Detailed information NTG0997322

Bioinformatically predicted

Overview

• Name: comEA/celA/cilE
• Type: Machinery gene
• Locus tag: ABC811_RS05570
• Genome accession: NZ_CP155535
• Coordinates: 1083077..1083727 (-)
• Length: 216 a.a.
• NCBI ID: WP_000387352.1
• Uniprot ID: A0A4J1SCX2
• Organism: Streptococcus pneumoniae strain PJ755/1
• Function: dsDNA binding to the cell surface (predicted from homology) DNA binding and uptake

Genomic Context

Location: 1078077..1088727

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ABC811_RS05550 (ABC811_05545)	-	1078687..1079862 (-)	1176	WP_000655940.1	hypothetical protein	-
ABC811_RS05555 (ABC811_05550)	-	1079866..1080453 (-)	588	WP_000933542.1	ABC transporter ATP-binding protein	-
ABC811_RS05560 (ABC811_05555)	-	1080485..1080673 (-)	189	WP_010976492.1	hypothetical protein	-
ABC811_RS05565 (ABC811_05560)	comEC/celB	1080853..1083093 (-)	2241	WP_000942422.1	DNA internalization-related competence protein ComEC/Rec2	Machinery gene
ABC811_RS05570 (ABC811_05565)	comEA/celA/cilE	1083077..1083727 (-)	651	WP_000387352.1	helix-hairpin-helix domain-containing protein	Machinery gene
ABC811_RS05575 (ABC811_05570)	-	1083795..1084364 (-)	570	WP_000443745.1	GNAT family N-acetyltransferase	-
ABC811_RS05580 (ABC811_05575)	ald	1084541..1085652 (+)	1112	Protein_1103	alanine dehydrogenase	-
ABC811_RS05585 (ABC811_05580)	-	1085953..1086279 (-)	327	Protein_1104	TfoX/Sxy family protein	-
ABC811_RS05590 (ABC811_05585)	-	1086282..1086782 (-)	501	WP_000566988.1	GNAT family N-acetyltransferase	-
ABC811_RS05595 (ABC811_05590)	-	1086962..1087930 (-)	969	WP_000658181.1	PhoH family protein	-
ABC811_RS05600 (ABC811_05595)	-	1088016..1088231 (-)	216	WP_001232078.1	YozE family protein	-

Sequence

Protein

• Length: 216 a.a.
• Molecular weight: 23085.30 Da
• Isoelectric Point: 6.0661

>NTDB_id=997322 ABC811_RS05570 WP_000387352.1 1083077..1083727(-) (comEA/celA/cilE) [Streptococcus pneumoniae strain PJ755/1]
MEAIIEKIKEYKIIVICTGLGLLVGGFFLLKPAPQTSVKETNLQAEVAAVSKDSSTGKEVNKEEKEEPVEQDLITVDVKG
AVKSPGIYDLPVGSRVNDAVQKAGGLTEQADSKSLNLAQKVSDEALVYVPTKGEEAVSQQTGSGTASSTSKEKKVNLNKA
SLEELKQVKGLGGKRAQDIIDHREANGKFKSVDELKKVSGIGAKTIEKLKDYVTVD

Nucleotide

• Length: 651 bp

>NTDB_id=997322 ABC811_RS05570 WP_000387352.1 1083077..1083727(-) (comEA/celA/cilE) [Streptococcus pneumoniae strain PJ755/1]
ATGGAAGCAATTATCGAGAAAATCAAAGAGTATAAAATCATCGTCATCTGTACTGGTCTGGGCTTGCTTGTAGGAGGATT
TTTCCTGCTAAAGCCAGCTCCACAAACATCTGTCAAAGAGACGAATTTGCAGGCTGAAGTTGCAGCTGTTTCCAAGGACT
CATCGACCGGAAAGGAAGTGAACAAGGAAGAGAAGGAAGAACCAGTTGAACAAGATCTAATCACAGTAGATGTCAAAGGT
GCTGTCAAATCGCCAGGGATTTATGACTTGCCTGTAGGTAGTCGAGTCAATGATGCTGTTCAGAAGGCTGGTGGCTTGAC
AGAGCAAGCAGACAGCAAGTCGCTCAATCTAGCTCAGAAAGTTAGTGATGAGGCTCTGGTTTACGTTCCTACTAAGGGAG
AAGAAGCAGTTAGTCAACAGACTGGTTCGGGGACAGCTTCTTCAACAAGCAAGGAAAAGAAGGTCAATCTCAACAAGGCC
AGTCTGGAAGAACTCAAGCAGGTCAAGGGACTGGGAGGAAAACGAGCTCAGGACATTATTGACCATCGTGAGGCAAATGG
CAAGTTCAAGTCAGTAGACGAGCTCAAGAAGGTCTCTGGCATTGGTGCCAAGACCATAGAAAAACTTAAAGACTATGTTA
CAGTGGATTAA

Domains

Predicted by InterproScan.

• Helix-hairpin-helix motif (HHH_3) (151-214)

• SLBB domain (SLBB) (76-126)

3D structure

• AlphaFold DB: A0A4J1SCX2

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comEA/celA/cilE	Streptococcus pneumoniae TIGR4	97.685	100	0.977
comEA/celA/cilE	Streptococcus pneumoniae Rx1	95.833	100	0.958
comEA/celA/cilE	Streptococcus pneumoniae D39	95.833	100	0.958
comEA/celA/cilE	Streptococcus pneumoniae R6	95.833	100	0.958
comEA/celA/cilE	Streptococcus mitis NCTC 12261	95.37	100	0.954
comEA/celA/cilE	Streptococcus mitis SK321	92.593	100	0.926
comEA	Lactococcus lactis subsp. cremoris KW2	44.053	100	0.463
comEA	Latilactobacillus sakei subsp. sakei 23K	34.335	100	0.37