SecReT6, T6SS database

Detailed information of component protein

Summary

Component ID	T6CP003072
Component protein type	TssH
T6SS ID (Type)	T6SS00302 (Type i1)
Strain	Salmonella enterica subsp. enterica serovar Dublin str. CT_02021853
Replicon	chromosome
Sequence	Protein sequence (912 a.a.); Nucleotide sequence (2736 bp)
Reference	[1] Blondel CJ, Jiménez JC, Contreras I, et al. Comparative genomic analysis uncovers 3 novel loci encoding type six secretion systems differentially distributed in Salmonella serotypes. BMC Genomics. 2009 Aug 4;10:354. doi: 10.1186/1471-2164-10-354. PMID: 19653904 [2] Pezoa D, Blondel CJ, Silva CA, et al. Only one of the two type VI secretion systems encoded in the Salmonella enterica serotype Dublin genome is involved in colonization of the avian and murine hosts. Vet Res. 2014 Jan 9;45:2. doi: 10.1186/1297-9716-45-2. PMID: 24405577

Bioinformatics investigation has been performed on this T6SS

External database links

Locus tag (Gene)	SED_RS06265
Coordinate (Strand)	1213728..1216463 (-)
NCBI ID	446536953
RefSeq	NC_011205
Uniprot ID	-
KEGG ID	-
PDB ID	-

Pfam domain hit(s)

Domain	Pfam ID	E-value	Aligned region
AAA_2	PF07724.16	2.7e-37	630..791
AAA_lid_9	PF17871.3	1.4e-27	363..453
ClpB_D2-small	PF10431.11	5.7e-09	797..874
AAA	PF00004.31	3.8e-07	223..334

Transmembrane helices

Transmembrane helices are predicted using TMHMM 2.0 software.

Prediction	Region	Sequence
Outside	1-911	MIQIDLATLVKRLAPFAKQALEAAASECMSQQAAEITVAHVLLQMLATPRSDFRVIAERAEIGADDLRQALTVENYATARSSDSYPSFSPMLVEWLKEAWLLASAEMQQTELRGGVLLLALLHSPLRYLPPAAARLLTAINRDLLRQDFAGWTKESAESVILNADGQTASAIADTGDTLLARYAKNMTDDARQGRLDPVLCRDNEIDLMIDILCRRRKNNPVVVGEAGVGKSALIEGLALRIIAGQVPDKLRDTDIMTLDLGALQAGASVKGEFEKRFKGLMAEVIQSPKPVILFIDEAHTLIGAGNQQGGLDISNLLKPALARGELKTIAATTWSEYKKYFEKDSALSRRFQLVKVSEPNAAEATIILRGLSAVYEQSHGVLIDDEALQAAATLSERYLSGRQLPDKAIDVLDTACARVAINLSSPPRQISALTTLRQQCEAEIRQLEREIRIGLRSDTSRLNEVLAQYDETLSELDALEAAWRQQQTLVQEIIALRKGLLDETDATGNDETATPETEAVGSDDESVTAPPEAEPEISPAARLAQLTAELDALHHTQLLVSPHVDKKQIASVITEWTGVPLNRLSQNEMSVITDLPQWLGDTIKGQALAIKHLHKHLLTARADLRRPGRPLGAFLLAGPSGVGKTETVLQLAELLYGGRQYLTTINMSEFQEKHTVSRLIGSPPGYVGYGEGGVLTEAIRQKPYSVVLLDEVEKAHPDVLNLFYQAFDKGEMADGEGRLIDCKNVVFFLTSNLGYQVIVEHADNPEAMQEALYPVLADFFKPALLARMEVVPYLPLSRETLAVIIAGKLARLDNVLRARFGAEVVIEPEVTDEIMQRVTRAENGARMLESVIDGEMLPPLSLLLLQKMAANIAIARITLGVANGAFTADVEDVPDEDTQPVAEAEDEAVL

Signal peptides

Signal peptides and corresponding cleavage sites are predicted using SignalP 5.0 software.

Sec/SPI: "standard" secretory signal peptides transported by the Sec translocon and cleaved by Signal Peptidase I (Lep).

Sec/SPII: lipoprotein signal peptides transported by the Sec translocon and cleaved by Signal Peptidase II (Lsp).

Tat/SPI: Tat signal peptides transported by the Tat translocon and cleaved by Signal Peptidase I (Lep).

Prediction	Probability	Cleavage site	Signal peptide sequence
Other	0.9804	-	-

Protein sequence: 912 a.a.

						>T6CP003072 NC_011205:c1216463-1213728 [Salmonella enterica subsp. enterica serovar Dublin str. CT_02021853] [TssH]
MIQIDLATLVKRLAPFAKQALEAAASECMSQQAAEITVAHVLLQMLATPRSDFRVIAERAEIGADDLRQALTVENYATAR
SSDSYPSFSPMLVEWLKEAWLLASAEMQQTELRGGVLLLALLHSPLRYLPPAAARLLTAINRDLLRQDFAGWTKESAESV
ILNADGQTASAIADTGDTLLARYAKNMTDDARQGRLDPVLCRDNEIDLMIDILCRRRKNNPVVVGEAGVGKSALIEGLAL
RIIAGQVPDKLRDTDIMTLDLGALQAGASVKGEFEKRFKGLMAEVIQSPKPVILFIDEAHTLIGAGNQQGGLDISNLLKP
ALARGELKTIAATTWSEYKKYFEKDSALSRRFQLVKVSEPNAAEATIILRGLSAVYEQSHGVLIDDEALQAAATLSERYL
SGRQLPDKAIDVLDTACARVAINLSSPPRQISALTTLRQQCEAEIRQLEREIRIGLRSDTSRLNEVLAQYDETLSELDAL
EAAWRQQQTLVQEIIALRKGLLDETDATGNDETATPETEAVGSDDESVTAPPEAEPEISPAARLAQLTAELDALHHTQLL
VSPHVDKKQIASVITEWTGVPLNRLSQNEMSVITDLPQWLGDTIKGQALAIKHLHKHLLTARADLRRPGRPLGAFLLAGP
SGVGKTETVLQLAELLYGGRQYLTTINMSEFQEKHTVSRLIGSPPGYVGYGEGGVLTEAIRQKPYSVVLLDEVEKAHPDV
LNLFYQAFDKGEMADGEGRLIDCKNVVFFLTSNLGYQVIVEHADNPEAMQEALYPVLADFFKPALLARMEVVPYLPLSRE
TLAVIIAGKLARLDNVLRARFGAEVVIEPEVTDEIMQRVTRAENGARMLESVIDGEMLPPLSLLLLQKMAANIAIARITL
GVANGAFTADVEDVPDEDTQPVAEAEDEAVL*					

Nucleotide sequence: 2736 bp

						>T6CP003072 NC_011205:c1216463-1213728 [Salmonella enterica subsp. enterica serovar Dublin str. CT_02021853] [TssH]
ATGATCCAGATTGACTTAGCCACCCTGGTAAAACGGCTTGCTCCCTTCGCGAAACAGGCGCTGGAAGCGGCGGCGTCGGA
GTGTATGAGCCAGCAGGCGGCAGAAATTACCGTCGCGCATGTGCTGCTACAGATGCTGGCGACCCCGCGCAGCGACTTTC
GGGTGATTGCCGAACGTGCGGAGATCGGCGCCGATGATTTACGCCAGGCGCTGACGGTGGAAAATTACGCCACCGCCCGT
TCATCCGACAGCTACCCGTCGTTTTCCCCGATGCTGGTTGAATGGCTGAAAGAGGCCTGGCTGCTGGCCTCCGCGGAAAT
GCAGCAGACCGAACTGCGCGGCGGCGTGCTGCTGCTCGCCCTGCTGCATTCGCCGTTGCGCTACCTGCCGCCCGCCGCCG
CCCGGTTGCTGACCGCCATCAACCGCGACCTGCTCCGGCAGGATTTTGCCGGGTGGACGAAGGAGTCCGCCGAATCGGTG
ATCCTGAATGCGGACGGACAGACCGCCAGCGCCATAGCCGATACCGGCGACACCCTGCTGGCCCGCTATGCCAAAAACAT
GACCGACGATGCCCGGCAGGGGCGGCTTGATCCGGTGCTGTGCCGCGATAACGAAATTGACCTGATGATCGATATCCTCT
GCCGCCGCCGTAAAAATAATCCGGTGGTGGTGGGCGAAGCGGGCGTGGGCAAAAGCGCGCTGATTGAAGGGCTGGCGCTG
CGCATTATTGCCGGTCAGGTGCCGGACAAACTGCGCGATACCGATATTATGACGCTGGATCTCGGCGCATTACAGGCGGG
CGCGTCGGTGAAAGGTGAATTTGAGAAGCGCTTTAAGGGGCTGATGGCGGAAGTCATTCAGTCGCCGAAACCCGTCATCC
TGTTTATCGACGAAGCCCACACGCTGATTGGCGCGGGCAACCAGCAGGGCGGGCTGGATATCTCCAACCTGCTCAAACCG
GCACTGGCGCGCGGCGAGCTGAAAACCATCGCCGCCACCACCTGGAGCGAATACAAAAAATACTTCGAGAAAGACTCCGC
CCTGTCGCGCCGTTTCCAGTTAGTGAAAGTCAGCGAACCCAATGCTGCCGAAGCCACCATTATTCTGCGCGGCCTGTCGG
CGGTGTATGAGCAGTCCCACGGCGTGCTGATTGACGATGAAGCCTTACAGGCCGCTGCGACGTTGAGCGAGCGCTACCTG
TCAGGCCGCCAGTTGCCGGATAAGGCCATTGATGTGCTGGATACCGCCTGCGCCCGCGTGGCGATTAACCTCTCCTCGCC
GCCGAGACAAATCTCGGCGCTGACCACCCTGCGCCAGCAGTGTGAAGCGGAAATCCGCCAGCTTGAGCGTGAGATCCGTA
TTGGCCTGCGGTCGGACACCTCACGGCTAAACGAGGTTCTGGCGCAGTATGACGAAACGCTGAGCGAACTGGATGCGCTG
GAGGCCGCGTGGCGCCAGCAGCAGACGCTGGTGCAGGAGATTATCGCGCTGCGTAAGGGGCTGCTGGACGAAACGGACGC
TACCGGCAACGACGAAACCGCAACGCCTGAAACAGAGGCGGTGGGCAGTGACGATGAATCCGTCACAGCGCCGCCGGAAG
CGGAACCGGAAATTTCGCCAGCCGCCCGCCTCGCGCAGCTCACCGCCGAACTGGACGCCCTGCACCACACGCAGCTGCTG
GTCTCCCCACACGTCGATAAAAAACAGATAGCCAGCGTGATTACCGAATGGACCGGCGTGCCGCTTAACCGCCTGTCACA
AAACGAAATGTCGGTCATCACCGACCTGCCGCAGTGGCTGGGCGACACCATTAAAGGCCAGGCGCTGGCGATTAAGCACC
TGCACAAACACCTGCTGACCGCCCGCGCCGATCTGCGCCGTCCGGGACGCCCGCTCGGCGCGTTCCTGCTGGCCGGTCCC
AGCGGTGTCGGCAAAACCGAAACCGTGCTGCAACTGGCCGAACTGCTCTACGGCGGTCGCCAGTACCTGACCACCATCAA
TATGTCGGAGTTTCAGGAGAAACACACCGTTTCACGCCTGATTGGTTCGCCGCCGGGCTATGTCGGCTACGGCGAGGGCG
GCGTGCTGACCGAAGCGATTCGTCAGAAACCGTACTCCGTGGTGCTGCTCGACGAGGTGGAGAAAGCCCACCCGGACGTG
CTCAACCTGTTCTACCAGGCGTTCGACAAGGGCGAGATGGCCGATGGCGAAGGGCGTCTTATCGACTGTAAAAATGTGGT
GTTCTTCCTCACCTCCAACCTCGGCTATCAGGTGATTGTCGAACATGCCGACAACCCGGAAGCCATGCAGGAAGCGCTGT
ACCCGGTACTGGCGGACTTCTTTAAACCGGCGCTGCTGGCGCGTATGGAAGTGGTGCCGTACCTGCCGTTATCCAGAGAA
ACGCTTGCCGTCATTATCGCCGGGAAGCTGGCGCGGCTGGACAACGTACTGCGCGCCCGCTTCGGCGCGGAGGTGGTGAT
TGAGCCGGAGGTGACCGACGAAATCATGCAGCGCGTCACCCGCGCCGAAAACGGCGCGCGGATGCTGGAGTCGGTCATCG
ACGGCGAGATGCTGCCGCCGCTCTCCCTGCTGCTGTTGCAGAAAATGGCGGCGAATATCGCCATTGCCCGTATCACGCTG
GGCGTGGCAAACGGCGCGTTTACCGCGGATGTGGAGGATGTGCCGGATGAGGATACTCAGCCCGTAGCGGAAGCAGAGGA
CGAAGCCGTTCTATGA					