptidase I (Lep).

Prediction	Probability	Cleavage site	Signal peptide sequence
Other	0.9833	-	-

Protein sequence: 160 a.a.

						>T6CP007576 NC_019971:c1051022-1050543 [Vibrio parahaemolyticus BB22OP] [TssD]
MQSNTYLKYADIKGEATAEQYKDLITLLSVDWSVGREISSYTGTAMDREASATRLYDLTITKLQDRSSPDLFKEATIGKG
KPAVFHITKQGEKVEEIMKIELTDAMISNYSVSIQDDRPVETITISYTEMMMTVTPTDDKNNTSAPLVYGYSGVKGQQM*					

Nucleotide sequence: 480 bp

						>T6CP007576 NC_019971:c1051022-1050543 [Vibrio parahaemolyticus BB22OP] [TssD]
ATGCAGTCTAATACGTATCTTAAATACGCAGATATTAAAGGTGAAGCGACAGCGGAACAATATAAGGATTTAATTACACT
ACTATCTGTAGATTGGAGTGTTGGTCGTGAAATTTCTTCTTACACGGGTACAGCAATGGACCGTGAAGCAAGTGCAACAC
GCCTATATGATTTAACTATCACTAAACTTCAAGATCGTTCGTCTCCTGATCTATTCAAGGAAGCAACAATCGGTAAAGGT
AAACCTGCAGTATTCCACATCACTAAGCAGGGTGAAAAAGTTGAAGAAATCATGAAAATCGAACTGACTGATGCGATGAT
TTCTAACTACTCAGTATCGATTCAAGATGATCGCCCAGTAGAAACTATCACAATTTCATACACTGAAATGATGATGACAG
TGACACCTACTGATGACAAAAACAACACTTCTGCTCCGTTGGTTTACGGTTACAGCGGTGTTAAAGGTCAACAAATGTAA					